Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Gut granule"'
Autor:
Victoria Eichten, Kimberly Peloza, Greg J. Hermann, Olivia K. Foster, Marie Harp, Logan Harper, Caitlin Morris, James N Brandt, Simran Handa, Brian King, Laura Voss, Fiona M. Rambo, Amanda Maxfield, Sierra Lavoy
Publikováno v:
Genetics. 214:419-445
ABC transporters couple ATP hydrolysis to the transport of substrates across cellular membranes. This protein superfamily has diverse activities resulting from differences in their cargo and subcellular localization. Our work investigates the role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8015e4b6e583bca3bd7527e3a642373c
https://doi.org/10.1534/genetics.119.302900
https://doi.org/10.1534/genetics.119.302900
Autor:
Luca Sax, Victoria Eichten, Jackson R. Thein, Katelyn Nicholson, Lali Guevara-Hernandez, Matthew L. White, Greg J. Hermann, Fiona M. Rambo, Lydia Fairchild, Laurence Seabrook, James N Brandt, Danielia Lewis, Logan Harper, Laura Voss
Publikováno v:
Dev Biol
While the epithelial cell cortex displays profound asymmetries in protein distribution and morphology along the apico-basal axis, the extent to which the cytoplasm is similarly polarized within epithelial cells remains relatively unexplored. We show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc066f2b6a06952369fb8a0aea6896f1
https://pubmed.ncbi.nlm.nih.gov/34597675
https://pubmed.ncbi.nlm.nih.gov/34597675
Publikováno v:
Bio Protoc
Assays have been developed to study trafficking in various tissues of Caenorhabditis elegans. Adult C. elegans intestinal cells are large and have extensive endocytic networks, thus making them a good system for deciphering the endocytic pathway usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab1cfa2a503b92113197af28152ca3f
https://doi.org/10.21769/bioprotoc.2724
https://doi.org/10.21769/bioprotoc.2724
Autor:
Greg J. Hermann, Hannah Somhegyi, Thomas P. Curtin, Daniel S. Saxton, Annalise Vine, Rebecca Salesky, Olivia K. Foster, Jared L. Delahaye
Publikováno v:
Molecular Biology of the Cell
This work presents a systematic analysis of how VPS-C/HOPS, CCZ-1/SAND-1, and RAB-7, which have well-defined roles in lysosome formation, act in the biogenesis of Caenorhabditis elegans lysosome-related organelles. It identifies key molecular similar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28544f457b4c1283fa19634bf10b9c95
https://doi.org/10.1091/mbc.e13-09-0521
https://doi.org/10.1091/mbc.e13-09-0521
Autor:
Lena K. Schroeder, Brian King, Andrea L. Lawrenson, Greg J. Hermann, Aaron M. Kershner, Erin Currie
Publikováno v:
Genetics. 177:1569-1582
Caenorhabditis elegans gut granules are lysosome-related organelles with birefringent contents. mrp-4, which encodes an ATP-binding cassette (ABC) transporter homologous to mammalian multidrug resistance proteins, functions in the formation of gut gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b803afd4231cf8e125cbd608bc3c4ae
https://doi.org/10.1534/genetics.107.080689
https://doi.org/10.1534/genetics.107.080689
Autor:
Greg J. Hermann, Jennifer L. Watts, Susan Kremer, Erin Currie, Lena K. Schroeder, Andrea L. Lawrenson, Elizabeth Kwan, Maxwell Kramer
Publikováno v:
Molecular Biology of the Cell. 18:995-1008
Caenorhabditis elegans gut granules are intestine specific lysosome-related organelles with birefringent and autofluorescent contents. We identified pgp-2, which encodes an ABC transporter, in screens for genes required for the proper formation of gu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c25a5368d81ad5099ff98cf029e07b
https://doi.org/10.1091/mbc.e06-08-0685
https://doi.org/10.1091/mbc.e06-08-0685
Autor:
Caitlin Morris, Fiona M. Rambo, My Van Vo, Chonglin Yang, Greg J. Hermann, Marie Harp, Simran Handa, Youli Jian, Kimberly Peloza, Hannah Somhegyi, Laura Voss, Olivia K. Foster
Publikováno v:
PLoS Genetics, Vol 14, Iss 11, p e1007772 (2018)
PLoS Genetics
PLoS Genetics
Cell type-specific modifications of conventional endosomal trafficking pathways lead to the formation of lysosome-related organelles (LROs). C. elegans gut granules are intestinally restricted LROs that coexist with conventional degradative lysosomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779c15f224df13c000e993e24efc9f37
https://doi.org/10.1371/journal.pgen.1007772
https://doi.org/10.1371/journal.pgen.1007772
Autor:
Madeline Cole, Steven Levitte, Brian King, Micah Depper, Rebecca Salesky, Sage Coe Smith, Greg J. Hermann
Publikováno v:
FEBS Journal. 277:1420-1439
Gut granules are cell type-specific lysosome-related organelles found within the intestinal cells of Caenorhabditis elegans. To investigate the regulation of lysosome-related organelle size, we screened for C. elegans mutants with substantially enlar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f0b7df2e74b93257b9d4c0a92d6f1a8
https://doi.org/10.1111/j.1742-4658.2010.07573.x
https://doi.org/10.1111/j.1742-4658.2010.07573.x
Autor:
Aaron M. Kershner, Lena K. Schroeder, Beverley M. Rabbitts, Caroline A. Hieb, Greg J. Hermann, Paul Fonarev, James R. Priess, Barth D. Grant
Publikováno v:
Molecular Biology of the Cell. 16:3273-3288
The intestinal cells of Caenorhabditis elegans embryos contain prominent, birefringent gut granules that we show are lysosome-related organelles. Gut granules are labeled by lysosomal markers, and their formation is disrupted in embryos depleted of A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76bc6d00babd578ce7ba2da3f34cad1
https://doi.org/10.1091/mbc.e05-01-0060
https://doi.org/10.1091/mbc.e05-01-0060
Publikováno v:
Developmental Biology. 216(1):114-134
The intestine of Caenorhabditis elegans is an epithelial tube consisting of only 20 cells and is derived clonally from a single embryonic blastomere called E. We describe the cellular events that shape the intestine. These events include cytoplasmic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6791a80a4a08ba94f01065af2eea901