Relationship between CD34/CD38 and side population (SP) defined leukemia stem cell compartments in acute myeloid leukemia

Autor: Zinia J. Kwidama, Arjo R. Rutten, Gert J.L. Kaspers, Jacqueline Cloos, Gert J. Ossenkoppele, Guus Westra, Bijan Moshaver, Sonja Zweegman, Angèle Kelder, Rolf Wouters, Gerrit Jan Schuurhuis

Publikováno v: Leukemia Research, 81, 27-34. Elsevier Limited
Moshaver, B, Wouters, R F, Kelder, A, Ossenkoppele, G J, Westra, G A H, Kwidama, Z, Rutten, A R, Kaspers, G J L, Zweegman, S, Cloos, J & Schuurhuis, G J 2019, ' Relationship between CD34/CD38 and side population (SP) defined leukemia stem cell compartments in acute myeloid leukemia ', Leukemia Research, vol. 81, pp. 27-34 . https://doi.org/10.1016/j.leukres.2019.04.004

Leukemic stem cells (LSCs), defined by CD34/CD38 expression, are believed to be essential for leukemia initiation and therapy resistance in acute myeloid leukemia. In addition, the side population (SP), characterized by high Hoechst 33342 efflux, ref

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c670abc779baaf92e630cbde304da081
https://research.vumc.nl/en/publications/ca980246-4a24-4904-b4aa-53285db29f62

Immunologic purging of autologous peripheral blood stem cell products based on CD34 and CD133 expression can be effectively and safely applied in half of the acute myeloid leukemia patients

Autor: N. Feller, Gerrit Jan Schuurhuis, Guus Westra, Geert Weijers, Marjolein A. van der Pol, Taco Waaijman, Gert J. Ossenkoppele

Publikováno v: Clinical Cancer Research, 11(13), 4793-4801. American Association for Cancer Research Inc.
Feller, N, van der Pol, M A, Waaijman, T, Weijers, G W D, Westra, G, Ossenkoppele, G J & Schuurhuis, G J 2005, ' Immunologic purging of autologous peripheral blood stem cell products based on CD34 and CD133 expression can be effectively and safely applied in half of the acute myeloid leukemia patients ', Clinical Cancer Research, vol. 11, no. 13, pp. 4793-4801 . https://doi.org/10.1158/1078-0432.CCR-05-0031

Purpose: Several studies have shown survival benefit by autologous stem cell transplantation in acute myeloid leukemia (AML) after purging of grafts. This has, however, not been confirmed in randomized studies due to high toxicity of purging modaliti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b4eeaa20a9e1dc9d90a43d74b3c8820
https://doi.org/10.1158/1078-0432.ccr-05-0031

Early Apoptosis Largely Accounts for Functional Impairment of CD34+Cells in Frozen-Thawed Stem Cell Grafts

Autor: Angelika M. Dräger, Peter C. Huijgens, Gerrit Jan Schuurhuis, Floortje L. Kessler, Elsken van der Wall, Fransien de Boer, Guus Westra, Herbert M. Pinedo, Tanja Netelenbos, Geert Weijers, M. Monnee-Van Muijen, J. W. Oberink

Publikováno v: Journal of hematotherapy & stem cell research, 11(6), 951. Mary Ann Liebert

Quality assessment of stem cell grafts is usually performed by flow cytometric CD34(+) enumeration or assessment of clonogenic output of fresh material. Previously, we identified the occurrence of early apoptosis, not detectable with the permeability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b66e3a402318f3ed361d5125166e238
https://doi.org/10.1089/152581602321080619

Defining consensus leukemia-associated immunophenotypes for detection of minimal residual disease in acute myeloid leukemia in a multicenter setting

Autor: Rik A. Brooimans, Nicole Feller, Jan-Willem Gratama, H Wind, I. de Greef, Gerrit-Jan Schuurhuis, V H J van der Velden, Patrik Aerts, Angèle Kelder, Nancy Boeckx, M. Leenders, J. G te Marvelde, Frank Preijers, Guus Westra

Publikováno v: Blood Cancer Journal, 3, pp. e129
Blood Cancer Journal
Feller, N, van der Velden, V H J, Brooimans, R A, Boeckx, N, Preijers, F, Kelder, A, de Greef, I, Westra, G, te Marvelde, J G, Aerts, P, Wind, H, Leenders, M, Gratama, J W & Schuurhuis, G J 2013, ' Defining consensus leukemia-associated immunophenotypes for detection of minimal residual disease in acute myeloid leukemia in a multicenter setting ', Blood cancer journal, vol. 3, e129 . https://doi.org/10.1038/bcj.2013.27
Blood Cancer Journal, 3, e129
Blood cancer journal, 3:e129. Nature Publishing Group
Blood Cancer Journal, 3. Nature Publishing Group

Contains fulltext : 186455.pdf (Publisher’s version ) (Open Access) Flow-cytometric detection of minimal residual disease (MRD) has proven in several single-institute studies to have an independent prognostic impact. We studied whether this relativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f88cada1faa950de5a787ab4c72389e
https://hdl.handle.net/2066/186455

Immunophenotypic patterns of childhood acute leukemias in Indonesia

Autor: Eddy, Supriyadi, Pudjo H, Widjajanto, Anjo J p, Veerman, Ignatius, Purwanto, Yetty M, Nency, Stefanus, Gunawan, Selvi, Nafianti, Dewajani, Purnomosari, Umi S, Intansari, Guus, Westra, Jacqueline, Cloos

Publikováno v: Asian Pacific journal of cancer prevention : APJCP. 12(12)

Immunophenotyping, as suggested by WHO, may improve diagnosis of childhood leukemia since it offers a better classification of the hematopoietic lineage of malignant cells as compared to morphology. Therefore, we aimed to determine the proportion of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::17b430adffc539665caf86aa3f1234f5
https://pubmed.ncbi.nlm.nih.gov/22471485