Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Gustavo M Silva"'
Autor:
Alberto Malvezzi, Patrícia M Higa, Antonia T-do Amaral, Gustavo M Silva, Fabio C Gozzo, Emer S Ferro, Leandro M Castro, Leandro de Rezende, Gisele Monteiro, Marilene Demasi
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39408 (2012)
Thimet oligopeptidase (EP24.15) is a cysteine-rich metallopeptidase containing fifteen Cys residues and no intra-protein disulfide bonds. Previous work on this enzyme revealed that the oxidative oligomerization of EP24.15 is triggered by S-glutathiol
Externí odkaz:
https://doaj.org/article/d1eb6ac02a524b949c397368b1d21451
Autor:
Sezen Meydan, Géssica C. Barros, Vanessa Simões, Lana Harley, Blanche K. Cizubu, Nicholas R. Guydosh, Gustavo M. Silva
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113359- (2023)
Summary: Oxidative stress causes K63-linked ubiquitination of ribosomes by the E2 ubiquitin conjugase Rad6. How Rad6-mediated ubiquitination of ribosomes affects translation, however, is unclear. We therefore perform Ribo-seq and Disome-seq in Saccha
Externí odkaz:
https://doaj.org/article/60c50936146e4876a458eb95a3f76dfc
Autor:
Patricia L.M. Dahia, Ricardo C.T. Aguiar, Yidong Chen, Robert L. Reddick, Jan Bruder, Marta Barontini, Neil Aronin, Sarika Rao, I. Tolgay Ocal, Manju L. Prasad, Gustavo M. Silva, Shintaro Iwata, Qing Gao, Zi-Ming Cheng, Yuejuan Qin, Rodrigo A. Toledo
Supplementary Appendix: List of all supplementary data files; Supplemental Methods: Additional clinical details of Samples, and details of whole exome sequencing, targeted sequencing and in silico structure modeling not included in main article
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62fadc0665be6fa207fdff19736c5c9c
https://doi.org/10.1158/1078-0432.22457802.v1
https://doi.org/10.1158/1078-0432.22457802.v1
Autor:
Patricia L.M. Dahia, Ricardo C.T. Aguiar, Yidong Chen, Robert L. Reddick, Jan Bruder, Marta Barontini, Neil Aronin, Sarika Rao, I. Tolgay Ocal, Manju L. Prasad, Gustavo M. Silva, Shintaro Iwata, Qing Gao, Zi-Ming Cheng, Yuejuan Qin, Rodrigo A. Toledo
Purpose: Pheochromocytomas and paragangliomas (PPGL) are genetically heterogeneous tumors of neural crest origin, but the molecular basis of most PPGLs is unknown.Experimental Design: We performed exome or transcriptome sequencing of 43 samples from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c258e7c083018896e91674880a4ec87
https://doi.org/10.1158/1078-0432.c.6523701.v1
https://doi.org/10.1158/1078-0432.c.6523701.v1
Autor:
Patricia L.M. Dahia, Ricardo C.T. Aguiar, Yidong Chen, Robert L. Reddick, Jan Bruder, Marta Barontini, Neil Aronin, Sarika Rao, I. Tolgay Ocal, Manju L. Prasad, Gustavo M. Silva, Shintaro Iwata, Qing Gao, Zi-Ming Cheng, Yuejuan Qin, Rodrigo A. Toledo
Supplemental Figure 1: Alternative views of Figure 1 displaying mutations in our cohort; Supplemental Figure 2: Histone 3.3 G34W mutation in patient samples; Supplemental Figure 3: In silico analysis of histone 3.3 and G34W mutant; Supplemental Figur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9318cf4ace5911fb2633c48d842a6d
https://doi.org/10.1158/1078-0432.22457808
https://doi.org/10.1158/1078-0432.22457808
Autor:
Patricia L.M. Dahia, Ricardo C.T. Aguiar, Yidong Chen, Robert L. Reddick, Jan Bruder, Marta Barontini, Neil Aronin, Sarika Rao, I. Tolgay Ocal, Manju L. Prasad, Gustavo M. Silva, Shintaro Iwata, Qing Gao, Zi-Ming Cheng, Yuejuan Qin, Rodrigo A. Toledo
Table S1: Features of the 41 samples of the next-generation sequencing (NGS) cohort; Table S2: Mutations identified in known pheochromocytoma/paraganglioma-related genes in the NGS cohort; Table S3: Features of the validation cohort of 136 pheochromo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dab9b55fb4482a505f320c3c03a2880
https://doi.org/10.1158/1078-0432.22457805.v1
https://doi.org/10.1158/1078-0432.22457805.v1
Autor:
Sezen Meydan, Géssica C. Barros, Vanessa Simões, Lana Harley, Blanche K. Cizubu, Nicholas R. Guydosh, Gustavo M. Silva
SUMMARYOxidative stress causes K63-linked ubiquitination of ribosomes by the E2 ubiquitin conjugase, Rad6. How Rad6-mediated ubiquitination of ribosomes affects global translation, however, is unclear. We therefore performed Ribo-seq and Disome-seq i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87c48565ccf870f707829c0bf72e1fcc
https://doi.org/10.1101/2022.09.27.509727
https://doi.org/10.1101/2022.09.27.509727
Autor:
Marilene Demasi, Luis E.S. Netto, Gustavo M. Silva, Adrian Hand, Cristiano L.P. de Oliveira, Renata N. Bicev, Fabio Gozzo, Mario H. Barros, Janaina M.M. Leme, Erina Ohara
Publikováno v:
Redox Biology, Vol 2, Iss C, Pp 44-51 (2014)
The proteasome is a multimeric and multicatalytic intracellular protease responsible for the degradation of proteins involved in cell cycle control, various signaling processes, antigen presentation, and control of protein synthesis. The central cata
Externí odkaz:
https://doaj.org/article/8705eacd193847ac82bd96607c0ccc85
Autor:
Gustavo M. Silva
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1711622113b7173abe8c581904047ec3
https://doi.org/10.1096/fasebj.2022.36.s1.0i206
https://doi.org/10.1096/fasebj.2022.36.s1.0i206
Autor:
Vanessa Simões, Blanche K. Cizubu, Lana Harley, Ye Zhou, Joshua Pajak, Nathan A. Snyder, Jonathan Bouvette, Mario J. Borgnia, Gaurav Arya, Alberto Bartesaghi, Gustavo M. Silva
Publikováno v:
Cell reports. 39(8)
Protein ubiquitination is an essential process that rapidly regulates protein synthesis, function, and fate in dynamic environments. Within its non-proteolytic functions, we showed that K63-linked polyubiquitinated conjugates heavily accumulate in ye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb1e691295d8f9d5691bc3a39a6b538
https://pubmed.ncbi.nlm.nih.gov/35613580
https://pubmed.ncbi.nlm.nih.gov/35613580