Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Guttorm Haraldsen"'
Autor:
Torleif Tollefsrud Gjølberg, Jonas Aakre Wik, Hanna Johannessen, Stig Krüger, Nicola Bassi, Panagiotis F. Christopoulos, Malin Bern, Stian Foss, Goran Petrovski, Morten C. Moe, Guttorm Haraldsen, Johanna Hol Fosse, Bjørn Steen Skålhegg, Jan Terje Andersen, Eirik Sundlisæter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Antibody-based blocking of vascular endothelial growth factor (VEGF) reduces choroidal neovascularization (CNV) and retinal edema, rescuing vision in patients with neovascular age-related macular degeneration (nAMD). However, poor response a
Externí odkaz:
https://doaj.org/article/76fcbbf1b309412aacb2029fbbf2cf3a
Autor:
Mona Dixon Gundersen, Kenneth Bowitz Larsen, Kay Martin Johnsen, Rasmus Goll, Jon Florholmen, Guttorm Haraldsen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Epithelial alarmins are gaining interest as therapeutic targets for chronic inflammation. The nuclear alarmin interleukin-33 (IL-33) is upregulated in the colonic mucosa of acute ulcerative colitis (UC) and may represent an early instigator
Externí odkaz:
https://doaj.org/article/695bf0f5df8a40ea903dcf7b5e98a85a
Autor:
Jonas Aakre Wik, Danh Phung, Shrikant Kolan, Guttorm Haraldsen, Bjørn Steen Skålhegg, Johanna Hol Fosse
Publikováno v:
FEBS Open Bio, Vol 11, Iss 6, Pp 1719-1730 (2021)
Endothelial cell function and metabolism are closely linked to differential use of energy substrate sources and combustion. While endothelial cell migration is promoted by 2‐phosphofructokinase‐6/fructose‐2,6‐bisphosphatase (PFKFB3)‐driven
Externí odkaz:
https://doaj.org/article/0eff95fed2ab412194f21fea35b4a63a
Autor:
Olav Sundnes, William Ottestad, Camilla Schjalm, Peter Lundbäck, Lars la Cour Poulsen, Tom Eirik Mollnes, Guttorm Haraldsen, Torsten Eken
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-10 (2021)
Abstract Background Alarmins are considered proximal mediators of the immune response after tissue injury. Understanding their biology could pave the way for development of new therapeutic targets and biomarkers in human disease, including multiple t
Externí odkaz:
https://doaj.org/article/f12796fc20414a50b606752fc86cd814
Autor:
Francesca Gatti, Sobuj Mia, Clara Hammarström, Nadine Frerker, Bjarte Fosby, Junbai Wang, Wojciech Pietka, Olav Sundnes, Johanna Hol, Monika Kasprzycka, Guttorm Haraldsen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Interleukin (IL)-33 is a cytokine that appears to mediate fibrosis by signaling via its receptor ST2 (IL-33R/IL1RL1). It is also, however, a protein that after synthesis is sorted to the cell nucleus, where it appears to affect chromatin fol
Externí odkaz:
https://doaj.org/article/41b1343f8dc5458fba782e689f421616
Autor:
William Ottestad, Ingrid N. Rognes, Erlend Skaga, Cassandra Frisvoll, Guttorm Haraldsen, Torsten Eken, Peter Lundbäck
Publikováno v:
Molecular Medicine, Vol 26, Iss 1, Pp 1-8 (2019)
Abstract Background HMGB1 is a mediator of systemic inflammation in sepsis and trauma, and a promising biomarker in many diseases. There is currently no standard operating procedure for pre-analytical handling of HMGB1 samples, despite that pre-analy
Externí odkaz:
https://doaj.org/article/fe81579cecbe4541b1ba94d8c0aa117f
Autor:
Gaoyang Li, Shrikant Shantilal Kolan, Shuai Guo, Katarzyna Marciniak, Pratibha Kolan, Giulia Malachin, Franco Grimolizzi, Guttorm Haraldsen, Bjørn Steen Skålhegg
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Delayed-type hypersensitivity arthritis (DTHA) is a recently established experimental model of rheumatoid arthritis (RA) in mice with pharmacological values. Despite an indispensable role of CD4+ T cells in inducing DTHA, a potential role for CD4+ T
Externí odkaz:
https://doaj.org/article/65cc9e304d954539911576e67fe55632
Autor:
Panagiotis F. Christopoulos, Torleif T. Gjølberg, Stig Krüger, Guttorm Haraldsen, Jan Terje Andersen, Eirik Sundlisæter
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The Notch signaling pathway regulates developmental cell-fate decisions and has recently also been linked to inflammatory diseases. Although therapies targeting Notch signaling in inflammation in theory are attractive, their design and implementation
Externí odkaz:
https://doaj.org/article/b0851567299d445eb88111fee41934df
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
There are several reasons to consider the role of endothelial cells in COVID-19 and other emerging viral infections. First, severe cases of COVID-19 show a common breakdown of central vascular functions. Second, SARS-CoV-2 replicates in endothelial c
Externí odkaz:
https://doaj.org/article/14487dfb9f50415a882d574050b1d9a4
Autor:
Jonas Aakre Wik, Peter Lundbäck, Lars la Cour Poulsen, Guttorm Haraldsen, Bjørn Steen Skålhegg, Johanna Hol
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229395 (2020)
Inhibition of the key glycolytic activator 6-phosphofructokinase 2/fructose-2,6-bisphosphatase-3 (PFKFB3) by 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) strongly attenuates pathological angiogenesis in cancer and inflammation. In addition to
Externí odkaz:
https://doaj.org/article/0408175e543a48f4a3261012f19cb1d2