Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Gus O. Nwosu"'
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-11 (2024)
Abstract Acute myeloid leukaemia (AML) is a highly aggressive and devastating malignancy of the bone marrow and blood. For decades, intensive chemotherapy has been the frontline treatment for AML but has yielded only poor patient outcomes as exemplif
Externí odkaz:
https://doaj.org/article/dc1c39a7779f4dfb9e69f8fe8eaeab86
Publikováno v:
Experimental Hematology & Oncology, Vol 11, Iss 1, Pp 1-15 (2022)
Abstract While numerous targeted therapies have been recently adopted to improve the treatment of hematologic malignancies, acquired or intrinsic resistance poses a significant obstacle to their efficacy. Thus, there is increasing need to identify no
Externí odkaz:
https://doaj.org/article/14caca18f57e45f690dcca7bbe4e8ffa
Autor:
Alexander C. Lewis, Victoria S. Pope, Melinda N. Tea, Manjun Li, Gus O. Nwosu, Thao M. Nguyen, Craig T. Wallington-Beddoe, Paul A. B. Moretti, Dovile Anderson, Darren J. Creek, Maurizio Costabile, Saira R. Ali, Chloe A. L. Thompson-Peach, B. Kate Dredge, Andrew G. Bert, Gregory J. Goodall, Paul G. Ekert, Anna L. Brown, Richard D’Andrea, Nirmal Robinson, Melissa R. Pitman, Daniel Thomas, David M. Ross, Briony L. Gliddon, Jason A. Powell, Stuart M. Pitson
Inducing cell death by the sphingolipid ceramide is a potential anticancer strategy, but the underlying mechanisms remain poorly defined. In this study, triggering an accumulation of ceramide in acute myeloid leukemia (AML) cells by inhibition of sph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed8fbe2daf653ebbee791ab6b83276b
https://hdl.handle.net/11541.2/31406
https://hdl.handle.net/11541.2/31406