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Akademický článek

Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell

Autor: Miklos Bagdany, Guido Veit, Ryosuke Fukuda, Radu G. Avramescu, Tsukasa Okiyoneda, Imad Baaklini, Jay Singh, Guy Sovak, Haijin Xu, Pirjo M. Apaja, Sara Sattin, Lenore K. Beitel, Ariel Roldan, Giorgio Colombo, William Balch, Jason C. Young, Gergely L. Lukacs

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)

The F508 deletion (F508del) in the cystic fibrosis transmembrane conductance regulator (CFTR) is the most common CF causing mutation. Here the authors show that cytosolic chaperones shift the F508del channel conformation to the native fold by kinetic

Externí odkaz: https://doaj.org/article/e14a35b0276c400f88eedbb10dd40d9d

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Anatomical and Radiological Description of the Macaca fascicularis Spine in Comparison with the Human Spine

Autor: Anant Krishnan, Guneet Kaleka, Scott Emerson, Guy Sovak, Heather Simmons, Kevin Brunner, Dane Schalk, John Sledge, Amber Hoggatt, Shanker Nesathurai

Publikováno v: Open Journal of Veterinary Medicine. 12:171-186

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fdf2e72e4ca0bfd65d2abe37dc908b2d
https://doi.org/10.4236/ojvm.2022.1212014

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The prevalence and characteristics of HIV/AIDS patients presenting at a chiropractic outpatient clinic in Toronto, Ontario. A retrospective, observational study

Autor: H Stephen, Injeyan, Gaelan, Connell, Katelyn, Foster, Deborah, Kopansky-Giles, Guy, Sovak, Tony, Tibbles

Publikováno v: The Journal of the Canadian Chiropractic Association. 62(2)

To determine the prevalence and presenting complaints of HIV/AIDS patients attending a chiropractic outpatient teaching clinic in downtown Toronto, and explore their self-reported comorbidities, medications used, and consumption of other complementar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9a0d1371a307aeae5fe9fdba24dd1bab
https://pubmed.ncbi.nlm.nih.gov/30305763

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TENS augments blood flow in somatotopically linked spinal cord segments and mitigates compressive ischemia

Autor: Guy Sovak, B S Budgell, D Soave

Publikováno v: Spinal Cord. 52:744-748

This was an acute basic physiological study in anesthetized adult male rats. The purpose of this study was to determine, in an animal model, whether innocuous somatic stimulation, in the form of transcutaneous electrical nerve stimulation (TENS), cou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ef4013a2ff18cb8b92964aaee34072
https://doi.org/10.1038/sc.2014.120

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TENS-like Stimulation Downregulates Inflammatory Cytokines in a PC-12 Cell Line

Autor: Guy Sovak, Brian Budgell

Publikováno v: Journal of manipulative and physiological therapeutics. 40(6)

Objectives The purpose of this study was to evaluate the effects of transcutaneous electrical nerve stimulation (TENS)–like stimulation on the expression of the proinflammatory cytokines tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::181dc37d8aec8d528c8367615252e111
https://pubmed.ncbi.nlm.nih.gov/28822472

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Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell

Autor: Jay Singh, Tsukasa Okiyoneda, Giorgio Colombo, Radu G. Avramescu, William E. Balch, Haijin Xu, Ryosuke Fukuda, Jason C. Young, Guido Veit, Guy Sovak, Ariel Roldan, Sara Sattin, Imad Baaklini, Pirjo M. Apaja, Lenore K. Beitel, Gergely L. Lukacs, Miklós Bagdány

Publikováno v: Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature communications 8 (2017). doi:10.1038/s41467-017-00444-4
info:cnr-pdr/source/autori:Bagdany M.; Veit G.; Fukuda R.; Avramescu R.G.; Okiyoneda T.; Baaklini I.; Singh J.; Sovak G.; Xu H.; Apaja P.M.; Sattin S.; Beitel L.K.; Roldan A.; Colombo G.; Balch W.; Young J.C.; Lukacs G.L./titolo:Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell/doi:10.1038%2Fs41467-017-00444-4/rivista:Nature communications/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume:8

Molecular chaperones are pivotal in folding and degradation of the cellular proteome but their impact on the conformational dynamics of near-native membrane proteins with disease relevance remains unknown. Here we report the effect of chaperone activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367b1592f93122124f7d7d06652c5cef
https://pubmed.ncbi.nlm.nih.gov/28855508

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Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

Autor: Marta Martinez-Vicente, David Westaway, Yasuo Uchiyama, Guy Sovak, Panaiyur S. Mohan, Devin M. Wolfe, Sooyeon Lee, Ralph A. Nixon, Ju-Hyun Lee, Ana Maria Cuervo, W. Haung Yu, Corrinne M. Peterhoff, Ashish C. Massey, Asok Kumar

Publikováno v: Cell. 141:1146-1158

SummaryMacroautophagy is a lysosomal degradative pathway essential for neuron survival. Here, we show that macroautophagy requires the Alzheimer's disease (AD)-related protein presenilin-1 (PS1). In PS1 null blastocysts, neurons from mice hypomorphic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e797cb6855affa0b13aaead60ffd74
https://doi.org/10.1016/j.cell.2010.05.008

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Osseointegration of Ti-6Al-4V alloy implants with a titanium nitride coating produced by a PIRAC nitriding technique: a long-term time course study in the rat

Autor: A. Weiss, Guy Sovak, Irena Gotman

Publikováno v: Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. 21(1)

This study examined bone tissue responses to Ti–6Al–4V alloy implants with a hard TiN coating applied by an original powder immersion reaction-assisted coating (PIRAC) nitriding method. Progression of implant fixation in the distal epiphysis and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3e9992f917ac51e9029311b5b0db55
https://pubmed.ncbi.nlm.nih.gov/25482093

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Osseointegration of Titanium Ti-6Al-4V Alloy Implants in the Rat Femur: A Time-course SEM Study

Autor: A. Weiss, Guy Sovak, Irena Gotman

Publikováno v: Microscopy and Microanalysis. 20:2110-2111

Biological fixation of uncemented endosseous implants requires the apposition of bone onto implant’s surface in a process named osseointegration [1]. The present study examined bone tissue response to Ti-6Al-4V alloy implanted into the rat femurs o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c904cfeb605b34ddf3fa398e952abc36
https://doi.org/10.1017/s1431927614012288

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