Identification of the Protein Receptor Binding Site of Botulinum Neurotoxins B and G Proves the Double-Receptor Concept

Autor: Rummel, Andreas, Eichner, Timo, Weil, Tanja, Karnath, Tino, Gutcaits, Aleksandrs, Mahrhold, Stefan, Sandhoff, Konrad, Proia, Richard L., Acharya, K. Ravi, Bigalke, Hans, Binz, Thomas

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2007 Jan 01. 104(1), 359-364.

Externí odkaz: https://www.jstor.org/stable/25426102

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Allosteric Modulation of Family 3 GPCRs

Autor: Aleksandrs Gutcaits, Chris G. Parsons, Tanja Weil, Tobias Noeske

Publikováno v: QSAR & Combinatorial Science. 25:134-146

This article reviews recent advances towards an understanding of the transmembrane structure, its activation and binding sites of family 3 G-Protein-Coupled Receptors (3-GPCRs). First, the prediction of their 3D structure via homology models based on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8cb35230825dc1932daf202fb0f36b10
https://doi.org/10.1002/qsar.200510139

Advances in GPCR Modeling Evaluated by the GPCR Dock 2013 Assessment: Meeting New Challenges

Autor: Camillo Rosano, Jie Xia, David Rodriguez, Manuel Pastor, Stefano Moro, Ajit Jadhav, Balaji Selvam, Sebastien Fiorucci, Ingebrigt Sylte, Serge Antonczak, Vsevolod Katritch, Serdar Durdagi, Ki Chul Park, Gerard Van Westen, Henri Xhaard, Raymond Stevens, Jiye Shi, Philip Biggin, Davide Sabbadin, SHUGUANG YUAN, Slawomir Filipek, David Gloriam, Antonella Ciancetta, Marek Bajda, Supriyo Bhattacharya, Hahnbeom Park, Jens Carlsson, Aleksandrs Gutcaits, Bartosz Trzaskowski, Jianyi Yang, William Pitt, Dorota Latek, Liliana Halip, Elizabeth Nguyen, Irina Kufareva, Noel Southall, Joaquin Ambia, Woong-Hee Shin, Jana Selent, Uddhavesh Sonavane, Marco Ponassi, Julien Diharce, Jose Manuel Perez-Aguilar, Nicos Petasis, Sergei Grudinin

Publikováno v: Structure
Structure, Elsevier (Cell Press), 2014, 22 (8), pp.1120-1139. ⟨10.1016/j.str.2014.06.012⟩
Structure Fold Design
Structure, 2014, 22 (8), pp.1120-1139. ⟨10.1016/j.str.2014.06.012⟩
Structure (London, England : 1993), vol 22, iss 8

International audience; Despite tremendous successes of GPCR crystallography, the receptors with available structures represent only a small fraction of human GPCRs. An important role of the modeling community is to maximize structural insights for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422429330d92f002e3e5f7e27319a9f5
https://doi.org/10.1016/j.str.2014.06.012

Meldonium, as a potential neuroprotective agent, promotes neuronal survival by protecting mitochondria in cerebral ischemia–reperfusion injury.

Autor: Yang, Weijie¹ (AUTHOR), Lei, Xiuxing² (AUTHOR), Liu, Fengying¹ (AUTHOR), Sui, Xin¹ (AUTHOR), Yang, Yi¹ (AUTHOR), Xiao, Zhenyu¹ (AUTHOR), cui, Ziqi¹ (AUTHOR), Sun, Yangyang¹ (AUTHOR), Yang, Jun¹ (AUTHOR), Yang, Xinyi¹ (AUTHOR), Lin, Xueyang¹ (AUTHOR), Bao, Zhenghao¹ (AUTHOR), Li, Weidong¹ (AUTHOR), Ma, Yingkai¹ (AUTHOR), Wang, Yongan¹ (AUTHOR) yonganw@126.com, Luo, Yuan¹ (AUTHOR) luoyuan2006@163.com

Publikováno v: Journal of Translational Medicine. 8/15/2024, Vol. 22 Issue 1, p1-19. 19p.