Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Gustaf Wigerblad"'
Autor:
Katy A. Lloyd, Gustaf Wigerblad, Peter Sahlström, Manasa G. Garimella, Karine Chemin, Johanna Steen, Philip J. Titcombe, Bianka Marklein, Diana Zhou, Ragnhild Stålesen, Elena Ossipova, Christina Lundqvist, Olov Ekwall, Johan Rönnelid, Daniel L. Mueller, Mikael C. I. Karlsson, Mariana J. Kaplan, Karl Skriner, Lars Klareskog, Fredrik Wermeling, Vivianne Malmström, Caroline Grönwall
Publikováno v:
Frontiers in Immunology, Vol 9 (2019)
Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) target a wide range of modified proteins. Citrullination occurs during physiological processes such as apoptosis, yet little is known about the interaction of ACPA
Externí odkaz:
https://doaj.org/article/d70eb37c09dc4ed0b944aa6b0515afd8
Autor:
Sally Abdelmoaty, Gustaf Wigerblad, Duygu B Bas, Simone Codeluppi, Teresa Fernandez-Zafra, El-Sayed El-Awady, Yasser Moustafa, Alaa El-Din S Abdelhamid, Ernst Brodin, Camilla I Svensson
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75543 (2013)
Lipoxins and resolvins have anti-inflammatory and pro-resolving actions and accumulating evidence indicates that these lipid mediators also attenuate pain-like behavior in a number of experimental models of inflammation and tissue injury-induced pain
Externí odkaz:
https://doaj.org/article/f8a47359912d4b3e8048065faade50c9
Autor:
Gustaf Wigerblad, Seth A. Warner, Marcos J. Ramos-Benitez, Lela Kardava, Xin Tian, Rui Miao, Robert Reger, Mala Chakraborty, Susan Wong, Yogendra Kanthi, Anthony F. Suffredini, Stefania Dell’Orso, Stephen Brooks, Christopher King, Oksana Shlobin, Steven D. Nathan, Jonathan Cohen, Susan Moir, Richard W. Childs, Mariana J. Kaplan, Daniel S. Chertow, Jeffrey R. Strich
Publikováno v:
Science advances, vol 9, iss 1
Spleen tyrosine kinase (SYK) is a previously unidentified therapeutic target that inhibits neutrophil and macrophage activation in coronavirus disease 2019 (COVID-19). Fostamatinib, a SYK inhibitor, was studied in a phase 2 placebo-controlled randomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b029f0b5bfbeacbd65b2880c83798186
https://pubmed.ncbi.nlm.nih.gov/36598976
https://pubmed.ncbi.nlm.nih.gov/36598976
Autor:
Gustaf Wigerblad, Mariana J. Kaplan
Publikováno v:
Nature reviews. Immunology.
