Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Gut-specific homing"'
Autor:
Wencheng Zheng, Jianjian Li, Chuan Qin, Yan Shi, Xiaofei Wang, Hong Zhang, Yaqian Guo, Zongde Zhang, Guang Zhao
Publikováno v:
Immunity. 44(2):330-342
Lymphocyte homing to draining lymph nodes is critical for the initiation of immune responses. Secondary lymphoid organs of germ-free mice are underdeveloped. How gut commensal microbes remotely regulate cellularity and volume of secondary lymphoid or
Autor:
Umid Kumar Shrestha
Publikováno v:
Journal of Advances in Internal Medicine. 4:16-24
The pathogens and harmless antigens from the bacterial flora and food constantly expose the mucosal surface of the gastrointestinal tract. The mucosal epithelial cells act not only as a physical barrier, but also as a local immune system, which plays
Publikováno v:
Immunity. 43(1):107-119
SummaryDistinct groups of innate lymphoid cells (ILCs) such as ILC1, ILC2, and ILC3 populate the intestine, but how these ILCs develop tissue tropism for this organ is unclear. We report that prior to migration to the intestine ILCs first undergo a
Autor:
Motohiro Kobayashi, Yasuhiro Sakai
Publikováno v:
Pathology International. 65:344-354
Chronic inflammation is a response to prolonged exposure to injurious stimuli that harm and destroy tissues and promote lymphocyte infiltration into inflamed sites. Following progressive accumulation of lymphocytes, the histology of inflamed tissue b
Autor:
Borja L. Holgado, Julia Sáez de Guinoa, Jens V. Stein, Gema Pérez-Rivero, Yolanda R. Carrasco, Carlos Cabañas, Rosa P. Gomariz, Mario Mellado, José Miguel Rodríguez-Frade, Graciela Cascio, Álvaro Gil Sanz, Silvia F. Soriano
Publikováno v:
European Journal of Immunology. 43:1745-1757
Janus kinases (JAKs) are central signaling molecules in cytokine receptor cascades. Although they have also been implicated in chemokine receptor signaling, this function continues to be debated. To address this issue, we established a nucleofection
Autor:
Sabrina Leverrier, Shenyuan L. Zhang, Ying Yu, Milton L. Greenberg, Michael D. Cahalan, Ian Parker
Publikováno v:
Greenberg, Milton L.; Yu, Ying; Leverrier, Sabrina; Zhang, Shenyuan L.; Parker, Ian; & Cahalan, Michael D.(2013). Orai1 Function is Essential for T Cell Homing to Lymph Nodes. Journal of immunology (Baltimore, Md. : 1950), 190(7), 3197-3206. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/5mq7x28r
In T lymphocytes, Ca2+ release–activated Ca2+ (CRAC) channels composed of Orai1 subunits trigger Ag-induced gene expression and cell proliferation through the NFAT pathway. We evaluated the requirement of CRAC channel function for lymphocyte homing
Autor:
Sidney M. Morris, Myung H. Kim, Shankar Thangamani, Chang H. Kim, Benjamin J. Ulrich, Jinsam Chang
Publikováno v:
European Journal of Immunology. 43:967-978
Arginase I (Arg1), an enzyme expressed by many cell types including myeloid cells, can regulate immune responses. Expression of Arg1 in myeloid cells is regulated by a number of cytokines and tissue factors that influence cell development and activat
Autor:
Sabina A. Islam, Andrew D. Luster
Publikováno v:
Nature Medicine. 18:705-715
Allergic inflammation develops in tissues that have large epithelial surface areas that are exposed to the environment, such as the lung, skin and gut. In the steady state, antigen-experienced memory T cells patrol these peripheral tissues to facilit
Autor:
Motohiro Kobayashi, Yasuhiro Sakai, Jun Nakayama, Minoru Fukuda, Hitomi Hoshino, Kenichi Suzawa
Publikováno v:
Seminars in Immunopathology. 34:401-413
Under normal and pathological conditions, lymphocyte migration into the gastrointestinal mucosa to form gut-associated lymphoid tissue is mediated by the L-selectin ligand peripheral lymph node addressin and the integrin α4β7 ligand mucosal address
Autor:
Koko Katagiri, Sayaka Ishihara, Masayuki Miyasaka, Makoto Saegusa, Eiji Umemoto, Akihiko Nishikimi
Publikováno v:
Nature Communications
Rap1-GTP activates leukocyte function-associated antigen-1 (LFA-1) to induce arrest on the high endothelial venule (HEV). Here we show that Rap1-GDP restrains rolling behaviours of T cells on the peripheral lymph node addressin (PNAd), P-selectin and