Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Gusheng Wu"'
Publikováno v:
Applied Sciences, Vol 14, Iss 18, p 8330 (2024)
The prediction of land subsidence is of significant value for the early warning and prevention of geological disasters. Although numerous land subsidence prediction methods are currently available, two obstacles still exist: (i) spatio-temporal heter
Externí odkaz:
https://doaj.org/article/5fa8de85a2df4838b4eb44f1bfb67ec9
Publikováno v:
Biomedicines, Vol 11, Iss 1, p 209 (2023)
The purpose of this study was to determine whether the age-related decline in a-series gangliosides (especially GM1), shown to be a factor in the brain-related etiology of Parkinson’s disease (PD), also pertains to the peripheral nervous system (PN
Externí odkaz:
https://doaj.org/article/1d05e760741742b1a765e26a3c6640f7
Autor:
Mariko Saito, Gusheng Wu, Maria Hui, Kurt Masiello, Kostantin Dobrenis, Robert W. Ledeen, Mitsuo Saito
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 8, Pp 1434-1448 (2015)
Our previous studies have shown accumulation of GM2 ganglioside during ethanol-induced neurodegeneration in the developing brain, and GM2 elevation has also been reported in other brain injuries and neurodegenerative diseases. Using GM2/GD2 synthase
Externí odkaz:
https://doaj.org/article/547db53b676e481eb8266ffec9b5cbf4
Autor:
Robert W. Ledeen, Gusheng Wu
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 6, Pp 1176-1186 (2008)
Sphingolipids are most prominently expressed in the plasma membrane, but recent studies have pointed to important signaling and regulatory roles in the nucleus. The most abundant nuclear sphingolipid is sphingomyelin (SM), which occurs in the nuclear
Externí odkaz:
https://doaj.org/article/6b289cb86ff341bcaeb02ca38fe000b0
Autor:
Robert W. Ledeen, Gusheng Wu
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 1, Pp 1-8 (2004)
Lipids have long been recognized as quantitatively minor components of the nucleus, where they were initially thought to have little functional importance; but they now command growing interest, with recognition of their diverse signaling and modulat
Externí odkaz:
https://doaj.org/article/32de5be8d0094eb39c55291b48747537
Publikováno v:
Glycoconjugate Journal. 39:75-82
Following our initial reports on subnormal levels of GM1 in the substantia nigra and occipital cortex of Parkinson’s disease (PD) patients, we have examined additional tissues from such patients and found these are also deficient in the ganglioside
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9ca29d723a1aa4042924af22a10258
https://doi.org/10.1007/s10719-021-10025-9
https://doi.org/10.1007/s10719-021-10025-9
Autor:
Elena Chiricozzi, Margherita Maggioni, Maria Fazzari, Erika Di Biase, Pamela Fato, Gianluca Verlengia, Gusheng Wu, Diego Yuri Pomè, Simona Prioni, Giulia Lunghi, Laura Mauri, Stefano Cattaneo, Robert Assini, Sandro Sonnino, Robert W. Ledeen, Nicoletta Loberto, Samar K. Alselehdar, Manuela Valsecchi, Maria Grazia Ciampa
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Given the recent in vitro discovery that the free soluble oligosaccharide of GM1 is the bioactive portion of GM1 for neurotrophic functions, we investigated its therapeutic potential in the B4galnt1+/− mice, a model of sporadic Parkinson’s diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb574fc4f6a4bc857fd588d7d5193af4
http://link.springer.com/article/10.1038/s41598-019-55885-2
http://link.springer.com/article/10.1038/s41598-019-55885-2
Publikováno v:
Experimental neurology. 329
Parkinson's disease (PD) is a major neurodegenerative disorder characterized by a variety of non-motor symptoms in addition to the well-recognized motor dysfunctions that have commanded primary interest. We previously described a new PD mouse model b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5991f9afec5082e5e24e3bb65bb4cea8
https://pubmed.ncbi.nlm.nih.gov/32165255
https://pubmed.ncbi.nlm.nih.gov/32165255
Publikováno v:
Journal of Neurochemistry. 136:550-563
Axon-like neuritogenesis in neuroblastoma (NG108-15) cells and primary cerebellar granular neurons is furthered by the presence of ganglioside GM1. We describe here that galectin-1 (Gal-1), a homobivalent endogenous lectin, is an effector by cross-li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d27d2839520861b11dba1f77ac72abb
https://doi.org/10.1111/jnc.13418
https://doi.org/10.1111/jnc.13418
Autor:
Robert, Ledeen, Gusheng, Wu
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1804
This review begins by attempting to recount some of the pioneering discoveries that first identified the presence of gangliosides in the nervous system, their structures and topography. This is presented as prelude to the current emphasis on physiolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cefa448e4bdab611f177cddbd377ddc3
https://pubmed.ncbi.nlm.nih.gov/29926403
https://pubmed.ncbi.nlm.nih.gov/29926403