Výsledky vyhledávání - "Guvvala N. Reddy"

Synthesis of a Chiral Precursor for No-Carrier-Added (NCA) PET Tracer 6-[18F]Fluoro-L-dopa Based on Regio- and Enantioselective Alkylation of 2,4-Bis(chloromethyl)-5-iodoanisole

Autor: Chiaki Kuroda, Yoshiki Teramoto, Nobuko Muto, Noritoshi Nakane, Guvvala N. Reddy, Nami Niimura, Hiroyuki Nogami, Takashi Umeyama, Atsushi Ochi

Publikováno v: Bulletin of the Chemical Society of Japan. 73:417-422

(2S,5S)-5-(3-Formyl-6-iodo-4-methoxybenzyl)-1-t-butoxycarbonyl-2-t-butyl-3-methyl-4-imidazolidinone (11), a chiral intermediate towards NCA PET tracer 6-[18F]fluoro-L-dopa (1), was synthesized from 3-iodoanisole in four steps. 3-Iodoanisole was first

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec6b9ec3eb66aec7d508aec9256233fc
https://doi.org/10.1246/bcsj.73.417

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An improved synthesis of no-carrier-added (NCA) 6-[18F]Fluoro-l-DOPA and its remote routine production for PET investigations of dopaminergic systems

Autor: Marc Haeberli, Hans-Frieder Beer, Guvvala N. Reddy, August P. Schubiger

Publikováno v: Applied Radiation and Isotopes. 44:645-649

A detailed and improved synthetic procedure to produce NCA 6-[ 18 F]fluoro- l -dopa (6-FDOPA) is described. A remotely-operable system for its routine production was built and tested for stable and reproducible tracer production ( n > 20). Commercial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::853f2f07cd6ba21890128037704ce70b
https://doi.org/10.1016/0969-8043(93)90126-u

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ChemInform Abstract: Synthesis of a Chiral Precursor for No-Carrier-Added (NCA) PET Tracer 6-[18F]Fluoro-L-dopa Based on Regio- and Enantioselective Alkylation of 2,4-Bis(chloromethyl)-5-iodoanisole

Autor: Atsushi Ochi, Takashi Umeyama, Yoshiki Teramoto, Nami Niimura, Guvvala N. Reddy, Nobuko Muto, Chiaki Kuroda, Hiroyuki Nogami, Noritoshi Nakane

Publikováno v: ChemInform. 31

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f067f776de74fc40f014c7650a126614
https://doi.org/10.1002/chin.200019178

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Use of 2-dimethylaminopyridine in tritium and deuterium exchange reactions

Autor: Mark J. Kurth, Hank J. Segall, Christopher J. Soares, Guvvala N. Reddy

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 29:1257-1260

Advantages of 2-dimethylaminopyridine as base in isotope exchange reactions that occur via enol formation are described for the preparation of deuterium and tritium labeled hexanal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94c33bc575102ffc4872a950f468a3be
https://doi.org/10.1002/jlcr.2580291110

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Quality assurance and quality control methods for animal and human applications of no-carrier-added 6-[18F]fluorodopa for PET investigations of dopaminergic systems

Autor: Guvvala N. Reddy, August P. Schubiger, P. H. Hasler, Hans-Frieder Beer, Marc Haeberli

Publikováno v: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 44(7)

No-Carrier-Added (NCA) 6-[ 18 F]fluoro- l -dopa (6-FDOPA) is being produced routinely for PET investigations of dopaminergic systems at our Institute. We describe here in detail the quality assurance methods involved in its multi-step developmental s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4c7265f3e29ddf08e784bef4f759d0
https://pubmed.ncbi.nlm.nih.gov/8339075

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