Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Guy, Carter"'
Autor:
Robert F. Bruns, Qi Chen, Paloma Vidal, John Mehnert Schaus, Charles R. Yang, Stephen N. Mitchell, Steven Marc Massey, Nuria Diaz, Xushan Wang, David Andrew Coates, Rebecca A. Wright, Beverly A. Heinz, Kevin Matthew Gardinier, Greg Stephenson, James P. Beck, Rajni M. Bhardwaj, Julie F. Falcone, Bruce A. Dressman, Deanna L Maren, Anette M. Johansson, David Michael Remick, Jeff W. Cramer, Cohen Michael Philip, Brian Morgan Watson, Jeffery Richardson, Kjell Svensson, Xin Zhou, Erik James Hembre, Serge Louis Boulet, Reinhard Matthew Robert, Daniel S. Richards, Junliang Hao, David M. Bender, Guy Carter, Christopher David Beadle, Brian G. Getman, Wolfangel Craig Daniel, Diseroad Benjamin Alan, Jason K. Myers, Joseph H. Krushinski, David Edward Tupper
Publikováno v:
Journal of Medicinal Chemistry. 62:8711-8732
Clinical development of catechol-based orthosteric agonists of the dopamine D1 receptor has thus far been unsuccessful due to multiple challenges. To address these issues, we identified LY3154207 (...
Autor:
Wesley H. Anderson, Paul L. Ornstein, Vladamir Tolstikov, Guy Carter, Renhua Li, Brian J. Eastwood, Carl D Overshiner, Alexander Nikolayev, Kurt Rasmussen, Stephen Smith, Gary Gilmour, Stephen Swanson, Linda M. Rorick-Kehn, Xia Li, Keith A. Wafford, John T. Catlow, Jeffrey M. Witkin, Stephen N. Mitchell, Charles H. Mitch, Ming-Shang Kuo, Jennifer Li, James A. Monn
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 361:68-86
The ability of the N-methyl-d-aspartate receptor antagonist ketamine to alleviate symptoms in patients suffering from treatment-resistant depression (TRD) is well documented. In this paper, we directly compare in vivo biologic responses in rodents el
Autor:
Junliang, Hao, James P, Beck, John M, Schaus, Joseph H, Krushinski, Qi, Chen, Christopher D, Beadle, Paloma, Vidal, Matthew R, Reinhard, Bruce A, Dressman, Steven M, Massey, Serge L, Boulet, Michael P, Cohen, Brian M, Watson, David, Tupper, Kevin M, Gardinier, Jason, Myers, Anette M, Johansson, Jeffery, Richardson, Daniel S, Richards, Erik J, Hembre, David M, Remick, David A, Coates, Rajni M, Bhardwaj, Benjamin A, Diseroad, David, Bender, Greg, Stephenson, Craig D, Wolfangel, Nuria, Diaz, Brian G, Getman, Xu-Shan, Wang, Beverly A, Heinz, Jeff W, Cramer, Xin, Zhou, Deanna L, Maren, Julie F, Falcone, Rebecca A, Wright, Stephen N, Mitchell, Guy, Carter, Charles R, Yang, Robert F, Bruns, Kjell A, Svensson
Publikováno v:
Journal of medicinal chemistry. 62(19)
Clinical development of catechol-based orthosteric agonists of the dopamine D1 receptor has thus far been unsuccessful due to multiple challenges. To address these issues, we identified LY3154207 (
Autor:
James A. Monn, Kurt Rasmussen, Guy Carter, Stephen N. Mitchell, Linda M. Rorick-Kehn, Jeffrey M. Witkin, Bryan G. Johnson, Xia Li, Darryle D. Schoepp, Carl D Overshiner
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 358:71-82
Ketamine is a rapidly acting antidepressant in patients with treatment-resistant depression (TRD). Although the mechanisms underlying these effects are not fully established, inquiry to date has focused on the triggering of synaptogenesis transductio
Autor:
Arjan Blokland, Sarah Hescham, Stephen N. Mitchell, Ali Jahanshahi, Trevor Sharp, Yasin Temel, Guy Carter, Judith Schweimer
Publikováno v:
Brain Structure & Function, 221(8). Springer
Brain Structure & Function
Brain Structure & Function
Deep brain stimulation (DBS) of the fornix has gained interest as a potential therapy for advanced treatment-resistant dementia, yet the mechanism of action remains widely unknown. Previously, we have reported beneficial memory effects of fornix DBS
Publikováno v:
BSAVA Congress Proceedings 2018 ISBN: 9781910443583
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2ad89acf67ae446831d8d77c2482798
https://doi.org/10.22233/9781910443590.44.1
https://doi.org/10.22233/9781910443590.44.1
Autor:
Michelle M Menezes, Jeffrey M. Witkin, Kjell A. Svensson, Brian J. Eastwood, Eyassu Chernet, Michael J. O'Neill, Julie F. Falcone, Keith A. Wafford, Hong Wang, Linda K. Thompson, John W. Ryder, Stephen N. Mitchell, Junliang Hao, John Mehnert Schaus, Robert F. Bruns, Alex J. Harper, Meghane E. Masquelin, Deanna L Maren, Xia Li, Tracey K. Murray, Charles R. Yang, Elaine Shanks, Jason Katner, Linli Zhang, Guy Carter, James P. Beck, Patrick L. Love
Publikováno v:
Neuropharmacology. 128
DETQ, an allosteric potentiator of the dopamine D1 receptor, was tested in therapeutic models that were known to respond to D1 agonists. Because of a species difference in affinity for DETQ, all rodent experiments used transgenic mice expressing the
Autor:
Jon K. Reel, Akihiko Kato, Gary Gilmour, Keith A. Wafford, Warren J. Porter, Jennifer Li, Brian J. Eastwood, Stephen N. Mitchell, Guy Carter, Scott D. Gleason, Wesley Seidel, Kevin Matthew Gardinier, Jeffrey M. Witkin, Andrew McCarthy
Publikováno v:
Neuropharmacology. 126
6-[(1S)-1-[1-[5-(2-hydroxyethoxy)-2-pyridyl]pyrazol-3-yl]ethyl]-3H-1,3-benzothiazol-2-one (LY3130481 or CERC-611) is a selective antagonist of AMPA receptors containing transmembrane AMPA receptor regulatory protein (TARP) γ-8. This molecule has bee
Autor:
Chris Ireland, William Aalbersberg, Raymond Andersen, Semiramis Ayral-Kaloustian, Roberto Berlinck, Valerie Bernan, Guy Carter, Alice Churchill, Jon Clardy, Gisela Concepcion, E. De Silva, Carolyn Discafani, Tito Fojo, Philip Frost, Donna Gibson, Lee Greenberger, Michael Greenstein, Mary Kay Harper, Robert Mallon, Frank Loganzo, Maria Nunes, Marianne Poruchynsky, Arie Zask
Publikováno v:
Pharmaceutical Biology. 41:15-38
The National Cooperative Natural Products Drug Discovery Group (NCNPDDG) “Anticancer Agents from Unique Natural Products Sources, CA 67786” was first awarded in September 1995. The goal of the project is to discover and develop novel anticancer a