Targeting interleukin-2 to the bone marrow stroma for therapy of acute myeloid leukemia relapsing after allogeneic hematopoietic stem cell transplantation.

Autor: Schliemann C; Department of Medicine A, Hematology and Oncology, University Hospital Muenster, Muenster, Germany., Gutbrodt KL; Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland., Kerkhoff A; Department of Medicine A, Hematology and Oncology, University Hospital Muenster, Muenster, Germany., Pohlen M; Department of Medicine A, Hematology and Oncology, University Hospital Muenster, Muenster, Germany., Wiebe S; Department of Medicine A, Hematology and Oncology, University Hospital Muenster, Muenster, Germany., Silling G; Department of Medicine A, Hematology and Oncology, University Hospital Muenster, Muenster, Germany., Angenendt L; Department of Medicine A, Hematology and Oncology, University Hospital Muenster, Muenster, Germany., Kessler T; Department of Medicine A, Hematology and Oncology, University Hospital Muenster, Muenster, Germany., Mesters RM; Department of Medicine A, Hematology and Oncology, University Hospital Muenster, Muenster, Germany., Giovannoni L; Philogen SpA, Siena, Italy., Schäfers M; Department of Nuclear Medicine, University Hospital Muenster, Muenster, Germany., Altvater B; Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany., Rossig C; Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany., Grünewald I; Gerhard-Domagk-Institute for Pathology, University Hospital Muenster, Muenster, Germany., Wardelmann E; Gerhard-Domagk-Institute for Pathology, University Hospital Muenster, Muenster, Germany., Köhler G; Gerhard-Domagk-Institute for Pathology, University Hospital Muenster, Muenster, Germany. Institute of Pathology, General Hospital Fulda, Fulda, Germany., Neri D; Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland., Stelljes M; Department of Medicine A, Hematology and Oncology, University Hospital Muenster, Muenster, Germany., Berdel WE; Department of Medicine A, Hematology and Oncology, University Hospital Muenster, Muenster, Germany. berdel@uni-muenster.de.

Publikováno v: Cancer immunology research [Cancer Immunol Res] 2015 May; Vol. 3 (5), pp. 547-56. Date of Electronic Publication: 2015 Feb 11.

A comprehensive surface proteome analysis of myeloid leukemia cell lines for therapeutic antibody development.

Autor: Strassberger V; ETH Zurich, Department of Chemistry and Applied Biosciences, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland., Gutbrodt KL; ETH Zurich, Department of Chemistry and Applied Biosciences, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland., Krall N; ETH Zurich, Department of Chemistry and Applied Biosciences, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland., Roesli C; ETH Zurich, Department of Chemistry and Applied Biosciences, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland., Takizawa H; Division of Hematology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland., Manz MG; Division of Hematology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland., Fugmann T; Philochem AG, Libernstrasse 3, 8112 Otelfingen, Switzerland. Electronic address: tim.fugmann@philochem.ch., Neri D; ETH Zurich, Department of Chemistry and Applied Biosciences, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland. Electronic address: neri@pharma.ethz.ch.

Publikováno v: Journal of proteomics [J Proteomics] 2014 Mar 17; Vol. 99, pp. 138-51. Date of Electronic Publication: 2014 Jan 30.

Antibody-based delivery of interleukin-2 to neovasculature has potent activity against acute myeloid leukemia.

Autor: Gutbrodt KL; Department of Chemistry and Applied Biosciences, ETH Zürich, Wolfgang-Pauli-Strasse 10, CH-8093 Zurich, Switzerland., Schliemann C, Giovannoni L, Frey K, Pabst T, Klapper W, Berdel WE, Neri D

Publikováno v: Science translational medicine [Sci Transl Med] 2013 Sep 04; Vol. 5 (201), pp. 201ra118.

VHL loss causes spindle misorientation and chromosome instability.

Autor: Thoma CR; Institute of Cell Biology, ETH Zurich, 8093 Zurich, Switzerland., Toso A, Gutbrodt KL, Reggi SP, Frew IJ, Schraml P, Hergovich A, Moch H, Meraldi P, Krek W

Publikováno v: Nature cell biology [Nat Cell Biol] 2009 Aug; Vol. 11 (8), pp. 994-1001. Date of Electronic Publication: 2009 Jul 20.