Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Gustav Boije Af Gennäs"'
Autor:
Mikael Jumppanen, Sini M. Kinnunen, Matej Zore, Mika J. Välimäki, Virpi Talman, Gustav Boije af Gennäs, Heikki J. Ruskoaho, Jari Yli-Kauhaluoma
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Heart failure is a serious medical condition with a poor prognosis. Current treatments can only help manage the symptoms and slow the progression of heart failure. However, there is currently no cure to prevent and reverse cardiac remodeling
Externí odkaz:
https://doaj.org/article/2029b729860d4650ad7fb8a5f2680938
Autor:
Gianmario Scotti, Sofia M.E. Nilsson, Ville-Pekka Matilainen, Markus Haapala, Gustav Boije af Gennäs, Jari Yli-Kauhaluoma, Antti Salminen, Tapio Kotiaho
Publikováno v:
Heliyon, Vol 5, Iss 7, Pp e02002- (2019)
A simple flow chemistry microreactor with an electrospray ionization tip for real time mass spectrometric reaction monitoring is introduced. The microreactor was fabricated by a laser-based additive manufacturing technique from acid-resistant stainle
Externí odkaz:
https://doaj.org/article/f945b08b2289453e8914070fbb21164a
Autor:
Riccardo Provenzani, Ilari Tarvainen, Giulia Brandoli, Antti Lempinen, Sanna Artes, Ainoleena Turku, Maria Helena Jäntti, Virpi Talman, Jari Yli-Kauhaluoma, Raimo K Tuominen, Gustav Boije Af Gennäs
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195668 (2018)
Protein kinase C (PKC) isoforms play a pivotal role in the regulation of numerous cellular functions, making them extensively studied and highly attractive drug targets. Utilizing the crystal structure of the PKCδ C1B domain, we have developed hydro
Externí odkaz:
https://doaj.org/article/011c3ac1fd414b3695e15b73be2e16e1
Autor:
Ainoleena Turku, Maiju K Rinne, Gustav Boije Af Gennäs, Henri Xhaard, Dan Lindholm, Jyrki P Kukkonen
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178526 (2017)
Two promising lead structures of small molecular orexin receptor agonist have been reported, but without detailed analyses of the pharmacological properties. One of them, 1-(3,4-dichlorophenyl)-2-[2-imino-3-(4-methylbenzyl)-2,3-dihydro-1H-benzo[d]imi
Externí odkaz:
https://doaj.org/article/d9d6d479432e4f74a00380e93b4b81dc
Autor:
Nathalie Acevedo, Annika Sääf, Cilla Söderhäll, Erik Melén, Jami Mandelin, Christina Orsmark Pietras, Sini Ezer, Piia Karisola, Johanna Vendelin, Gustav Boije af Gennäs, Jari Yli-Kauhaluoma, Harri Alenius, Erika von Mutius, Gert Doekes, Charlotte Braun-Fahrländer, Josef Riedler, Marianne van Hage, Mauro D'Amato, Annika Scheynius, Göran Pershagen, Juha Kere, Ville Pulkkinen
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60111 (2013)
Retinoid acid receptor-related Orphan Receptor Alpha (RORA) was recently identified as a susceptibility gene for asthma in a genome-wide association study. To investigate the impact of RORA on asthma susceptibility, we performed a genetic association
Externí odkaz:
https://doaj.org/article/05e487baa79545f591a6284a69b73392
Publikováno v:
PLoS ONE, Vol 6, Iss 6 (2011)
Externí odkaz:
https://doaj.org/article/e41a481fc557426d9181fc2460a2043a
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20053 (2011)
Diacylglycerol (DAG)-mediated signaling pathways, such as those mediated by protein kinase C (PKC), are central in regulating cell proliferation and apoptosis. DAG-responsive C1 domains are therefore considered attractive drug targets. Our group has
Externí odkaz:
https://doaj.org/article/e3685c5f959d4ba7b7a7922827e33017
Autor:
Jianing Liu, Loic Dreano, Keni Vidilaseris, Gustav Boije af Gennäs, Jari Yli-Kauhaluoma, Arthur Lasbleiz, Henri Xhaard, Niklas G. Johansson, Alexandros Kiriazis, Orquidea Marilia de Castro Ribeiro, Adrian Goldman, Ayman Khattab, Seppo Meri
Publikováno v:
Chemmedchem
Inhibition of membrane‐bound pyrophosphatase (mPPase) with small molecules offer a new approach in the fight against pathogenic protozoan parasites. mPPases are absent in humans, but essential for many protists as they couple pyrophosphate hydrolys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e278a2a6f27c85d051eefc4ff4c9fad
https://doi.org/10.1002/cmdc.202100392
https://doi.org/10.1002/cmdc.202100392
Autor:
Niklas G. Johansson, Evgeni Grazhdankin, Loic Dreano, Ayman Khattab, Colin W. G. Fishwick, Ainoleena Turku, Alexandros Kiriazis, Jari Yli-Kauhaluoma, Henri Xhaard, Daniel Ayuso Pérez, Adrian Goldman, Gustav Boije af Gennäs, Aaron Wilkinson, Yuezhou Zhang, Keni Vidilaseris, Matti Tamminen, Seppo Meri
Publikováno v:
ACS Medicinal Chemistry Letters
Membrane-bound pyrophosphatases (mPPases) regulate energy homeostasis in pathogenic protozoan parasites and lack human homologues, which makes them promising targets in e.g. malaria. Yet only few nonphosphorus inhibitors have been reported so far. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfaec4e239aee10ccef50dda17fbbbe8
https://doi.org/10.1021/acsmedchemlett.9b00537
https://doi.org/10.1021/acsmedchemlett.9b00537
Autor:
Heikki Ruskoaho, Mika J. Välimäki, Samuli Auno, Jari Yli-Kauhaluoma, Ingo B. Aumüller, Virpi Talman, Henri Xhaard, Gustav Boije af Gennäs, Sini Kinnunen, Tanja Bruun, Mikael Jumppanen
Publikováno v:
Journal of Medicinal Chemistry
Transcription factors GATA4 and NKX2-5 directly interact and synergistically activate several cardiac genes and stretch-induced cardiomyocyte hypertrophy. Previously, we identified phenylisoxazole carboxamide 1 as a hit compound, which inhibited the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed87878294538799b8cdc84144570443
http://europepmc.org/articles/PMC7076710
http://europepmc.org/articles/PMC7076710