Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Guruprasad, Kuntamallappanavar"'
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109306 (2014)
Voltage/Ca²⁺(i)-gated, large conductance K+ (BK) channels result from tetrameric association of α (slo1) subunits. In most tissues, BK protein complexes include regulatory β subunits that contain two transmembrane domains (TM1, TM2), an extracel
Externí odkaz:
https://doaj.org/article/8fe533e3c6324b669440cf7fc9563e4a
Autor:
Alejandro M. Dopico, Pedro Martín, Guruprasad Kuntamallappanavar, Verónica Milesi, Melisa Moncada
Publikováno v:
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Universidad Nacional de La Plata
instacron:UNLP
Thiazide-like diuretics are the most commonly used drugs to treat arterial hypertension, with their efficacy being linked to their chronic vasodilatory effect. Previous studies suggest that activation of the large conductance voltage- and Ca2+-depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1ace22fd54d308e938a6d0be40e5b0
http://www.nature.com/doifinder/10.1038/aps.2017.133
http://www.nature.com/doifinder/10.1038/aps.2017.133
Autor:
Anna N. Bukiya, Catherine V. Osborn, Myung-Jin Oh, Irena Levitan, Alejandro M. Dopico, Lia Baki, Gregory B. Kowalsky, Avia Rosenhouse-Dantsker, Peter T. Toth, Guruprasad Kuntamallappanavar
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1848(10):2406-2413
Cholesterol is one of the major lipid components of membranes in mammalian cells. In recent years, cholesterol has emerged as a major regulator of ion channel function. The most common effect of cholesterol on ion channels in general and on inwardly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9242bf1e45b9cca79185ca43ffd3918
Autor:
Pedro, Martín, Melisa, Moncada, Guruprasad, Kuntamallappanavar, Alex M, Dopico, Verónica, Milesi
Publikováno v:
Acta pharmacologica Sinica. 39(3)
Thiazide-like diuretics are the most commonly used drugs to treat arterial hypertension, with their efficacy being linked to their chronic vasodilatory effect. Previous studies suggest that activation of the large conductance voltage- and Ca(2+)-depe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::06788c57b463d7f9d709e8335c9b9ae9
https://pubmed.ncbi.nlm.nih.gov/29188803
https://pubmed.ncbi.nlm.nih.gov/29188803
Autor:
Anna N. Bukiya, Bangalore Shivakumar, Aditya K. Singh, Justin Edwards, Guruprasad Kuntamallappanavar, Alejandro M. Dopico
Publikováno v:
Proceedings of the National Academy of Sciences. 111:9313-9318
Ethanol alters BK (slo1) channel function leading to perturbation of physiology and behavior. Site(s) and mechanism(s) of ethanol-BK channel interaction are unknown. We demonstrate that ethanol docks onto a water-accessible site that is strategically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82729c3e09dae1dbf555296c7cf0f943
https://doi.org/10.1073/pnas.1317363111
https://doi.org/10.1073/pnas.1317363111
Publikováno v:
Biophysical Journal. 116:541a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1c0c12e81f1057df68ec4e826cf92ea
https://doi.org/10.1016/j.bpj.2018.11.2911
https://doi.org/10.1016/j.bpj.2018.11.2911
Large conductance, Ca2+ i- and voltage-gated K+ (BK) channels regulate myogenic tone and, thus, arterial diameter. In smooth muscle (SM), BK channels include channel-forming α and auxiliary β1 subunits. BK β1 increases the channel’s Ca2+ sensiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0546aec1d603a52c1c7add1b484121d
https://europepmc.org/articles/PMC5432129/
https://europepmc.org/articles/PMC5432129/
Publikováno v:
International review of neurobiology. 128
In alcohol-naive systems, ethanol (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6e246427bab9aa1fcf805d753fc2d9
https://pubmed.ncbi.nlm.nih.gov/27238266
https://pubmed.ncbi.nlm.nih.gov/27238266
Publikováno v:
The Journal of General Physiology
Large conductance K+ channels of the slo1 family are gated by Ca2+ and voltage and either inhibited or potentiated by ethanol. Kuntamallappanavar and Dopico analyze the effects of ethanol in detail and find that the absence or presence of β subunits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a61a8b7deade84d134ba67aee7a45a
https://pubmed.ncbi.nlm.nih.gov/27799321
https://pubmed.ncbi.nlm.nih.gov/27799321