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Disease-relevant β 2 -microglobulin variants share a common amyloid fold.

Autor: Wilkinson M; Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK., Gallardo RU; Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.; Aelin Therapeutics, Bio-Incubator Leuven, Gaston Geenslaan 1, 3001, Leuven, Belgium., Martinez RM; Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.; Peak Proteins, Birchwood House, Larkwood Way, Macclesfield, Cheshire, SK10 2XR, UK., Guthertz N; Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.; Bicycle Therapeutics, Blocks A & B, Portway Building, Grant Park, Abingdon, Cambridge, CB21 6GS, UK., So M; Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.; Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan., Aubrey LD; Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK., Radford SE; Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK. s.e.radford@leeds.ac.uk., Ranson NA; Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK. n.a.ranson@leeds.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2023 Mar 02; Vol. 14 (1), pp. 1190. Date of Electronic Publication: 2023 Mar 02.

Redox signaling by the RNA polymerase III TFIIB-related factor Brf2

Autor: Gouge, Jerome, Satia, K., Guthertz, N., Widya, M., Thompson, A.J., Cousin, P., Dergai, O., Hernandez, N., Vannini, A.

Publikováno v: 'Cell ', vol: 163, pages: 1375-1387 (2015)
Cell
Cell, vol. 163, no. 6, pp. 1375-1387

Summary TFIIB-related factor 2 (Brf2) is a member of the family of TFIIB-like core transcription factors. Brf2 recruits RNA polymerase (Pol) III to type III gene-external promoters, including the U6 spliceosomal RNA and selenocysteine tRNA genes. Fou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7d2ec91dc8432e6237e1834b3cc28ced
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:42911

Modulation of Amyloidogenic Protein Self-Assembly Using Tethered Small Molecules.

Autor: Cawood EE; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.; School of Chemistry, University of Leeds, Leeds LS2 9JT, United Kingdom.; School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom., Guthertz N; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.; School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom., Ebo JS; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.; School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom., Karamanos TK; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.; School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States., Radford SE; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.; School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom., Wilson AJ; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.; School of Chemistry, University of Leeds, Leeds LS2 9JT, United Kingdom.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2020 Dec 09; Vol. 142 (49), pp. 20845-20854. Date of Electronic Publication: 2020 Nov 30.

Using protein engineering to understand and modulate aggregation.

Autor: Ebo JS; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK., Guthertz N; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK., Radford SE; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK., Brockwell DJ; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK. Electronic address: D.J.Brockwell@leeds.ac.uk.

Publikováno v: Current opinion in structural biology [Curr Opin Struct Biol] 2020 Feb; Vol. 60, pp. 157-166. Date of Electronic Publication: 2020 Feb 19.