Výsledky vyhledávání

Relationship between CD34/CD38 and side population (SP) defined leukemia stem cell compartments in acute myeloid leukemia

Autor: Zinia J. Kwidama, Arjo R. Rutten, Gert J.L. Kaspers, Jacqueline Cloos, Gert J. Ossenkoppele, Guus Westra, Bijan Moshaver, Sonja Zweegman, Angèle Kelder, Rolf Wouters, Gerrit Jan Schuurhuis

Publikováno v: Leukemia Research, 81, 27-34. Elsevier Limited
Moshaver, B, Wouters, R F, Kelder, A, Ossenkoppele, G J, Westra, G A H, Kwidama, Z, Rutten, A R, Kaspers, G J L, Zweegman, S, Cloos, J & Schuurhuis, G J 2019, ' Relationship between CD34/CD38 and side population (SP) defined leukemia stem cell compartments in acute myeloid leukemia ', Leukemia Research, vol. 81, pp. 27-34 . https://doi.org/10.1016/j.leukres.2019.04.004

Leukemic stem cells (LSCs), defined by CD34/CD38 expression, are believed to be essential for leukemia initiation and therapy resistance in acute myeloid leukemia. In addition, the side population (SP), characterized by high Hoechst 33342 efflux, ref

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c670abc779baaf92e630cbde304da081
https://research.vumc.nl/en/publications/ca980246-4a24-4904-b4aa-53285db29f62

Zobrazit plný text záznamu

ZAP70 in B-CLL cells related to the expression in NK cells is a surrogate marker for mutational status

Autor: Andre P. Abbes, Theresia M. Westers, Arjan A. van de Loosdrecht, Annuska Strunk, Guus Westra, Martine E.D. Chamuleau, Pino J. Poddighe, Tom G. H. Wiggers, Ellen Kuiper-Kramer

Publikováno v: Cytometry Part B: Clinical Cytometry. 86:280-287

The strongest prognostic factor in chronic B-cell lymphocytic leukemia (CLL) is the mutational status of the immunoglobulin heavy chain variable region (IGHV) genes. Determination of this mutational status is laborious and therefore not applied in ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f337954d6925325c34cc8afb8942d13
https://doi.org/10.1002/cyto.b.21132

Zobrazit plný text záznamu

Interleukin-2 receptor alpha-chain (CD25) expression on leukaemic blasts is predictive for outcome and level of residual disease in AML

Autor: Anna van Rhenen, Nicole Feller, Gerrit Jan Schuurhuis, Sonja Zweegman, Gert J. Ossenkoppele, Monique Terwijn, Guus Westra, Angèle Kelder

Publikováno v: Terwijn, M, Feller, N, van Rhenen, A, Kelder, A, Westra, G A, Zweegman, S, Ossenkoppele, G J & Schuurhuis, G J 2009, ' Interleukin-2 receptor alpha-chain (CD25) expression on leukaemic blasts is predictive for outcome and level of residual disease in AML ', European Journal of Cancer, vol. 45, no. 9, pp. 1692-1699 . https://doi.org/10.1016/j.ejca.2009.02.021
European Journal of Cancer, 45(9), 1692-1699. Pergamon

We investigated the role of CD25 as a prognostic marker in acute myeloid leukaemia (AML). Seventy-two newly diagnosed patients ≤60 years were retrospectively analysed by flow cytometry for CD25 positivity of AML blasts. Patients with CD25 expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92aa13ed92e6e3c32e7c854f01d95928
https://doi.org/10.1016/j.ejca.2009.02.021

Zobrazit plný text záznamu

Immunologic purging of autologous peripheral blood stem cell products based on CD34 and CD133 expression can be effectively and safely applied in half of the acute myeloid leukemia patients

Autor: N. Feller, Gerrit Jan Schuurhuis, Guus Westra, Geert Weijers, Marjolein A. van der Pol, Taco Waaijman, Gert J. Ossenkoppele

Publikováno v: Clinical Cancer Research, 11(13), 4793-4801. American Association for Cancer Research Inc.
Feller, N, van der Pol, M A, Waaijman, T, Weijers, G W D, Westra, G, Ossenkoppele, G J & Schuurhuis, G J 2005, ' Immunologic purging of autologous peripheral blood stem cell products based on CD34 and CD133 expression can be effectively and safely applied in half of the acute myeloid leukemia patients ', Clinical Cancer Research, vol. 11, no. 13, pp. 4793-4801 . https://doi.org/10.1158/1078-0432.CCR-05-0031

