Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Gustav Holmgren"'
Publikováno v:
Journal of Intensive Care, Vol 7, Iss 1, Pp 1-8 (2019)
Abstract Purpose We investigated if early intensive care unit (ICU) scoring with the Simplified Acute Physiology Score (SAPS 3) could be improved using artificial neural networks (ANNs). Methods All first-time adult intensive care admissions in Swede
Externí odkaz:
https://doaj.org/article/cc512823d526480a8a7c1ed2948936d7
Autor:
Gustav Holmgren, Benjamin Ulfenborg, Annika Asplund, Karin Toet, Christian X Andersson, Ann Hammarstedt, Roeland Hanemaaijer, Barbara Küppers-Munther, Jane Synnergren
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 2, p 469 (2020)
There is a strong anticipated future for human induced pluripotent stem cell-derived hepatocytes (hiPS-HEP), but so far, their use has been limited due to insufficient functionality. We investigated the potential of hiPS-HEP as an in vitro model for
Externí odkaz:
https://doaj.org/article/bde51733d8e84560b44f2262f7cd88d3
Autor:
Arvind Pradip, Daniella Steel, Susanna Jacobsson, Gustav Holmgren, Magnus Ingelman-Sundberg, Peter Sartipy, Petter Björquist, Inger Johansson, Josefina Edsbagge
Publikováno v:
Stem Cells International, Vol 2016 (2016)
Hepatotoxicity is one of the most cited reasons for withdrawal of approved drugs from the market. The use of nonclinically relevant in vitro and in vivo testing systems contributes to the high attrition rates. Recent advances in differentiating human
Externí odkaz:
https://doaj.org/article/8b203484bced439b8882919f567af0b1
Autor:
Klas Österberg, Yalda Bogestål, Lachmi Jenndahl, Tobias Gustafsson-Hedberg, Jane Synnergren, Gustav Holmgren, Eva Bom, Sarunas Petronis, Annika Krona, Jonna S. Eriksson, Jennifer Rosendahl, Veronica Crisostomo, Francisco M. Sanchez-Margallo, Claudia Baez-Diaz, Raimund Strehl, Joakim Håkansson
Tissue engineering is a promising methodology to produce advanced therapy medicinal products (ATMPs). We have developed personalized tissue engineered veins (P-TEV) as an alternative to autologous or synthetic vascular grafts utilized in reconstructi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbb94cb1c371ba35f865b80f9f928e1
http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-22436
http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-22436
Publikováno v:
Journal of Intensive Care, Vol 7, Iss 1, Pp 1-8 (2019)
Journal of Intensive Care
Journal of Intensive Care
Purpose We investigated if early intensive care unit (ICU) scoring with the Simplified Acute Physiology Score (SAPS 3) could be improved using artificial neural networks (ANNs). Methods All first-time adult intensive care admissions in Sweden during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f735f65e0e86f61ea6c4e3a416d0719
http://link.springer.com/article/10.1186/s40560-019-0393-1
http://link.springer.com/article/10.1186/s40560-019-0393-1
Autor:
Annika Asplund, Benjamin Ulfenborg, Gustav Holmgren, Christian X. Andersson, Barbara Küppers-Munther, Jane Synnergren, Ann Hammarstedt, Roeland Hanemaaijer, Karin Toet
There is a strong anticipated future for human pluripotent stem cell-derived hepatocytes (hiPS-HEP), but so far their use has been limited due to insufficient functionality. We investigated the potential of hiPS-HEP as an in vitro model for metabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d96fc9faf953661f2ae0f3b834c06e
https://doi.org/10.20944/preprints201911.0162.v1
https://doi.org/10.20944/preprints201911.0162.v1
Publikováno v:
Toxicology in Vitro. 34:26-34
Anthracyclines, such as doxorubicin, are well-established, highly efficient anti-neoplastic drugs used for treatment of a variety of cancers, including solid tumors, leukemia, lymphomas, and breast cancer. The successful use of doxorubicin has, howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87923635d7976c8bf707a5fa46baa308
https://doi.org/10.1016/j.tiv.2016.03.009
https://doi.org/10.1016/j.tiv.2016.03.009
Anthracyclines, such as doxorubicin, are highly efficient chemotherapeutic agents against a variety of cancers. However, anthracyclines are also among the most cardiotoxic therapeutic drugs presently on the market. Chemotherapeutic-induced cardiomyop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f8173d5f852d460ffa474456ceaec6
http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-14745
http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-14745
Autor:
Xianmin Zeng, Peter Sartipy, Nidal Ghosheh, Gustav Holmgren, X Jane Synnergren, Yalda Bogestål
Publikováno v:
Physiological Genomics. 47:232-239
Reference genes, often referred to as housekeeping genes (HKGs), are frequently used to normalize gene expression data based on the assumption that they are expressed at a constant level in the cells. However, several studies have shown that there ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3333a991ca5c26ad4db91014d1c831a8
https://doi.org/10.1152/physiolgenomics.00130.2014
https://doi.org/10.1152/physiolgenomics.00130.2014
Autor:
Lindsay Davidson, Marie Rehnström, Barbara Küppers-Munther, Susanna Jacobsson, Tommy B. Andersson, Maria Ulvestad, Annika Asplund, Petter Björquist, Gustav Holmgren, Josefina Edsbagge, Pär Nordell, Gabriella Brolén
Publikováno v:
Biochemical Pharmacology. 86:691-702
Human embryonic and induced pluripotent stem cell-derived hepatocytes (hESC-Hep and hiPSC-Hep) have the potential to provide relevant human in vitro model systems for toxicity testing and drug discovery studies. In this study, the expression and func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca3f8f050667cf5de55ebc6a60ef58dc
https://doi.org/10.1016/j.bcp.2013.06.029
https://doi.org/10.1016/j.bcp.2013.06.029