Continuous precipitation-filtration process for initial capture of a monoclonal antibody product using a four-stage countercurrent hollow fiber membrane washing step.

Autor: Minervini M; Department of Chemical Engineering, The Pennsylvania State University, State College, Pennsylvania, USA., Mergy M; Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA., Zhu Y; Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA., Gutierrez Diaz MA; Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA., Pointer C; ChromaTan, Inc., Gwynedd, Pennsylvania, USA., Shinkazh O; ChromaTan, Inc., Gwynedd, Pennsylvania, USA., Oppenheim SF; Takeda Pharmaceuticals, Cambridge, Massachusetts, USA., Cramer SM; Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA., Przybycien TM; Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA., Zydney AL; Department of Chemical Engineering, The Pennsylvania State University, State College, Pennsylvania, USA.

Publikováno v: Biotechnology and bioengineering [Biotechnol Bioeng] 2024 Aug; Vol. 121 (8), pp. 2258-2268. Date of Electronic Publication: 2023 Aug 10.