Zobrazeno 1 - 10
of 318
pro vyhledávání: '"Guy A Zimmerman"'
Autor:
Isaclaudia G de Azevedo-Quintanilha, Adriana Vieira-de-Abreu, André C Ferreira, Patricia A Reis, Tathiany I Silva, Danielle de O Nascimento, Robert A Campbell, Vanessa Estato, Andrew S Weyrich, Patrícia T Bozza, Guy A Zimmerman, Hugo C Castro-Faria-Neto
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0224610 (2019)
Malaria is an infectious disease of major worldwide clinical importance that causes a variety of severe, or complicated, syndromes including cerebral malaria, which is often fatal. Leukocyte integrins are essential for host defense but also mediate p
Externí odkaz:
https://doaj.org/article/1be4908b27c04be19b8252376dd78b83
Autor:
Monique Ramos de Oliveira Trugilho, Eugenio Damaceno Hottz, Giselle Villa Flor Brunoro, André Teixeira-Ferreira, Paulo Costa Carvalho, Gustavo Adolfo Salazar, Guy A Zimmerman, Fernando A Bozza, Patrícia T Bozza, Jonas Perales
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006385 (2017)
Dengue is the most prevalent human arbovirus disease worldwide. Dengue virus (DENV) infection causes syndromes varying from self-limiting febrile illness to severe dengue. Although dengue pathophysiology is not completely understood, it is widely acc
Externí odkaz:
https://doaj.org/article/274bd2ba3bd9421890ce5ab6f6d0406a
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 100, Pp 83-91 (2005)
Platelet-activating factor (PAF) is one of the most potent lipid mediators involved in inflammatory events. The acetyl group at the sn-2 position of its glycerol backbone is essential for its biological activity. Deacetylation induces the formation o
Externí odkaz:
https://doaj.org/article/a5a608b51ed54e2ab2c59b5e5dc89755
Autor:
Yasunari Miyazaki, Adriana Vieira-de-Abreu, Estelle S Harris, Amrapali M Shah, Andrew S Weyrich, Hugo C Castro-Faria-Neto, Guy A Zimmerman
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112770 (2014)
Integrin α(D)β(2) is the most recently identified member of the leukocyte, or β(2), subfamily of integrin heterodimers. Its distribution and functions on human leukocytes have not been clearly defined and are controversial. We examined these issue
Externí odkaz:
https://doaj.org/article/84d428e30b4c47ff82f830513c41eea8
Autor:
Mariana G A Teixeira-da-Cunha, Rachel N Gomes, Nathassia Roehrs, Fernando A Bozza, Stephen M Prescott, Diana Stafforini, Guy A Zimmerman, Patricia T Bozza, Hugo C Castro-Faria-Neto
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74567 (2013)
Current evidence indicates that dysregulation of the host inflammatory response to infectious agents is central to the mortality of patients with sepsis. Strategies to block inflammatory mediators such as PAF have been investigated as adjuvant therap
Externí odkaz:
https://doaj.org/article/b8cf7ee3c90241fa98b772576b2811a1
Autor:
Patricia A Reis, Vanessa Estato, Tathiany I da Silva, Joana C d'Avila, Luciana D Siqueira, Edson F Assis, Patricia T Bozza, Fernando A Bozza, Eduardo V Tibiriça, Guy A Zimmerman, Hugo C Castro-Faria-Neto
Publikováno v:
PLoS Pathogens, Vol 8, Iss 12, p e1003099 (2012)
Cerebral malaria (CM) is the most severe manifestation of Plasmodium falciparum infection in children and non-immune adults. Previous work has documented a persistent cognitive impairment in children who survive an episode of CM that is mimicked in a
Externí odkaz:
https://doaj.org/article/a08136b18d4445fc97b8cedcf70c6eb6
Autor:
Bjoern F Kraemer, Robert A Campbell, Hansjörg Schwertz, Mark J Cody, Zechariah Franks, Neal D Tolley, Walter H A Kahr, Stephan Lindemann, Peter Seizer, Christian C Yost, Guy A Zimmerman, Andrew S Weyrich
Publikováno v:
PLoS Pathogens, Vol 7, Iss 11, p e1002355 (2011)
Human β-defensins (hBD) are antimicrobial peptides that curb microbial activity. Although hBD's are primarily expressed by epithelial cells, we show that human platelets express hBD-1 that has both predicted and novel antibacterial activities. We ob
Externí odkaz:
https://doaj.org/article/12fe7201040e4bd9b94ebcb008245bc5
Autor:
Patricia A Reis, Clarissa M Comim, Fernanda Hermani, Bruno Silva, Tatiana Barichello, Aline C Portella, Flavia C A Gomes, Ive M Sab, Valber S Frutuoso, Marcus F Oliveira, Patricia T Bozza, Fernando A Bozza, Felipe Dal-Pizzol, Guy A Zimmerman, João Quevedo, Hugo C Castro-Faria-Neto
Publikováno v:
PLoS Pathogens, Vol 6, Iss 6, p e1000963 (2010)
Neurological impairments are frequently detected in children surviving cerebral malaria (CM), the most severe neurological complication of infection with Plasmodium falciparum. The pathophysiology and therapy of long lasting cognitive deficits in mal
Externí odkaz:
https://doaj.org/article/6f04660384fe4460800a2e88e7decbcc
Publikováno v:
Critical Care Clinics. 37:777-793
Reports examining lung histopathology in coronavirus disease 2019 (COVID-19) infection provide an essential body of information for clinicians and investigators. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-induced lung injury is comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0edf99e7703a300d17662e61eec58b20
https://doi.org/10.1016/j.ccc.2021.05.004
https://doi.org/10.1016/j.ccc.2021.05.004
Autor:
Marcus V. G. Lacerda, Eugenio D. Hottz, Bhanu Kanth Manne, Andrew S. Weyrich, Hugo Castro Faria Neto, Guy A. Zimmerman, Krystin Krauel, Emilie Montenont, Antoinette Blair, Neal D. Tolley, Isabel M. Medeiros-de-Moraes, Jesse W. Rowley, Matthew T. Rondina, Aaron C. Petrey, Elizabeth A. Middleton, Robert A. Campbell, Alicia S Eustes, Yasuhiro Kosaka, Li Guo
Publikováno v:
J Thromb Haemost
Background Heparanase (HPSE) is the only known mammalian enzyme that can degrade heparan sulfate. Heparan sulfate proteoglycans are essential components of the glycocalyx, and maintain physiological barriers between the blood and endothelial cells. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e53ee284a575380aa2c8d3ce3e6005
https://doi.org/10.1111/jth.15266
https://doi.org/10.1111/jth.15266