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PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim.

Autor: Santin I, Moore F, Colli ML, Gurzov EN, Marselli L, Marchetti P, Eizirik DL, Santin, Izortze, Moore, Fabrice, Colli, Maikel L, Gurzov, Esteban N, Marselli, Lorella, Marchetti, Piero, Eizirik, Decio L

Publikováno v: Diabetes; Dec2011, Vol. 60 Issue 12, p3279-3288, 10p

Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB.

Autor: Cunha DA, Ladrière L, Ortis F, Igoillo-Esteve M, Gurzov EN, Lupi R, Marchetti P, Eizirik DL, Cnop M, Cunha, Daniel A, Ladrière, Laurence, Ortis, Fernanda, Igoillo-Esteve, Mariana, Gurzov, Esteban N, Lupi, Roberto, Marchetti, Piero, Eizirik, Décio L, Cnop, Miriam

Publikováno v: Diabetes; Dec2009, Vol. 58 Issue 12, p2851-2862, 12p

HAMSAB diet ameliorates dysfunctional signaling in pancreatic islets in autoimmune diabetes.

Autor: Vandenbempt V; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, 1070 Brussels, Belgium., Eski SE; IRIBHM, Université libre de Bruxelles, 1070 Brussels, Belgium., Brahma MK; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, 1070 Brussels, Belgium., Li A; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, 1070 Brussels, Belgium., Negueruela J; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, 1070 Brussels, Belgium., Bruggeman Y; Clinical and Experimental Endocrinology (CEE), Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Campus Gasthuisberg O&N 1, KU Leuven, 3000 Leuven, Belgium., Demine S; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, 1070 Brussels, Belgium., Xiao P; Inflammatory and Cell Death Signaling in Diabetes group, Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, 1070 Brussels, Belgium., Cardozo AK; Inflammatory and Cell Death Signaling in Diabetes group, Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, 1070 Brussels, Belgium., Baeyens N; Laboratoire de Physiologie et de Pharmacologie, Université Libre de Bruxelles, 1000 Brussels, Belgium., Martelotto LG; Single Cell and Spatial-Omics Laboratory, Adelaide Centre of Epigenetics, University of Adelaide, Adelaide, SA 5005, Australia., Singh SP; IRIBHM, Université libre de Bruxelles, 1070 Brussels, Belgium., Mariño E; Infection and Immunity Program, Biomedicine Discovery Institute, Department of Biochemistry, Monash University, Melbourne, VIC 3800, Australia.; ImmunoBiota Therapeutics Pty Ltd, Melbourne, VIC 3187, Australia., Gysemans C; Clinical and Experimental Endocrinology (CEE), Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Campus Gasthuisberg O&N 1, KU Leuven, 3000 Leuven, Belgium., Gurzov EN; Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, 1070 Brussels, Belgium.; WELBIO Department, WEL Research Institute, Avenue Pasteur 6, 1300 Wavre, Belgium.

Publikováno v: IScience [iScience] 2023 Dec 10; Vol. 27 (1), pp. 108694. Date of Electronic Publication: 2023 Dec 10 (Print Publication: 2024).

Inhibition of RIPK1 kinase does not affect diabetes development: β-Cells survive RIPK1 activation.

Autor: Takiishi T; Inflammation and Cell Death Signalling Group, Laboratoire de Gastroentérologie Expérimental et Endotools, Université libre de Bruxelles (ULB), Brussels, Belgium. Electronic address: tatiana.takiishi@ulb.be., Xiao P; Inflammation and Cell Death Signalling Group, Laboratoire de Gastroentérologie Expérimental et Endotools, Université libre de Bruxelles (ULB), Brussels, Belgium. Electronic address: peng.xiao@ulb.be., Franchimont M; Inflammation and Cell Death Signalling Group, Laboratoire de Gastroentérologie Expérimental et Endotools, Université libre de Bruxelles (ULB), Brussels, Belgium. Electronic address: marie.franchimont96@gmail.com., Gilglioni EH; Signal Transduction and Metabolism Laboratory, Laboratoire de Gastroentérologie Expérimental et Endotools, Université libre de Bruxelles (ULB), Brussels, Belgium. Electronic address: eduardo.hideo.gilglioni@ulb.be., Arroba EN; Inflammation and Cell Death Signalling Group, Laboratoire de Gastroentérologie Expérimental et Endotools, Université libre de Bruxelles (ULB), Brussels, Belgium; Signal Transduction and Metabolism Laboratory, Laboratoire de Gastroentérologie Expérimental et Endotools, Université libre de Bruxelles (ULB), Brussels, Belgium. Electronic address: erick.arroba@ulb.be., Gurzov EN; Signal Transduction and Metabolism Laboratory, Laboratoire de Gastroentérologie Expérimental et Endotools, Université libre de Bruxelles (ULB), Brussels, Belgium; WELBIO, WEL Research Institute, Avenue Pasteur 6, Wavre, 1300, Belgium. Electronic address: esteban.gurzov@ulb.be., Bertrand MJ; VIB Center for inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. Electronic address: mathieu.bertrand@irc.vib-ugent.be., Cardozo AK; Inflammation and Cell Death Signalling Group, Laboratoire de Gastroentérologie Expérimental et Endotools, Université libre de Bruxelles (ULB), Brussels, Belgium. Electronic address: alessandra.kupper.cardozo@ulb.be.

Publikováno v: Molecular metabolism [Mol Metab] 2023 Mar; Vol. 69, pp. 101681. Date of Electronic Publication: 2023 Jan 24.