Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Gustavo, Arrizabalaga"'
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTApicomplexan parasites, including Toxoplasma gondii, encode many plant-like proteins, which play significant roles and present attractive targets for drug development. In this study, we have characterized the plant-like protein phosphatase PP
Externí odkaz:
https://doaj.org/article/66a0e1eb7c414b0392dbdb51f42f7874
Autor:
Vanessa Severo, Rodolpho Souza, Francisca Vitorino, Julia Cunha, Andréa Ávila, Gustavo Arrizabalaga, Sheila Nardelli
Publikováno v:
mSphere, Vol 7, Iss 6 (2022)
ABSTRACT Chromatin dynamics can regulate all DNA-dependent processes. Access to DNA within chromatin is orchestrated mainly by histones and their posttranslational modifications (PTMs). Like other eukaryotes, the apicomplexan parasite Toxoplasma gond
Externí odkaz:
https://doaj.org/article/f3d333709fa749bd8f85941b9d1b64c0
Autor:
Stephanie D Nofal, Caia Dominicus, Malgorzata Broncel, Nicholas J Katris, Helen R Flynn, Gustavo Arrizabalaga, Cyrille Y Botté, Brandon M Invergo, Moritz Treeck
Publikováno v:
PLoS Pathogens, Vol 18, Iss 10, p e1010901 (2022)
Fundamental processes that govern the lytic cycle of the intracellular parasite Toxoplasma gondii are regulated by several signalling pathways. However, how these pathways are connected remains largely unknown. Here, we compare the phospho-signalling
Externí odkaz:
https://doaj.org/article/f1bcfcff899b4410afe264cbf598c595
Publikováno v:
mSphere, Vol 7, Iss 3 (2022)
ABSTRACT The pathogenesis of Toxoplasma gondii is mainly due to tissue damage caused by the repeating lytic cycles of the parasite. Many proteins localized to the pellicle of the parasite, particularly kinases, have been identified as critical regula
Externí odkaz:
https://doaj.org/article/088c045ec3e04f4a86bba2431e80aa19
Publikováno v:
Cells, Vol 11, Iss 10, p 1709 (2022)
The propagation of the obligate intracellular parasite Toxoplasma gondii is tightly regulated by calcium signaling. However, the mechanisms by which calcium homeostasis and fluxes are regulated in this human pathogen are not fully understood. To iden
Externí odkaz:
https://doaj.org/article/2bf30ade88b044cbae090ecb647d68bd
Publikováno v:
mSphere, Vol 5, Iss 1 (2020)
ABSTRACT During host cell invasion, the eukaryotic pathogen Toxoplasma gondii forms a parasitophorous vacuole to safely reside within the cell, while it is partitioned from host cell defense mechanisms. From within this safe niche, parasites sabotage
Externí odkaz:
https://doaj.org/article/0ae5a106e4684bbc8fd846b7dd46a6c6
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT Toxoplasma gondii’s single mitochondrion is very dynamic and undergoes morphological changes throughout the parasite’s life cycle. During parasite division, the mitochondrion elongates, enters the daughter cells just prior to cytokinesis
Externí odkaz:
https://doaj.org/article/f05fe802f04b4d01b4d577427b32ddc7
Autor:
Gustavo Arrizabalaga
Publikováno v:
mSphere, Vol 4, Iss 4 (2019)
ABSTRACT The opportunistic pathogen Toxoplasma gondii is highly adept at manipulating host cell functions. While inside a host cell, Toxoplasma divides within a parasitophorous vacuole from which it secretes numerous effector proteins from its dense
Externí odkaz:
https://doaj.org/article/22d992b21b9740819ea0b6533d97f199
Publikováno v:
mBio, Vol 9, Iss 2 (2018)
ABSTRACT In the protozoan parasite Toxoplasma gondii, protein kinases have been shown to play key roles in regulating parasite motility, invasion, replication, egress, and survival within the host. The tyrosine kinase-like (TKL) family of proteins ar
Externí odkaz:
https://doaj.org/article/eb07f9187fe0497192722b5ff1dc6c17
Autor:
Rodolpho Ornitz Oliveira Souza, Kylie N. Jacobs, Peter S. Back, Peter J. Bradley, Gustavo Arrizabalaga
Publikováno v:
Journal of Cell Science. 135
The single mitochondrion of Toxoplasma gondii is highly dynamic, being predominantly in a peripherally distributed lasso-shape in intracellular parasites and collapsed in extracellular parasites. The peripheral positioning of the mitochondrion is ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac5e46eebe190dad4f206c3f4983de95
https://doi.org/10.1242/jcs.260083
https://doi.org/10.1242/jcs.260083