Zobrazeno 1 - 10
of 643
pro vyhledávání: '"Guy, Griebel"'
Autor:
Guy Griebel, Jeanne Stemmelin, Mati Lopez-Grancha, Valérie Fauchey, Franck Slowinski, Philippe Pichat, Gihad Dargazanli, Ahmed Abouabdellah, Caroline Cohen, Olivier E. Bergis
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-25 (2018)
Abstract Enhancing endogenous cannabinoid (eCB) signaling has been considered as a potential strategy for the treatment of stress-related conditions. Fatty acid amide hydrolase (FAAH) represents the primary degradation enzyme of the eCB anandamide (A
Externí odkaz:
https://doaj.org/article/080f7bdc1656430e82c1cafc30cdcfa0
Autor:
Philippe Pichat, Franck Slowinski, Olivier Bergis, Jeanne Stemmelin, Guy Griebel, Ahmed Abouabdellah, Gihad Dargazanli, Valérie Fauchey, Mati Lopez-Grancha, Caroline Cohen
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-25 (2018)
Scientific Reports
Scientific Reports
Enhancing endogenous cannabinoid (eCB) signaling has been considered as a potential strategy for the treatment of stress-related conditions. Fatty acid amide hydrolase (FAAH) represents the primary degradation enzyme of the eCB anandamide (AEA), oleo
Publikováno v:
Physiology & Behavior. 146:67-72
Memory dysfunctions are thought to play a crucial role both in the development and the maintenance of posttraumatic stress disorder (PTSD). Patients suffering from this condition persistently re-experience the traumatic event particularly when expose
Autor:
Guy Griebel, Sandra Beeské
Publikováno v:
In Vivo Models for Drug Discovery
Autor:
Guy, Griebel
Publikováno v:
British journal of pharmacology. 174(13)
Autor:
Mark D. Black, Denis Boulay, Rosy Sher, Guy Griebel, Sukhveen Sahni, Robert E. Featherstone, Franck Slowinski, Sathapana Kongsamut, Vanessa Naimoli, C. Desvignes, Kosley Raymond W, Geoffrey B. Varty, Xavier Vigé, Olivier Bergis, Lisa Potestio, Philippe Pichat, Henry Defex
Publikováno v:
Scientific Reports
Normalization of altered glutamate neurotransmission through activation of the mGluR2 has emerged as a new approach to treat schizophrenia. These studies describe a potent brain penetrant mGluR2 positive allosteric modulator (PAM), SAR218645. The com
Autor:
Denis Boulay, Lucianne Groenink, Berend Olivier, Tessa N. Douma, P. M. Verdouw, Millan Mark, Guy Griebel, Koen G.C. Westphal
Publikováno v:
Psychopharmacology. 231:1289-1303
As enhanced corticotropin-releasing factor (CRF) transmission is associated with induction of sensorimotor gating deficits, CRF1 receptor antagonists may reverse disrupted prepulse inhibition (PPI), an operational measure of sensorimotor gating. To d
Autor:
Raisa Nagorny, Pascal George, Zhongli Gao, Philippe Pichat, Hendrix James A, Siegfried Stengelin, Czechtizky Werngard, Lothar Schwink, Dominique Françon, Guy Griebel, Hurst William J
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6141-6145
Previous studies have shown that compound 1 displayed high affinity towards histamine H3 receptor (H3R), (human (h-H3R), K(i)=8.6 nM, rhesus monkey (rh-H3R), K(i)=1.2 nM, and rat (r-H3R), K(i)=16.5 nM), but exhibited high affinity for hERG channel. H
Autor:
R. Alonso, Patrick Avenet, Agnès Jacquet, Dominique Françon, Sandra Beeské, Guy Griebel, Christian Laufrais, Michel Decobert
Publikováno v:
Neuropharmacology. 70:19-26
5-Hydroxytryptamine (5-HT)2A antagonists are promising therapeutic agents for the treatment of sleep maintenance insomnias, but unlike hypnotics, they have limited effects on sleep initiation. This study evaluated the effects of several 5-HT₂A anta
Publikováno v:
Psychopharmacology. 228:97-107
The selective CRF1 (corticotropin releasing factor type 1) receptor antagonist SSR125543 has been previously shown to attenuate the long-term cognitive deficit produced by traumatic stress exposure. Memory disturbances described in post-traumatic str