Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Gustavo Barja"'
Publikováno v:
Experimental Gerontology, Vol 175, Iss , Pp 112162- (2023)
The evolutionary meaning and basic molecular mechanisms involved in the determination of longevity remain an unresolved problem. Currently, different theories are on offer in response to these biological traits and to explain the enormous range of lo
Externí odkaz:
https://doaj.org/article/dc179e82d1ac41c19296c35610168752
Publikováno v:
Experimental Gerontology, Vol 174, Iss , Pp 112134- (2023)
Mitochondria play a wide diversity of roles in cell physiology and have a key functional implication in cell bioenergetics and biology of free radicals. As the main cellular source of oxygen radicals, mitochondria have been postulated as the mediator
Externí odkaz:
https://doaj.org/article/0c34356a5e7a434cbc632de933fcf25d
Publikováno v:
Experimental Gerontology, Vol 174, Iss , Pp 112137- (2023)
The strong interest shown in the study of the causes of aging in recent decades has uncovered many mechanisms that could contribute to the rate of aging. These include mitochondrial ROS production, DNA modification and repair, lipid peroxidation-indu
Externí odkaz:
https://doaj.org/article/f34a83e395cb48acbe99eeef202d71b0
Autor:
Natalia Mota-Martorell, Mariona Jové, Rebeca Berdún, Èlia Òbis, Gustavo Barja, Reinald Pamplona
Publikováno v:
Biology, Vol 11, Iss 12, p 1821 (2022)
Methionine constitutes a central hub of intracellular metabolic adaptations leading to an extended longevity (maximum lifespan). The present study follows a comparative approach analyzing methionine and related metabolite and amino acid profiles usin
Externí odkaz:
https://doaj.org/article/35fcc3bc00b2422e86ac15d2eefe4882
Autor:
Natalia Mota-Martorell, Mariona Jove, Irene Pradas, Isabel Sanchez, José Gómez, Alba Naudi, Gustavo Barja, Reinald Pamplona
Publikováno v:
Redox Biology, Vol 34, Iss , Pp 101539- (2020)
Mitochondrial reactive oxygen species (ROS) production, specifically at complex I (Cx I), has been widely suggested to be one of the determinants of species longevity. The present study follows a comparative approach to analyse complex I in heart tis
Externí odkaz:
https://doaj.org/article/f8e4d88e746f46d3885516e7d0b8015d
Autor:
Reinald Pamplona, Manuel Portero-Otín, David Riba, Cristina Ruiz, Joan Prat, Maria Josep Bellmunt, Gustavo Barja
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 10, Pp 1989-1994 (1998)
The oxidative stress theory of aging predicts a low degree of fatty acid unsaturation in tissues of longevous animals, because membrane lipids increase their sensitivity to oxidative damage as a function of their unsaturation. Accordingly, the fatty
Externí odkaz:
https://doaj.org/article/895e58443db04f6a878cfdda15cea143
Autor:
Reinald Pamplona, Gustavo Barja
Publikováno v:
Aging (Albany NY)
Repositorio Abierto de la UdL
Universitad de Lleida
Repositorio Abierto de la UdL
Universitad de Lleida
Many specific cell afferent signalling pathways like the insulin/IGF-1-like or the mechanistic target of rapamycin (mTOR) pathways contribute to modify longevity by modulating the nuclear aging program (AP) [1,2] target gene expression, which modulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c7ba60a63a37a72194da3d554761f3
https://pubmed.ncbi.nlm.nih.gov/34057907
https://pubmed.ncbi.nlm.nih.gov/34057907
Autor:
Patón, Daniel, Juarranz, Angeles, Sequeros, Encarnación, Pérez-Campo, Rosa, López-Torres, Mónica, de Quiroga, Gustavo Barja
Publikováno v:
Journal of Herpetology, 1991 Dec 01. 25(4), 389-394.
Externí odkaz:
https://www.jstor.org/stable/1564759
Autor:
Gustavo Barja
Publikováno v:
E-Prints Complutense. Archivo Institucional de la UCM
instname
Aging (Albany NY)
instname
Aging (Albany NY)
Positive correlation between genomic DNA repair and longevity has been classically described (reviewed in [1]). However, this corresponded to repair of exogenous DNA damage estimated as unscheduled DNA synthesis in fibroblasts (mitotic cells) after i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc9f6412323af7502668668410435c8
https://eprints.ucm.es/id/eprint/72351/1/Barja-DGFM-Higher-DNA.pdf
https://eprints.ucm.es/id/eprint/72351/1/Barja-DGFM-Higher-DNA.pdf
Publikováno v:
The FEBS journalReferences. 288(23)
Complex I, a component of the electron transport chain, plays a central functional role in cell bioenergetics and the biology of free radicals. The structural and functional N module of complex I is one of the main sites of the generation of free rad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::442f58ac5237ba520bf4bde55b30ac18
https://pubmed.ncbi.nlm.nih.gov/33455045
https://pubmed.ncbi.nlm.nih.gov/33455045