GLP-1 agonists protect pancreatic {beta}-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB

Autor: Cunha, Da, Ladrière, L, Ortis, F, IGOILLO ESTEVE, M, Gurzov, En, Lupi, R, Marchetti, Piero, Eizirik, Dl, Cnop, M.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3728::4c6129fa15fd8e19dabc0adf99cd301f
http://hdl.handle.net/11568/131655

Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis.

Autor: Cunha DA, Igoillo-Esteve M, Gurzov EN, Germano CM, Naamane N, Marhfour I, Fukaya M, Vanderwinden JM, Gysemans C, Mathieu C, Marselli L, Marchetti P, Harding HP, Ron D, Eizirik DL, Cnop M, Cunha, Daniel A, Igoillo-Esteve, Mariana, Gurzov, Esteban N, Germano, Carla M

Publikováno v: Diabetes; Nov2012, Vol. 61 Issue 11, p2763-2775, 13p

Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death.

Autor: Arif S, Moore F, Marks K, Bouckenooghe T, Dayan CM, Planas R, Vives-Pi M, Powrie J, Tree T, Marchetti P, Huang GC, Gurzov EN, Pujol-Borrell R, Eizirik DL, Peakman M, Arif, Sefina, Moore, Fabrice, Marks, Katherine, Bouckenooghe, Thomas, Dayan, Colin M

Publikováno v: Diabetes; Aug2011, Vol. 60 Issue 8, p2112-2119, 8p

PTPRK regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity.

Autor: Gilglioni EH; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, B-1070, Brussels, Belgium., Li A; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, B-1070, Brussels, Belgium., St-Pierre-Wijckmans W; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, B-1070, Brussels, Belgium., Shen TK; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, B-1070, Brussels, Belgium.; VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie, B-1050, Brussels, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, B-1050, Brussels, Belgium.; Brussels Center for Redox Biology, Vrije Universiteit Brussel, B-1050, Brussels, Belgium., Pérez-Chávez I; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, B-1070, Brussels, Belgium.; VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie, B-1050, Brussels, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, B-1050, Brussels, Belgium.; Brussels Center for Redox Biology, Vrije Universiteit Brussel, B-1050, Brussels, Belgium., Hovhannisyan G; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, B-1070, Brussels, Belgium., Lisjak M; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, B-1070, Brussels, Belgium., Negueruela J; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, B-1070, Brussels, Belgium., Vandenbempt V; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, B-1070, Brussels, Belgium., Bauzá-Martinez J; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CH, Utrecht, The Netherlands.; Netherlands Proteomics Centre, 3584 CH, Utrecht, The Netherlands., Herranz JM; Hepatology Program, CIMA, University of Navarra, 31009, Pamplona, Spain., Ezeriņa D; VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie, B-1050, Brussels, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, B-1050, Brussels, Belgium.; Brussels Center for Redox Biology, Vrije Universiteit Brussel, B-1050, Brussels, Belgium., Demine S; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, B-1070, Brussels, Belgium., Feng Z; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, B-1070, Brussels, Belgium., Vignane T; Leibniz Institute for Analytical Sciences, ISAS e.V., 44139, Dortmund, Germany., Otero Sanchez L; Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Hôpital Universitaire de Bruxelles, B-1070, Brussels, Belgium.; Laboratory of Experimental Gastroenterology, Université libre de Bruxelles, B-1070, Brussels, Belgium., Lambertucci F; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, B-1070, Brussels, Belgium., Prašnická A; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, B-1070, Brussels, Belgium., Devière J; Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Hôpital Universitaire de Bruxelles, B-1070, Brussels, Belgium.; Laboratory of Experimental Gastroenterology, Université libre de Bruxelles, B-1070, Brussels, Belgium., Hay DC; Centre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, EH16 4UU, UK., Encinar JA; Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDIBE), 03202, Elche, Spain., Singh SP; IRIBHM, Université libre de Bruxelles, B-1070, Brussels, Belgium., Messens J; VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie, B-1050, Brussels, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, B-1050, Brussels, Belgium.; Brussels Center for Redox Biology, Vrije Universiteit Brussel, B-1050, Brussels, Belgium., Filipovic MR; Leibniz Institute for Analytical Sciences, ISAS e.V., 44139, Dortmund, Germany., Sharpe HJ; Signalling Programme, Babraham Institute, Cambridge, CB22 3AT, UK., Trépo E; Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Hôpital Universitaire de Bruxelles, B-1070, Brussels, Belgium.; Laboratory of Experimental Gastroenterology, Université libre de Bruxelles, B-1070, Brussels, Belgium., Wu W; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CH, Utrecht, The Netherlands.; Netherlands Proteomics Centre, 3584 CH, Utrecht, The Netherlands.; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore.; Department of Pharmacy & Pharmaceutical Sciences, National University of Singapore, Singapore, 117543, Singapore., Gurzov EN; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, B-1070, Brussels, Belgium. esteban.gurzov@ulb.be.; WELBIO Department, WEL Research Institute, B-1300, Wavre, Belgium. esteban.gurzov@ulb.be.

Publikováno v: Nature communications [Nat Commun] 2024 Nov 04; Vol. 15 (1), pp. 9522. Date of Electronic Publication: 2024 Nov 04.

HAMSAB diet ameliorates dysfunctional signaling in pancreatic islets in autoimmune diabetes.

Autor: Vandenbempt V; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, 1070 Brussels, Belgium., Eski SE; IRIBHM, Université libre de Bruxelles, 1070 Brussels, Belgium., Brahma MK; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, 1070 Brussels, Belgium., Li A; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, 1070 Brussels, Belgium., Negueruela J; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, 1070 Brussels, Belgium., Bruggeman Y; Clinical and Experimental Endocrinology (CEE), Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Campus Gasthuisberg O&N 1, KU Leuven, 3000 Leuven, Belgium., Demine S; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, 1070 Brussels, Belgium., Xiao P; Inflammatory and Cell Death Signaling in Diabetes group, Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, 1070 Brussels, Belgium., Cardozo AK; Inflammatory and Cell Death Signaling in Diabetes group, Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, 1070 Brussels, Belgium., Baeyens N; Laboratoire de Physiologie et de Pharmacologie, Université Libre de Bruxelles, 1000 Brussels, Belgium., Martelotto LG; Single Cell and Spatial-Omics Laboratory, Adelaide Centre of Epigenetics, University of Adelaide, Adelaide, SA 5005, Australia., Singh SP; IRIBHM, Université libre de Bruxelles, 1070 Brussels, Belgium., Mariño E; Infection and Immunity Program, Biomedicine Discovery Institute, Department of Biochemistry, Monash University, Melbourne, VIC 3800, Australia.; ImmunoBiota Therapeutics Pty Ltd, Melbourne, VIC 3187, Australia., Gysemans C; Clinical and Experimental Endocrinology (CEE), Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Campus Gasthuisberg O&N 1, KU Leuven, 3000 Leuven, Belgium., Gurzov EN; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, 1070 Brussels, Belgium.; WELBIO Department, WEL Research Institute, Avenue Pasteur 6, 1300 Wavre, Belgium.

Publikováno v: IScience [iScience] 2023 Dec 10; Vol. 27 (1), pp. 108694. Date of Electronic Publication: 2023 Dec 10 (Print Publication: 2024).