Zobrazeno 1 - 10
of 228
pro vyhledávání: '"Gustavo F Doncel"'
Autor:
Andrea R Thurman, Vivian Brache, Leila Cochon, Louise A Ouattara, Neelima Chandra, Terry Jacot, Nazita Yousefieh, Meredith R Clark, Melissa Peet, Homaira Hanif, Jill L Schwartz, Susan Ju, Mark A Marzinke, David W Erikson, Urvi Parikh, Betsy C Herold, Raina N Fichorova, Elizabeth Tolley, Gustavo F Doncel
Publikováno v:
PLoS ONE, Vol 17, Iss 10, p e0275794 (2022)
Multipurpose prevention technologies (MPTs), which prevent sexually transmitted infection(s) and unintended pregnancy, are highly desirable to women. In this randomized, placebo-controlled, phase I study, women used a placebo or tenofovir (TFV) and l
Externí odkaz:
https://doaj.org/article/12b9e0d7bc744748b0aa37356ba5345c
Autor:
Seth Zissette, Elizabeth E Tolley, Andres Martinez, Homaira Hanif, Katherine Gill, Nelly Mugo, Laura Myers, Ednar Casmir, Menna Duyver, Kenneth Ngure, Gustavo F Doncel
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251823 (2021)
IntroductionOral, vaginal and other pre-exposure prophylaxis (PrEP) products for HIV prevention are in various stages of development. Low adherence poses a serious challenge to successful evaluation in trials. In a previous study, we developed tools
Externí odkaz:
https://doaj.org/article/b2d902d873f147d580fad67ae332ba2f
Autor:
Raina N Fichorova, Charles S Morrison, Pai-Lien Chen, Hidemi S Yamamoto, Yashini Govender, Damilola Junaid, Stanthia Ryan, Cynthia Kwok, Tsungai Chipato, Robert A Salata, Gustavo F Doncel
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0224359 (2020)
Sexually transmitted infections (STIs) and vaginal dysbiosis (disturbed resident microbiota presenting with abnormal Nugent score or candidiasis) have been associated with mucosal inflammation and risk of HIV-1 infection, cancer and poor reproductive
Externí odkaz:
https://doaj.org/article/2de41876a0444b3fae77e4ffb1f7ad53
Autor:
Andrea Ries Thurman, Jill L Schwartz, Jacques Ravel, Pawel Gajer, Mark A Marzinke, Nazita Yousefieh, Sharon M Anderson, Gustavo F Doncel
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217229 (2019)
Recent data support that the vaginal microbiota may alter mucosal pharmacokinetics (PK) of topically delivered microbicides. Our team developed an intravaginal ring (IVR) that delivers tenofovir (TFV) (8-10 mg/day) alone or with levonorgestrel (LNG)
Externí odkaz:
https://doaj.org/article/029017ba10454a1b8fb738a0c6d42a01
Autor:
Andrea Ries Thurman, Jill L Schwartz, Vivian Brache, Meredith R Clark, Timothy McCormick, Neelima Chandra, Mark A Marzinke, Frank Z Stanczyk, Charlene S Dezzutti, Sharon L Hillier, Betsy C Herold, Raina Fichorova, Susana N Asin, Christiane Rollenhagen, Debra Weiner, Patrick Kiser, Gustavo F Doncel
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199778 (2018)
To prevent the global health burdens of human immunodeficiency virus [HIV] and unintended/mistimed pregnancies, we developed an intravaginal ring [IVR] that delivers tenofovir [TFV] at ~10mg/day alone or with levonorgestrel [LNG] at ~20μg/day for 90
Externí odkaz:
https://doaj.org/article/c39f9bf68c2b4ca7985740b682784d02
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197906 (2018)
BACKGROUND:The topical HIV prevention (microbicides) field is in acute need of a method to rapidly and objectively measure adherence to product use in clinical trials. Infrared (IR) spectroscopy has been used in many pharmaceutical and forensic appli
Externí odkaz:
https://doaj.org/article/4d6aef2709c34b6b97252e6812d4186e
Autor:
Christiane Rollenhagen, Sherrill L Macura, Melissa J Lathrop, Todd A Mackenzie, Gustavo F Doncel, Susana N Asin
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131919 (2015)
Establishment of a productive HIV-1 infection in the female reproductive tract likely depends on the balance between anti-viral and pro-inflammatory responses leading to activation and proliferation of HIV target cells. Immune modulators that boost a
Externí odkaz:
https://doaj.org/article/6fbf9e34c1394213b933d839bef436dd
Autor:
Irina A Zalenskaya, Theresa Joseph, Jasmin Bavarva, Nazita Yousefieh, Suzanne S Jackson, Titilayo Fashemi, Hidemi S Yamamoto, Robert Settlage, Raina N Fichorova, Gustavo F Doncel
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128557 (2015)
Inflammation and immune activation of the cervicovaginal mucosa are considered factors that increase susceptibility to HIV infection. Therefore, it is essential to screen candidate anti-HIV microbicides for potential mucosal immunomodulatory/inflamma
Externí odkaz:
https://doaj.org/article/09b02aa94a424870a29f674be840edd1
Autor:
Terry A Jacot, Ashley Nelson, Andrea Thurman, Angela D M Kashuba, David F Archer, Gustavo F Doncel
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114368 (2014)
Poor and inconsistent use of study products has hindered clinical HIV prevention studies. It is important to be able to monitor product adherence and protocol compliance in order to determine microbicide efficacy and safety more accurately. Current m
Externí odkaz:
https://doaj.org/article/bb4acd68a46948c1a852819e054a5b97
Autor:
Theodore J Segarra, Esra Fakioglu, Natalia Cheshenko, Sarah S Wilson, Pedro M M Mesquita, Gustavo F Doncel, Betsy C Herold
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27675 (2011)
Despite significant protection in preclinical studies, cellulose sulfate (CS) failed to protect women against HIV-1/2 and was associated with a trend toward increased HIV-1 acquisition in one of the clinical trials. These results highlight the need f
Externí odkaz:
https://doaj.org/article/ccdb1e43128149ad8ab4505d20b95979