Zobrazeno 1 - 10
of 259
pro vyhledávání: '"Gustavo Caetano-Anollés"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-21 (2023)
Abstract The structures and functions of proteins are embedded into the loop scaffolds of structural domains. Their origin and evolution remain mysterious. Here, we use a novel graph-theoretical approach to describe how modular and non-modular loop p
Externí odkaz:
https://doaj.org/article/211d9ce37a8d49bb918f751dce00ce01
Publikováno v:
Viruses, Vol 16, Iss 9, p 1358 (2024)
The COVID-19 pandemic saw the emergence of various Variants of Concern (VOCs) that took the world by storm, often replacing the ones that preceded them. The characteristic mutant constellations of these VOCs increased viral transmissibility and infec
Externí odkaz:
https://doaj.org/article/ac0befd65c5343f9ab2d081fedbdbb8d
Autor:
Gustavo Caetano-Anollés
Publikováno v:
Viruses, Vol 16, Iss 7, p 1061 (2024)
Virus taxonomy uses a Linnaean-like subsumption hierarchy to classify viruses into taxonomic units at species and higher rank levels. Virus species are considered monophyletic groups of mobile genetic elements (MGEs) often delimited by the phylogenet
Externí odkaz:
https://doaj.org/article/fa2e013b4d234fee8c18ab4a79ba9a37
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/4048e257a6ea4f778a88cf3801b0abb1
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Taxonomical classification has preceded evolutionary understanding. For that reason, taxonomy has become a battleground fueled by knowledge gaps, technical limitations, and a priorism. Here we assess the current state of the challenging field, focusi
Externí odkaz:
https://doaj.org/article/ea9a75791b854e51874e7de2a4e8870b
Publikováno v:
Biology, Vol 13, Iss 3, p 134 (2024)
The slow experimental acquisition of high-quality atomic structures of the rapidly changing proteins of the COVID-19 virus challenges vaccine and therapeutic drug development efforts. Fortunately, deep learning tools such as AlphaFold2 can quickly ge
Externí odkaz:
https://doaj.org/article/de607c63f1fe440eaae127da3ee9878f
Publikováno v:
Evolutionary Bioinformatics, Vol 19 (2023)
Many viral diseases exhibit seasonal behavior and can be affected by environmental stressors. Using time-series correlation charts extrapolated from worldwide data, we provide strong support for the seasonal development of COVID-19 regardless of the
Externí odkaz:
https://doaj.org/article/cd0e9e8f53e1452ca36c93f63e4ed3b5
Publikováno v:
F1000Research, Vol 12 (2023)
Background: Variants of concern (VOCs) have been replacing each other during the still rampant COVID-19 pandemic. As a result, SARS-CoV-2 populations have evolved increasingly intricate constellations of mutations that often enhance transmissibility,
Externí odkaz:
https://doaj.org/article/1bfb724563e4495f96a352a6912fb851
Autor:
Fengjie Sun, Gustavo Caetano-Anollés
Publikováno v:
Agronomy, Vol 13, Iss 10, p 2653 (2023)
It is well known and has been evidently indicated by numerous studies that the demand for food and energy supply has been rapidly increasing for many years worldwide [...]
Externí odkaz:
https://doaj.org/article/54cf41e02f38469891ad56457892a3c7
Autor:
Fizza Mughal, Gustavo Caetano-Anollés
Publikováno v:
Life, Vol 13, Iss 10, p 2055 (2023)
Intrinsic disorder accounts for the flexibility of protein loops, molecular building blocks that are largely responsible for the processes and molecular functions of the living world. While loops likely represent early structural forms that served as
Externí odkaz:
https://doaj.org/article/6564ae7b65d54e2bb2f1cca2c37edec1