Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Gustavo de Alencastro"'
Autor:
Gustavo de Alencastro
Publikováno v:
Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.
Neste trabalho utilizamos diferentes abordagens para o estudo de genes associados com desenvolvimento e funcionamento do SNC assim como com doenças neurológicas: 1) uma das abordagens consistiu na identificação do alelo associado a uma forma de r
Autor:
Shinnosuke Tsuji, Calvin J. Stephens, Giulia Bortolussi, Feijie Zhang, Gabriele Baj, Hagoon Jang, Gustavo de Alencastro, Andrés F. Muro, Katja Pekrun, Mark A. Kay
Homologous recombination (HR)-based gene therapy using adeno-associated viruses (AAV-HR) without nucleases has several advantages over classic gene therapy, especially the potential for permanent transgene expression. However, the low efficiency of A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b28977fb37869e8d09fd780d2efe38
http://hdl.handle.net/11368/3026084
http://hdl.handle.net/11368/3026084
Autor:
Gustavo de Alencastro, Giulia Bortolussi, Mark A. Kay, Calvin Stevens, Andrés F. Muro, Feijie Zhang, Katja Pekrun, Shinnosuke Tsuji, Gabriele Baj
Recombinant adeno-associated viral (rAAV) vectors continue to gain popularity for in vivo therapeutic gene delivery. Homologous recombination-based gene therapy using rAAV (AAV-HR) without nucleases has several advantages over classical gene therapy,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::221c0e61e18c7cc9a70c91495bb3b422
https://doi.org/10.21203/rs.3.rs-106148/v1
https://doi.org/10.21203/rs.3.rs-106148/v1
Autor:
Feijie Zhang, Matthew Tiffany, Ruhikanta A. Meetei, M. Kyle Cromer, Karim Majzoub, Mara Pavel-Dinu, Sirika Pillay, Adam Sheikali, Jan E. Carette, Mark A. Kay, Katja Pekrun, Francesco Puzzo, Hagoon Jang, Gustavo de Alencastro, Matthew H. Porteus
Publikováno v:
Mol Ther
Recombinant adeno-associated virus (rAAV) vectors have the unique property of being able to perform genomic targeted integration (TI) without inducing a double-strand break (DSB). In order to improve our understanding of the mechanism behind TI media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35065181d1261c0a3966f7b32e3ee768
https://europepmc.org/articles/PMC7934449/
https://europepmc.org/articles/PMC7934449/
Autor:
Mark A. Kay, Jianpeng Xu, Gustavo de Alencastro, Katja Pekrun, Paul N. Valdmanis, Matthew Tiffany
Publikováno v:
Hum Gene Ther
Despite early successes using recombinant adeno-associated virus (rAAV) vectors in clinical gene therapy trials, limitations remain making additional advancements a necessity. Some of the challenges include variable levels of pre-existing neutralizin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1034075e33d4e1c8ac18d6fdf1771c4
https://europepmc.org/articles/PMC7232707/
https://europepmc.org/articles/PMC7232707/
Autor:
Youngjin Kim, Ren Song, Sean Nygaard, Jun Liu, Markus Grompe, Qing-Jun Luo, Matthew Tiffany, Matthias Hebrok, Feorillo Galivo, Gustavo de Alencastro, Mark A. Kay, Jianpeng Xu, Katja Pekrun, Feijie Zhang
Publikováno v:
JCI insight, vol 4, iss 22
While gene transfer using recombinant adeno-associated viral (rAAV) vectors has shown success in some clinical trials, there remain many tissues that are not well transduced. Because of the recent success in reprogramming islet-derived cells into fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7d35b15f0dfd5644ef9c8e4a344e76
https://doi.org/10.1172/jci.insight.131610
https://doi.org/10.1172/jci.insight.131610
Autor:
Sean Nygaard, Ren Song, Feijie Zhang, Jun Liu, Qing-Jun Luo, Mark A. Kay, Matthias Hebrok, Jianpeng Xu, Markus Grompe, Youngjin Kim, Matthew Tiffany, Katja Pekrun, Gustavo de Alencastro, Feorillo Galivo
While gene transfer using recombinant adeno-associated viral (rAAV) vectors have shown success in some clinical trials, there remain many tissues that are not well transduced. Because of the recent success in reprogramming islet derived cells into fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a06e6370b178e16a228e55f7e0983af
https://doi.org/10.1101/683672
https://doi.org/10.1101/683672
Autor:
Vanessa Jones, Melinda Power, Joshua B. Studdert, Angelyn Hor, Kirsten A. Steiner, Yoji Kojima, David A.F. Loebel, Patrick P.L. Tam, Oliver H. Tam, Grant J Logan, Erdahl Teber, Keren Kaufman-Francis, Hilda A. Pickett, Gustavo de Alencastro, Michael D. Stutz, Ian E. Alexander
Publikováno v:
Cell Stem Cell. 14:107-120
SummaryMouse epiblast stem cells (EpiSCs) can be derived from a wide range of developmental stages. To characterize and compare EpiSCs with different origins, we derived a series of EpiSC lines from pregastrula stage to late-bud-stage mouse embryos.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a243ca14440a8925fa61810f14ef7d7d
https://doi.org/10.1016/j.stem.2013.09.014
https://doi.org/10.1016/j.stem.2013.09.014
Autor:
Gustavo de Alencastro
Publikováno v:
Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Neste trabalho utilizamos diferentes abordagens para o estudo de genes associados com desenvolvimento e funcionamento do SNC assim como com doenças neurológicas: 1) uma das abordagens consistiu na identificação do alelo associado a uma forma de r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc742d6d142038df76e226215b484538
https://doi.org/10.11606/d.41.2008.tde-28012009-130812
https://doi.org/10.11606/d.41.2008.tde-28012009-130812
Publikováno v:
Molecular Therapy. 23
Recombinant adeno-associated viral (rAAV) vectors constitute one of the most promising tools for gene transfer. Desired properties include the lack of pathogenicity in humans, broad tissue tropism, ability to transduce both dividing and non-dividing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfadc8a6060cbabab9797805974017d8