Systemic autoimmune diseases are characterized by the failure of the immune system to differentiate self from non-self. These conditions are associated with significant morbidity and mortality, and they can affect many organs and systems, having sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd05cf10b1fbe120327899f4fdc102dd
https://pubmed.ncbi.nlm.nih.gov/36257987
https://pubmed.ncbi.nlm.nih.gov/36257987
Autor:
Wanxia L. Tsai, Robert A. Colbert, Marcus Y Chen, Arlene Sirajuddin, Ryan S. Laird, Peter C. Grayson, Patrycja Hoffmann, Sinisa Savic, Marcela A. Ferrada, Emma M. Groarke, Kristina V. Wells, Massimo Gadina, Bhavisha A Patel, Mariana J. Kaplan, Keith A. Sikora, Emily Rose, Lorena Wilson, Daniel L. Kastner, Gustaf Wigerblad, Zuoming Deng, Amanda K. Ombrello, Oskar Schnappauf, Emily Rominger, Kaitlin A. Quinn, Daniela Ospina Cardona, Jeff Kim, Ivona Aksentijevich, Neal S. Young, David B. Beck, Wendy Goodspeed, Clint T. Allen, Mimi T. Le, Katherine R. Calvo, Yiming Luo, Anne Jones
Publikováno v:
Arthritis & Rheumatology. 73:1886-1895
Objective Somatic mutations in UBA1 cause a newly defined syndrome known as VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic syndrome). More than 50% of patients currently identified as having VEXAS met diagnostic criteria for relapsin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37447f01621cbbbfbba7098afa3da792
https://doi.org/10.1002/art.41743
https://doi.org/10.1002/art.41743
Autor:
Sarthak Gupta, Amanda K. Ombrello, Emily Rominger, Megan Trick, Karyl S. Barron, Ryan S. Laird, Sinisa Savic, Shuichiro Nakabo, Daniela Ospina Cardona, Ivona Aksentijevich, Carmelo Carmona-Rivera, Gustaf Wigerblad, Mariana J. Kaplan, Emma M. Groarke, Laura W. Dillon, Chyi-Chia Richard Lee, Kalpana Manthiram, Kristina V. Wells, Nicholas Balanda, Zhijie Wu, Helen J. Lachmann, Daniel L. Kastner, Fernanda Gutierrez-Rodrigues, Achim Werner, Michele Nehrebecky, Lisha Xu, Alina Dulau-Florea, Wanxia L. Tsai, Bhavisha A Patel, Stefania Dell'Orso, Weixin Wang, Anthony J. Asmar, Danica Novacic, Katherine R. Calvo, David B. Beck, Robert A. Colbert, Massimo Gadina, William A. Gahl, Wendy Goodspeed, Natalie Deuitch, Dorota Rowczenio, Peter C. Grayson, Daron L. Ross, Sofia Rosenzweig, Anne Jones, Christopher S. Hourigan, James C. Mullikin, Stephen R. Brooks, Jason C. Collins, Wuhong Pei, May Christine V. Malicdan, Neal S. Young, Shawn M. Burgess, Keith A. Sikora, Mones Abu-Asab, Kyle Retterer, Patrycja Hoffmann, Hirotsugu Oda, Marcela A. Ferrada, Zuoming Deng, Benjamin D. Solomon, Jae Jin Chae
Publikováno v:
New England Journal of Medicine. 383:2628-2638
Background Adult-onset inflammatory syndromes often manifest with overlapping clinical features. Variants in ubiquitin-related genes, previously implicated in autoinflammatory disease, may...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99ad8cf39fc35fb40359e43ad0eff90c
https://doi.org/10.1056/nejmoa2026834
https://doi.org/10.1056/nejmoa2026834
Autor:
Jie Su, Emerson Krock, Swapnali Barde, Ada Delaney, Johnny Ribeiro, Jungo Kato, Nilesh Agalave, Gustaf Wigerblad, Rosalia Matteo, Roger Sabbadini, Anna Josephson, Jerold Chun, Kim Kultima, Olivier Peyruchaud, Tomas Hökfelt, Camilla I. Svensson
Publikováno v:
Brain, Behavior, and Immunity
Brain, Behavior, and Immunity, 2022, 101, pp.214-230. ⟨10.1016/j.bbi.2022.01.003⟩
Brain, Behavior, and Immunity, 2022, 101, pp.214-230. ⟨10.1016/j.bbi.2022.01.003⟩
