Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Guy A. McClellan"'
Autor:
Tran Khanh Tuan, Qiyue Hu, Zhang Junhu, Scott L. Butler, Atsuo Kuki, Qinghai Peng, Erik Jon Flahive, Graham L. Smith, Huichun Zhu, Deepak Dalvie, Plewe Michael Bruno, Jim Solowiej, Dorothy Delisle, Ted William Johnson, Wen Liu, Steven P. Tanis, Klaus Ruprecht Dress, Jon E. Kuehler, Guy A. McClellan, Xiaoming Yu, Hai Wang, Paul F. Richardson
Publikováno v:
Journal of Medicinal Chemistry. 54:3393-3417
HIV-1 integrase (IN) is one of three enzymes encoded by the HIV genome and is essential for viral replication, and HIV-1 IN inhibitors have emerged as a new promising class of therapeutics. Recently, we reported the synthesis of orally bioavailable a
Autor:
Karen A. Maegley, Pei-Pei Kung, Jeff Wang, Paul G. Richardson, Piet-Jan Sinnema, Fen Wang, Robert Steven Kania, Ketan S. Gajiwala, Simon Bergqvist, Pramod P. Mehta, Buwen Huang, Michael J. Hickey, Guy A. McClellan
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(12)
A series of novel and potent small molecule Hsp90 inhibitors was optimized using X-ray crystal structures. These compounds bind in a deep pocket of the Hsp90 enzyme that is partially comprised by residues Asn51 and Ser52. Displacement of several wate
Autor:
Quyen-Quyen T. Do, David M. Wilhite, Jack H. Kellum, Guy A. McClellan, Paul S. Humphries, Simon Bailey
Publikováno v:
ChemInform. 37
A series of pyridine ether PPAR agonists were synthesized through intermolecular palladium-catalyzed coupling of 2-halopyridines and alcohols. This method proved to be versatile, efficient, and amenable to parallel synthesis.
Autor:
Mary Hess, Simon Bailey, Christie Lance Christopher, Jack H. Kellum, Brett H. Simmons, Guy A. McClellan, Paul S. Humphries, Kathleen M. Ogilvie, Jonathon V. Almaden, Skalitzky Donald James, Young Ha Kim, Shaoxian Sun, Thomas J. Carlson, David M. Wilhite, James D. Fraser, Zehnder Luke Raymond, Sandra J. Barnum, Quyen-Quyen T. Do
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(23)
A series of novel pyridine-3-propanoic acids was synthesized. A structure–activity relationship study of these compounds led to the identification of potent dual PPARα/γ agonists with varied isoform selectivity. Based on the results of efficacy s