Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro

Autor: Köppen, Janett, Schulze, Anja, Machner, Lisa, Wermann, Michael, Eichentopf, Rico, Guthardt, Max, Hähnel, Angelika, Klehm, Jessica, Kriegeskorte, Marie-Christin, Hartlage-Rübsamen, Maike, Morawski, Markus, von Hörsten, Stephan, Demuth, Hans-Ulrich, Roßner, Steffen, Schilling, Stephan

Alzheimer's disease (AD) and Parkinson's disease (PD), including dementia with Lewy bodies (DLB), account for the majority of dementia cases worldwide. Interestingly, a significant number of patients have clinical and neuropathological features of bo

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Extracellular Vesicles of Mesenchymal Stromal Cells Can be Taken Up by Microglial Cells and Partially Prevent the Stimulation Induced by β-amyloid.

Autor: Kaniowska, Dorota, Wenk, Kerstin, Rademacher, Phil, Weiss, Ronald, Fabian, Claire, Schulz, Isabell, Guthardt, Max, Lange, Franziska, Greiser, Sebastian, Schmidt, Matthias, Braumann, Ulf-Dietrich, Emmrich, Frank, Koehl, Ulrike, Jaimes, Yarúa

Publikováno v: Stem Cell Reviews & Reports; Mar2022, Vol. 18 Issue 3, p1113-1126, 14p

Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro.

Autor: Köppen J; Fraunhofer Institute of Cell Therapy and Immunology, Department of Drug Design and Target Validation IZI-MWT, 06120 Halle, Germany., Schulze A; Fraunhofer Institute of Cell Therapy and Immunology, Department of Drug Design and Target Validation IZI-MWT, 06120 Halle, Germany., Machner L; Fraunhofer Institute of Cell Therapy and Immunology, Department of Drug Design and Target Validation IZI-MWT, 06120 Halle, Germany., Wermann M; Fraunhofer Institute of Cell Therapy and Immunology, Department of Drug Design and Target Validation IZI-MWT, 06120 Halle, Germany., Eichentopf R; Fraunhofer Institute of Cell Therapy and Immunology, Department of Drug Design and Target Validation IZI-MWT, 06120 Halle, Germany., Guthardt M; Fraunhofer Institute of Cell Therapy and Immunology IZI, 04103 Leipzig, Germany., Hähnel A; Fraunhofer Institute for Microstructure of Materials and Systems IMWS, 06120 Halle, Germany., Klehm J; Fraunhofer Institute for Microstructure of Materials and Systems IMWS, 06120 Halle, Germany., Kriegeskorte MC; Paul Flechsig Institute of Brain Research, University of Leipzig, 04109 Leipzig, Germany., Hartlage-Rübsamen M; Paul Flechsig Institute of Brain Research, University of Leipzig, 04109 Leipzig, Germany., Morawski M; Paul Flechsig Institute of Brain Research, University of Leipzig, 04109 Leipzig, Germany., von Hörsten S; Friedrich-Alexander-University Erlangen-Nürnberg, Preclinical Experimental Center, 91054 Erlangen, Germany., Demuth HU; Fraunhofer Institute of Cell Therapy and Immunology, Department of Drug Design and Target Validation IZI-MWT, 06120 Halle, Germany., Roßner S; Paul Flechsig Institute of Brain Research, University of Leipzig, 04109 Leipzig, Germany., Schilling S; Fraunhofer Institute of Cell Therapy and Immunology, Department of Drug Design and Target Validation IZI-MWT, 06120 Halle, Germany.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2020 Jan 29; Vol. 25 (3). Date of Electronic Publication: 2020 Jan 29.