Data-Driven Derivation of Molecular Substructures That Enhance Drug Activity in Gram-Negative Bacteria.

Autor: Gurvic D; Computational Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom., Leach AG; Division of Pharmacy and Optometry, University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom.; Medchemica Limited, Mereside, Alderley Park, Macclesfield, SK10 4TG, United Kingdom., Zachariae U; Computational Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Apr 28; Vol. 65 (8), pp. 6088-6099. Date of Electronic Publication: 2022 Apr 15.

Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei .

Autor: Alghamdi AH; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Munday JC; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Campagnaro GD; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Gurvic D; Computational Biology Centre for Translational and Interdisciplinary Research, University of Dundee, Dundee, United Kingdom., Svensson F; IOTA Pharmaceuticals Ltd, St Johns Innovation Centre, Cambridge, United Kingdom., Okpara CE; Department of Chemistry, University of Liverpool, Liverpool, United Kingdom., Kumar A; Chemistry Department, Georgia State University, Atlanta, United States., Quintana J; School of Life Sciences, University of Dundee, Dundee, United Kingdom., Martin Abril ME; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Milić P; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Watson L; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Paape D; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Settimo L; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Dimitriou A; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Wielinska J; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Smart G; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Anderson LF; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Woodley CM; Department of Chemistry, University of Liverpool, Liverpool, United Kingdom., Kelly SPY; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Ibrahim HM; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Hulpia F; Laboratory for Medicinal Chemistry, University of Ghent, Ghent, Belgium., Al-Salabi MI; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Eze AA; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Sprenger T; Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom., Teka IA; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Gudin S; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Weyand S; Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom., Field M; School of Life Sciences, University of Dundee, Dundee, United Kingdom.; Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceske Budejovice, Czech Republic., Dardonville C; Instituto de Química Médica - CSIC, Madrid, Spain., Tidwell RR; Department of Pathology and Lab Medicine, University of North Carolina at Chapel Hill, Chapel Hill, United States., Carrington M; Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom., O'Neill P; Department of Chemistry, University of Liverpool, Liverpool, United Kingdom., Boykin DW; Chemistry Department, Georgia State University, Atlanta, United States., Zachariae U; Computational Biology Centre for Translational and Interdisciplinary Research, University of Dundee, Dundee, United Kingdom., De Koning HP; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.

Publikováno v: ELife [Elife] 2020 Aug 11; Vol. 9. Date of Electronic Publication: 2020 Aug 11.

Artificial intelligence applications in the diagnosis and treatment of bacterial infections.

Autor: Xiaoyu Zhang, Deng Zhang, Xifan Zhang, Xin Zhang

Publikováno v: Frontiers in Microbiology; 2024, p1-13, 13p

The Activity of Red Nigerian Propolis and Some of Its Components against Trypanosoma brucei and Trypanosoma congolense.

Autor: Alenezi, Samya S.¹ (AUTHOR), Alenezi, Naif D.¹ (AUTHOR), Ebiloma, Godwin U.^2,3 (AUTHOR), Natto, Manal J.² (AUTHOR), Ungogo, Marzuq A.^2,4 (AUTHOR), Igoli, John O.^1,2,5 (AUTHOR), Ferro, Valerie A.¹ (AUTHOR), Gray, Alexander I.¹ (AUTHOR), Fearnley, James⁶ (AUTHOR), Koning, Harry P. de² (AUTHOR) harry.de-koning@glasgow.ac.uk, Watson, David G.¹ (AUTHOR) harry.de-koning@glasgow.ac.uk

Publikováno v: Molecules. Jan2023, Vol. 28 Issue 2, p622. 12p.

Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential.

Autor: Carruthers, Lauren V., Munday, Jane C., Ebiloma, Godwin U., Steketee, Pieter, Jayaraman, Siddharth, Campagnaro, Gustavo D., Ungogo, Marzuq A., Lemgruber, Leandro, Donachie, Anne‐Marie, Rowan, Tim G., Peter, Rose, Morrison, Liam J., Barrett, Michael P., De Koning, Harry P.

Publikováno v: Molecular Microbiology; Aug2021, Vol. 116 Issue 2, p564-588, 25p