International audience; Inflammatory and neuropathic-like components underlie rheumatoid arthritis (RA)-associated pain, and lysophosphatidic acid (LPA) is linked to both joint inflammation in RA patients and to neuropathic pain. Thus, we investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b29dc2d42c562e763464fb315e36c2d0
https://www.hal.inserm.fr/inserm-03847767
https://www.hal.inserm.fr/inserm-03847767
Autor:
David B, Beck, Marcela A, Ferrada, Keith A, Sikora, Amanda K, Ombrello, Jason C, Collins, Wuhong, Pei, Nicholas, Balanda, Daron L, Ross, Daniela, Ospina Cardona, Zhijie, Wu, Bhavisha, Patel, Kalpana, Manthiram, Emma M, Groarke, Fernanda, Gutierrez-Rodrigues, Patrycja, Hoffmann, Sofia, Rosenzweig, Shuichiro, Nakabo, Laura W, Dillon, Christopher S, Hourigan, Wanxia L, Tsai, Sarthak, Gupta, Carmelo, Carmona-Rivera, Anthony J, Asmar, Lisha, Xu, Hirotsugu, Oda, Wendy, Goodspeed, Karyl S, Barron, Michele, Nehrebecky, Anne, Jones, Ryan S, Laird, Natalie, Deuitch, Dorota, Rowczenio, Emily, Rominger, Kristina V, Wells, Chyi-Chia R, Lee, Weixin, Wang, Megan, Trick, James, Mullikin, Gustaf, Wigerblad, Stephen, Brooks, Stefania, Dell'Orso, Zuoming, Deng, Jae J, Chae, Alina, Dulau-Florea, May C V, Malicdan, Danica, Novacic, Robert A, Colbert, Mariana J, Kaplan, Massimo, Gadina, Sinisa, Savic, Helen J, Lachmann, Mones, Abu-Asab, Benjamin D, Solomon, Kyle, Retterer, William A, Gahl, Shawn M, Burgess, Ivona, Aksentijevich, Neal S, Young, Katherine R, Calvo, Achim, Werner, Daniel L, Kastner, Peter C, Grayson
Publikováno v:
Arthritis Rheumatol
Adult-onset inflammatory syndromes often manifest with overlapping clinical features. Variants in ubiquitin-related genes, previously implicated in autoinflammatory disease, may define new disorders.We analyzed peripheral-blood exome sequence data in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8619cd7f680f820c748afb4ee52d1640
https://pubmed.ncbi.nlm.nih.gov/34463053
https://pubmed.ncbi.nlm.nih.gov/34463053
Autor:
Katherine N Howe, Liam J. O’Neil, Hege Lynum Pedersen, Mariana J. Kaplan, Sarfaraz Hasni, Diana Chan, Paul Kruszka, Luz P. Blanco, Maximilian Muenke, Sarthak Gupta, Hong-Wei Sun, Shuichiro Nakabo, Xinghao Wang, Faiza Naz, Gustaf Wigerblad, Ashley Buscetta, Rishi R. Goel, Pragnesh Mistry, Kan Jiang, Luis M. Franco, Caeden Dempsey, Pamela A. Frischmeyer-Guerrerio, Manasi Gadkari, Carmelo Carmona-Rivera, Stefania Dell'Orso
Publikováno v:
Proc Natl Acad Sci U S A
Differences between female and male immunity may contribute to variations in response to infections and predisposition to autoimmunity. We previously reported that neutrophils from reproductive-age males are more immature and less activated than thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d143bb08a6d166cd7a9fecb5504b08fa
https://pubmed.ncbi.nlm.nih.gov/32601182
https://pubmed.ncbi.nlm.nih.gov/32601182
Autor:
Rishi R. Goel, Shuichiro Nakabo, Zu-Xi Yu, Maria I. Morasso, Sarthak Gupta, Xinghao Wang, Gustaf Wigerblad, Mariana J. Kaplan, Carmelo Carmona-Rivera, Sergei V. Kotenko, Kowser Hasneen, Jeffrey B. Kopp, Liam J. O’Neil, Luz P. Blanco
Publikováno v:
Proc Natl Acad Sci U S A
Type III IFN lambdas (IFN-λ) have recently been described as important mediators of immune responses at barrier surfaces. However, their role in autoimmune diseases such as systemic lupus erythematosus (SLE), a condition characterized by aberrant ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728798f9467c34ab183a33975b3a8c3a
https://pubmed.ncbi.nlm.nih.gov/32094169
https://pubmed.ncbi.nlm.nih.gov/32094169