Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Gustavo D. Aguirre"'
Autor:
Raghavi Sudharsan, Jennifer Kwok, Malgorzata Swider, Alexander Sumaroka, Gustavo D. Aguirre, Artur V. Cideciyan, William A. Beltran
Publikováno v:
Cell Death and Disease, Vol 15, Iss 9, Pp 1-10 (2024)
Abstract PRLΔE1, a retina-specific isoform of prolactin, is expressed in multiple and diverse forms of canine inherited retinal degeneration (IRD). We find that while PRLΔE1 expression in rods is not associated with the initial phase of disease cha
Externí odkaz:
https://doaj.org/article/e37984bba17c4ae580d9b5b917c7b0d9
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 31-47 (2023)
Mutations in the retina-specific isoform of the gene encoding retinitis pigmentosa GTPase regulator (RPGRorf15) cause X-linked retinitis pigmentosa, a severe and early onset inherited retinal degeneration. The underlying pathogenic mechanisms and var
Externí odkaz:
https://doaj.org/article/0f3d65e8d5ae492da53e4544ce2e6753
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Photoreceptors possess a highly specialized primary cilium containing expanded ciliary membrane discs called the outer segment. The photoreceptor cilium is essential for the maintenance of the outer segment, and pathogenic variants in more than 50 ci
Externí odkaz:
https://doaj.org/article/47c2a4ad9d1a4f9ba9f1f48b167f0482
Autor:
Raghavi Sudharsan, Leonardo Murgiano, Hsin-Yao Tang, Timothy W. Olsen, Venkata R. M. Chavali, Gustavo D. Aguirre, William A. Beltran
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Prolactin (PRL) hormone functions as a pleiotropic cytokine with a protective role in the retina. We recently identified by transcriptome profiling that PRL is one of the most highly upregulated mRNAs in the retinas of mutant rcd1 (PDE6B) an
Externí odkaz:
https://doaj.org/article/7374429b174746bfb853812f0123472b
Autor:
Ana Ripolles-Garcia, Gordon Ruthel, Gui-Shuang Ying, Yineng Chen, Nicolas Cuenca, Gustavo D. Aguirre, William A. Beltran
Publikováno v:
Frontiers in Neuroanatomy, Vol 15 (2021)
Purpose: To present a methodology for quantification of the canine retinal vasculature imaged by optical coherence tomography angiography (OCTA) and validate this approach by comparison with fluorescein angiography (FA) and confocal imaging of retina
Externí odkaz:
https://doaj.org/article/efb16067cdde4365b9b5e1592362bac8
Autor:
Sergei Nikonov, Natalia Dolgova, Raghavi Sudharsan, Ivan Tochitsky, Simone Iwabe, Jose-Manuel Guzman, Russell N. Van Gelder, Richard H. Kramer, Gustavo D. Aguirre, William A. Beltran
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2711 (2022)
Photopharmacological compounds such as azobenzene-based photoswitches have been shown to control the conductivity of ionic channels in a light-dependent manner and are considered a potential strategy to restore vision in patients with end-stage photo
Externí odkaz:
https://doaj.org/article/5919a5885bde42f29503b6d35b955585
Autor:
Leonardo Murgiano, Doreen Becker, Dina Torjman, Jessica K. Niggel, Ausra Milano, Cheryl Cullen, Rui Feng, Fan Wang, Vidhya Jagannathan, Sue Pearce-Kelling, Martin L. Katz, Tosso Leeb, Gustavo D. Aguirre
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 2, Pp 425-437 (2019)
Rod and cone photoreceptors are specialized retinal neurons that have a fundamental role in visual perception, capturing light and transducing it into a neuronal signal. Aberrant functioning of rod and/or cone photoreceptors can ultimately lead to pr
Externí odkaz:
https://doaj.org/article/b360b93802cd41f18edb473e292b5ad5
Autor:
Ritobrato Datta, Jongho Lee, Jeffrey Duda, Brian B. Avants, Charles H. Vite, Ben Tseng, James C. Gee, Gustavo D. Aguirre, Geoffrey K. Aguirre
Publikováno v:
PLoS ONE, Vol 8, Iss 12 (2013)
Externí odkaz:
https://doaj.org/article/916074a044e44ea8b4bfa83e747da80c
Autor:
András M. Komáromy D.M.V., Ph.D., Signe E. Varner, Eugene De Juan, Gregory M. Acland, Gustavo D. Aguirre
Publikováno v:
Cell Transplantation, Vol 15 (2006)
The use of a new subretinal injection device (RetinaJect™ Subretinal Cannula, SurModics, Inc., Eden Prairie, MN) to access the subretinal space in the canine model was evaluated. Subretinal injections were performed in 33 mongrel dogs between 2 and
Externí odkaz:
https://doaj.org/article/29b30cc31f1e4824aa8261ef45f02c32
Publikováno v:
BioTechniques, Vol 24, Iss 5, Pp 836-837 (1998)
Externí odkaz:
https://doaj.org/article/f66be92ca7bf4d08965a96d5d0a26840