Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Gurusingham Sitta Sittampalam"'
Autor:
Alexander G. Godfrey, Samuel G. Michael, Gurusingham Sitta Sittampalam, Gergely Zahoránszky-Köhalmi
Publikováno v:
Frontiers in Robotics and AI, Vol 7 (2020)
Innovating on the design and function of the chemical bench remains a quintessential challenge of the ages. It requires a deep understanding of the important role chemistry plays in scientific discovery as well a first principles approach to addressi
Externí odkaz:
https://doaj.org/article/364492957ca74ae48609b36965052864
Autor:
Sam Michael, Jameson Travers, Adam Yasgar, Jayme L. Dahlin, Anton Simeonov, Dennis Sheberla, Kelli M. Wilson, Christoph Kreisbeck, Shayne Frebert, Gurusingham Sitta Sittampalam, Alexander G. Godfrey, Sam Elder, Carleen Klumpp-Thomas, Alexey V. Zakharov
Publikováno v:
SLAS technology. 26(6)
Current high-throughput screening assay optimization is often a manual and time-consuming process, even when utilizing design-of-experiment approaches. A cross-platform, Cloud-based Bayesian optimization-based algorithm was developed as part of the N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5c654ca81a6a431826694cfe15c34f
https://pubmed.ncbi.nlm.nih.gov/34813400
https://pubmed.ncbi.nlm.nih.gov/34813400
Autor:
Gurusingham Sitta Sittampalam, Gergely Zahoranszky-Kohalmi, Samuel G. Michael, Alexander G. Godfrey
Publikováno v:
Frontiers in Robotics and AI
Frontiers in Robotics and AI, Vol 7 (2020)
Frontiers in Robotics and AI, Vol 7 (2020)
Innovating on the design and function of the chemical bench remains a quintessential challenge of the ages. It requires a deep understanding of the important role chemistry plays in scientific discovery as well a first principles approach to addressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da368b2c2d62ea2aa6216921b3f4f86
https://doi.org/10.3389/frobt.2020.00024
https://doi.org/10.3389/frobt.2020.00024
Autor:
Gurusingham Sitta Sittampalam, John C. Braisted, David Gerhold, Gregory J. Tawa, Matthew Breen, Christina Mazcko, Gurmit Grewal, Amy K. LeBlanc
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 9, p e1009450 (2021)
PLoS Computational Biology, Vol 17, Iss 9, p e1009450 (2021)
Understanding relationships between spontaneous cancer in companion (pet) canines and humans can facilitate biomarker and drug development in both species. Towards this end we developed an experimental-bioinformatic protocol that analyzes canine tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d007b0210a623870c453e5ff8ef4d8aa
https://doi.org/10.1371/journal.pcbi.1009450
https://doi.org/10.1371/journal.pcbi.1009450
Publikováno v:
Antioxidants & Redox Signaling. 27:511-516
Alzheimer's drugs are failing at a rate of 99.6%, and success rate for drugs designed to help patients with this form of dementia is 47 times less than for drugs designed to help patients with cancers ( www.scientificamerican.com/article/why-alzheime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fef0527c78a189e0ce3c4836f11f195
https://doi.org/10.1089/ars.2017.7065
https://doi.org/10.1089/ars.2017.7065
Publikováno v:
Drug discovery today. 24(1)
As we witness steady progress towards the development of robust, scalable, and reproducible 3D tissue models for preclinical drug testing, there is a need for systematic physiological and pharmacological validation and benchmarking. Ongoing and futur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7c9dcef0eae2cf437e30560519e8a4f
https://pubmed.ncbi.nlm.nih.gov/30071313
https://pubmed.ncbi.nlm.nih.gov/30071313
Autor:
Madhu Lal-Nag, Gurusingham Sitta Sittampalam, Lauren McGee, Sam Michael, Steve Titus, Kyle R. Brimacombe, Marc Ferrer
Publikováno v:
SLAS discovery : advancing life sciences RD. 22(5)
Two-dimensional monolayer cell proliferation assays for cancer drug discovery have made the implementation of large-scale screens feasible but only seem to reflect a simplified view that oncogenes or tumor suppressor genes are the genetic drivers of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2335a5b032c7bf74cabc28b6964b97bc
https://pubmed.ncbi.nlm.nih.gov/28298153
https://pubmed.ncbi.nlm.nih.gov/28298153
Autor:
Peter Hendricks, Alicia Duren, Victor Sanjit Nirmalanandhan, George A. Vielhauer, Gurusingham Sitta Sittampalam
Publikováno v:
Assay and drug development technologies. 8(5)
Cell-monolayer-based assays for chemotherapeutic drug discovery have proven to be highly artificial compared with physiological systems. The objective of this study was to culture cancer cells in a simple 3-dimensional (3D) collagen gel model to stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2297a74168bad22e8fe9496098883541
https://pubmed.ncbi.nlm.nih.gov/20662735
https://pubmed.ncbi.nlm.nih.gov/20662735
Autor:
Roy A. Jensen, Gurusingham Sitta Sittampalam, Joaquina Baranda, Satish Ramalingam, Shrikant Anant, Subhash Padhye, Mojtaba Olyaee, Prasad Dandawate, Dharmalingam Subramaniam, Ossama Tawfik, Prabhu Ramamoorthy, Scott Weir
Publikováno v:
Gastroenterology. 148:S-63
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c29819159be9dadbd75507893ea1897f
https://doi.org/10.1016/s0016-5085(15)30222-5
https://doi.org/10.1016/s0016-5085(15)30222-5
Autor:
Gurusingham Sitta Sittampalam, Sanjit Nirmalanandhan, Raj Somasundaram, Ashorne Krithiesh Mahenthiran
Publikováno v:
Journal of Clinical Oncology. 31:e18523-e18523
e18523 Background: In this in-vitro study, we determined the effects of vitamin C (Ascorbic acid), an essential vitamin, on two different lung cancer cell lines (H358 – Bronchioalveolar Carcinoma and A549 – Epithelial Lung carcinoma) and two norm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c13d9ab7137760d008d0f75b7b91510b
https://doi.org/10.1200/jco.2013.31.15_suppl.e18523
https://doi.org/10.1200/jco.2013.31.15_suppl.e18523