Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Guy A, Higgins"'
Autor:
Guy A. Higgins, Nicole K. Carroll, Matt Brown, Cam MacMillan, Leo B. Silenieks, Sandy Thevarkunnel, Julia Izhakova, Lilia Magomedova, Ines DeLannoy, Edward M. Sellers
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Long term benefits following short-term administration of high psychedelic doses of serotonergic and dissociative hallucinogens, typified by psilocybin and ketamine respectively, support their potential as treatments for psychiatric conditions such a
Externí odkaz:
https://doaj.org/article/60248d7199844455b8f88ef139c114c6
Autor:
Guy A. Higgins, Leo B. Silenieks, Cam MacMillan, Sandy Thevarkunnel, Anna I. Parachikova, Cedric Mombereau, Hanna Lindgren, Jesper F. Bastlund
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Amphetamine (AMP), methylphenidate (MPH), and atomoxetine (ATX) are approved treatments for ADHD, and together with nicotine (NIC), represent pharmacological agents widely studied on cognitive domains including attention and impulsive action in human
Externí odkaz:
https://doaj.org/article/40248544ad5a470bb8627859ed022969
Autor:
Guy A, Higgins, Leo B, Silenieks
Publikováno v:
Current topics in behavioral neurosciences. 57
Based on core symptoms of inattention and deficient impulse control, and the identification of effective pharmacotherapies such as amphetamine (AMP; Adderall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b8f3c9f19dd2811bbc408cf119288b82
https://pubmed.ncbi.nlm.nih.gov/35606638
https://pubmed.ncbi.nlm.nih.gov/35606638
Autor:
John A Rudd, Man P. Ngan, Zengbing Lu, Guy A. Higgins, Claudio Giuliano, Emanuela Lovati, Claudio Pietra
Publikováno v:
Frontiers in Pharmacology, Vol 7 (2016)
Background and Aims: Chemotherapy-induced acute and delayed emesis involves the activation of multiple pathways, with 5-hydroxytryptamine (5-HT; serotonin) playing a major role in the initial response. Substance P tachykinin NK1 receptor antagonists
Externí odkaz:
https://doaj.org/article/7fbbad8ac87848f89b3f836deb5ff427
Autor:
Nicole K Carroll, Annalise Van Niekerk, Colleen Taylor, Leo B. Silenieks, Guy A. Higgins, Neil Upton, Emily Van Niekerk
Publikováno v:
ACS Chemical Neuroscience. 10:3284-3295
The 5-HT releaser/reuptake inhibitor fenfluramine has been recently reported to provide benefit as an adjunctive treatment for Dravet and Lennox-Gastaut syndromes, two types of severe childhood epilepsy. Despite its enhancement of 5-HT function, many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cad6c72a491192e6b33436e2b296442
https://doi.org/10.1021/acschemneuro.8b00739
https://doi.org/10.1021/acschemneuro.8b00739
Autor:
Pat Brady, Naveena Madhyastha, Ravi Kanth Bhamidipati, Zainuddin Mohd, Dave Downie, Matthew J. Cato, Hong Lin, Céline Rouget, Tania Bakshi, Khuram W. Chaudhary, Dwight M. Morrow, Brian Donovan, Yasuji Matsuoka, Mark A. Seefeld, Kishore Pasikanti, Sridharan Rajagopal, Joerg Holenz, Wei Zhen, Robert W. Dougherty, Mark L. Chapman, Swapan Kumar Samanta, Tingting Fu, Philippe Lluel, Bharathi Mohan Kuppusamy, Guy A. Higgins
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3793-3797
Neuronal voltage-gated potassium channels, KV7s, are the molecular mediators of the M current and regulate membrane excitability in the central and peripheral neuronal systems. Herein, we report novel small molecule KV7 openers that demonstrate anti-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfef453d358d286fe6210e7d6cffeb3f
https://doi.org/10.1016/j.bmcl.2018.09.036
https://doi.org/10.1016/j.bmcl.2018.09.036
Autor:
Guy A, Higgins, Edward M, Sellers
Publikováno v:
Progress in brain research. 259
Nicotine use and dependence, typically achieved through cigarette smoking, but increasingly through vape products, is the leading cause of preventable death today. Despite a recognition that many current smokers would like to quit, the success rate a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f069ea9b3f67f3984e03b8267acc77ef
https://pubmed.ncbi.nlm.nih.gov/33541678
https://pubmed.ncbi.nlm.nih.gov/33541678
Autor:
Edward M. Sellers, Guy A. Higgins
Publikováno v:
Progress in Brain Research ISBN: 9780128245675
Nicotine use and dependence, typically achieved through cigarette smoking, but increasingly through vape products, is the leading cause of preventable death today. Despite a recognition that many current smokers would like to quit, the success rate a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::167d9ee626f7790b4fc956777c2399a8
https://doi.org/10.1016/bs.pbr.2021.01.007
https://doi.org/10.1016/bs.pbr.2021.01.007
Autor:
Lynn A. Hyde, Qi Zhang, Robert A. Del Vecchio, Prescott T. Leach, Mary E. Cohen-Williams, Lei Chen, Gwendolyn T. Wong, Nansie A. McHugh, Joseph Chen, Guy A. Higgins, Theodros Asberom, Wei Li, Dmitri Pissarnitski, Diane Levitan, Amin A. Nomeir, John W. Clader, Lili Zhang, Eric M. Parker
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2013 (2013)
Substantial evidence implicates -amyloid (A) peptides in the etiology of Alzheimer’s disease (AD). A is produced by the proteolytic cleavage of the amyloid precursor protein by - and -secretase suggesting that -secretase inhibition may provide ther
Externí odkaz:
https://doaj.org/article/992cb89d5ff04869837af4acc77fb5af
Publikováno v:
Behavioural Brain Research. 348:201-210
Previous studies demonstrated that NMDA receptor antagonists such as dizocilpine (MK801) and the GluN2B NMDA antagonist Ro 63–1908 promote impulsive action (motor impulsivity). The effects of these treatments on impulsive choice and decision-making
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8250bf57e3d13a0b566d91404d778872
https://doi.org/10.1016/j.bbr.2018.04.028
https://doi.org/10.1016/j.bbr.2018.04.028