Purpose: Several studies have shown survival benefit by autologous stem cell transplantation in acute myeloid leukemia (AML) after purging of grafts. This has, however, not been confirmed in randomized studies due to high toxicity of purging modaliti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b4eeaa20a9e1dc9d90a43d74b3c8820
https://doi.org/10.1158/1078-0432.ccr-05-0031

Zobrazit plný text záznamu

High percentage of CD34-positive cells in autologous AML peripheral blood stem cell products reflects inadequate in vivo purging and low chemotherapeutic toxicity in a subgroup of patients with poor clinical outcome

Autor: Peter C. Huijgens, M A van der Pol, Nicole Feller, A van Stijn, Gert J. Ossenkoppele, Gerrit-Jan Schuurhuis, G W D Weijers, Guus Westra

Publikováno v: Leukemia. 17:68-75

In this study, a high CD34% in autologous peripheral blood stem cell (PBSC) products from 71 AML patients was associated directly with a high relapse rate (P = 0.006) and inversely with disease-free survival (P = 0.003), irrespective whether patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b702ad298a6a0c4b704575e63f6e8676
https://doi.org/10.1038/sj.leu.2402781

Zobrazit plný text záznamu

Early Apoptosis Largely Accounts for Functional Impairment of CD34+Cells in Frozen-Thawed Stem Cell Grafts

Autor: Angelika M. Dräger, Peter C. Huijgens, Gerrit Jan Schuurhuis, Floortje L. Kessler, Elsken van der Wall, Fransien de Boer, Guus Westra, Herbert M. Pinedo, Tanja Netelenbos, Geert Weijers, M. Monnee-Van Muijen, J. W. Oberink

Publikováno v: Journal of hematotherapy & stem cell research, 11(6), 951. Mary Ann Liebert

Quality assessment of stem cell grafts is usually performed by flow cytometric CD34(+) enumeration or assessment of clonogenic output of fresh material. Previously, we identified the occurrence of early apoptosis, not detectable with the permeability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b66e3a402318f3ed361d5125166e238
https://doi.org/10.1089/152581602321080619

Zobrazit plný text záznamu

ZAP70 in B-CLL cells related to the expression in NK cells is a surrogate marker for mutational status

Autor: Tom G H, Wiggers, Guus, Westra, Theresia M, Westers, Andre P, Abbes, Annuska, Strunk, Ellen, Kuiper-Kramer, Pino, Poddighe, Arjan A, van de Loosdrecht, Martine E D, Chamuleau

Publikováno v: Cytometry. Part B, Clinical cytometry.

The strongest prognostic factor in chronic B-cell lymphocytic leukaemia (CLL) is the mutational status of the immunoglobulin heavy chain variable region (IGHV) genes. Determination of this mutational status is laborious and therefore not applied in r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6dc074d4687459a557303443d13ec290
https://pubmed.ncbi.nlm.nih.gov/24124110

Zobrazit plný text záznamu

Defining consensus leukemia-associated immunophenotypes for detection of minimal residual disease in acute myeloid leukemia in a multicenter setting

Autor: Rik A. Brooimans, Nicole Feller, Jan-Willem Gratama, H Wind, I. de Greef, Gerrit-Jan Schuurhuis, V H J van der Velden, Patrik Aerts, Angèle Kelder, Nancy Boeckx, M. Leenders, J. G te Marvelde, Frank Preijers, Guus Westra

Publikováno v: Blood Cancer Journal, 3, pp. e129
Blood Cancer Journal
Feller, N, van der Velden, V H J, Brooimans, R A, Boeckx, N, Preijers, F, Kelder, A, de Greef, I, Westra, G, te Marvelde, J G, Aerts, P, Wind, H, Leenders, M, Gratama, J W & Schuurhuis, G J 2013, ' Defining consensus leukemia-associated immunophenotypes for detection of minimal residual disease in acute myeloid leukemia in a multicenter setting ', Blood cancer journal, vol. 3, e129 . https://doi.org/10.1038/bcj.2013.27
Blood Cancer Journal, 3, e129
Blood cancer journal, 3:e129. Nature Publishing Group
Blood Cancer Journal, 3. Nature Publishing Group

Contains fulltext : 186455.pdf (Publisher’s version ) (Open Access) Flow-cytometric detection of minimal residual disease (MRD) has proven in several single-institute studies to have an independent prognostic impact. We studied whether this relativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f88cada1faa950de5a787ab4c72389e
https://hdl.handle.net/2066/186455

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání