Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Gustavo Egea"'
Autor:
Gustavo Egea
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101196- (2024)
Externí odkaz:
https://doaj.org/article/fd35d681b5bd4040b009f94ebcbf93b0
Autor:
Aleksandra Mas-Stachurska, Gustavo Egea, Rianne de Bruin-Bon, Paula Rudenick, Laura Sanchis, Berto J. Bouma, Barbara J. Mulder, Bart Bijnens, Marta Sitges
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The mechanisms leading to cardiac remodeling in Marfan syndrome (MFS) are a matter of debate since it could be either due to structural dysfunction of the myocardial extracellular matrix or to increased afterload caused by the dilated aorta.
Externí odkaz:
https://doaj.org/article/b0f692e82db944b9b8321f9cfaf42029
Autor:
Isaac Rodríguez-Rovira, Angela López-Sainz, Maria Encarnación Palomo-Buitrago, Belen Pérez, Francesc Jiménez-Altayó, Victoria Campuzano, Gustavo Egea
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11293 (2023)
Redox stress is involved in the aortic aneurysm pathogenesis in Marfan syndrome (MFS). We recently reported that allopurinol, a xanthine oxidoreductase inhibitor, blocked aortopathy in a MFS mouse model acting as an antioxidant without altering uric
Externí odkaz:
https://doaj.org/article/928502543dab4514832e91d0b751efc6
Autor:
Noura Abdalla, Ester Tobías-Baraja, Alejandro Gonzalez, Gloria Garrabou, Gustavo Egea, Victoria Campuzano
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 10071 (2023)
Williams–Beuren syndrome (WBS) is a rare neurodevelopmental disorder that, together with a rather characteristic neurocognitive profile, presents a strong cardiovascular phenotype. The cardiovascular features of WBS are mainly related to a gene dos
Externí odkaz:
https://doaj.org/article/6d1ae4da82b840238b68390a5418a854
Autor:
Noura Abdalla, Paula Ortiz-Romero, Isaac Rodriguez-Rovira, Luis A. Pérez-Jurado, Gustavo Egea, Victoria Campuzano
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3261 (2023)
Williams–Beuren syndrome (WBS) is a rare disorder caused by a recurrent microdeletion with hallmarks of cardiovascular manifestations, mainly supra-valvular aortic stenosis (SVAS). Unfortunately, there is currently no efficient treatment. We invest
Externí odkaz:
https://doaj.org/article/4014e8f5f18542cba2ec5f801e03f721
Autor:
Paula Ortiz-Romero, Alejandro González-Simón, Gustavo Egea, Luis A. Pérez-Jurado, Victoria Campuzano
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Williams–Beuren syndrome (WBS) is a rare neurodevelopmental disorder characterized by a distinctive cognitive phenotype for which there are currently no effective treatments. We investigated the progression of behavioral deficits present in WBS com
Externí odkaz:
https://doaj.org/article/be145bfe15ff483e9bcba89e641ade63
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract In Marfan syndrome, the tunica media is disrupted, which leads to the formation of ascending aortic aneurysms. Marfan aortic samples are histologically characterized by the fragmentation of elastic laminae. However, conventional histological
Externí odkaz:
https://doaj.org/article/7910d0dc307d4d15880b3866975d6f2e
Publikováno v:
Antioxidants, Vol 9, Iss 10, p 1013 (2020)
Connective tissue is known to provide structural and functional “glue” properties to other tissues. It contains cellular and molecular components that are arranged in several dynamic organizations. Connective tissue is the focus of numerous genet
Externí odkaz:
https://doaj.org/article/7b643d7631c445419c4adbffe9a83ed1
Autor:
Gianluca L. Perrucci, Erica Rurali, Maria Corlianò, Maria Balzo, Michela Piccoli, Donato Moschetta, Alessandro Pini, Raffaella Gaetano, Carlo Antona, Gustavo Egea, Gunter Fischer, Miroslav Malešević, Francesco Alamanni, Elisa Cogliati, Adolfo Paolin, Giulio Pompilio, Patrizia Nigro
Publikováno v:
Cells, Vol 9, Iss 1, p 154 (2020)
Background: Marfan syndrome (MFS) is a genetic disease, characterized by thoracic aortic aneurysm (TAA), which treatment is to date purely surgical. Understanding of novel molecular targets is mandatory to unveil effective pharmacological approaches.
Externí odkaz:
https://doaj.org/article/13b419b378ad4306b254379f0d9e48c8
Autor:
Francesc Jiménez-Altayó, Anna-Maria Siegert, Fabio Bonorino, Thayna Meirelles, Laura Barberà, Ana P. Dantas, Elisabet Vila, Gustavo Egea
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Marfan syndrome (MFS) is a hereditary disorder of the connective tissue that causes life-threatening aortic aneurysm, which initiates at the aortic root and can progress into the ascending portion. However, analysis of ascending aorta reactivity in a
Externí odkaz:
https://doaj.org/article/05cfa4a94be74e11b9ec59c099ef0547