Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Gurunadh R. Chichili"'
Autor:
Paola Circosta, Angela Rita Elia, Indira Landra, Rodolfo Machiorlatti, Maria Todaro, Sabrina Aliberti, Davide Brusa, Silvia Deaglio, Sabina Chiaretti, Riccardo Bruna, Daniela Gottardi, Massimo Massaia, Filomena Di Giacomo, Anna Rita Guarini, Robin Foà, Peter W. Kyriakides, Rohan Bareja, Olivier Elemento, Gurunadh R. Chichili, Emanuele Monteleone, Paul A. Moore, Syd Johnson, Ezio Bonvini, Alessandro Cignetti, Giorgio Inghirami
Publikováno v:
OncoImmunology, Vol 7, Iss 4 (2018)
Many patients with B-cell malignancies can be successfully treated, although tumor eradication is rarely achieved. T-cell-directed killing of tumor cells using engineered T-cells or bispecific antibodies is a promising approach for the treatment of h
Externí odkaz:
https://doaj.org/article/c9f24a2e69284c5786bd71c31922ae7b
Autor:
Adam R. Root, Wei Cao, Bilian Li, Peter LaPan, Caryl Meade, Jocelyn Sanford, Macy Jin, Cliona O’Sullivan, Emma Cummins, Matthew Lambert, Alfredo D. Sheehan, Weijun Ma, Scott Gatto, Kelvin Kerns, Khetemenee Lam, Aaron M. D’Antona, Lily Zhu, William A. Brady, Susan Benard, Amy King, Tao He, Lisa Racie, Maya Arai, Dianah Barrett, Wayne Stochaj, Edward R. LaVallie, James R. Apgar, Kristine Svenson, Lidia Mosyak, Yinhua Yang, Gurunadh R. Chichili, Liqin Liu, Hua Li, Steve Burke, Syd Johnson, Ralph Alderson, William J. J. Finlay, Laura Lin, Stéphane Olland, William Somers, Ezio Bonvini, Hans-Peter Gerber, Chad May, Paul A. Moore, Lioudmila Tchistiakova, Laird Bloom
Publikováno v:
Antibodies, Vol 5, Iss 1, p 6 (2016)
Bispecific antibodies offer a promising approach for the treatment of cancer but can be challenging to engineer and manufacture. Here we report the development of PF-06671008, an extended-half-life dual-affinity re-targeting (DART®) bispecific molec
Externí odkaz:
https://doaj.org/article/8c0c6589f19a4745bedbcd5e1b1c60a5
Autor:
Gurunadh R, Chichili, Ronald, Smulders, Vicki, Santos, Beth, Cywin, Laura, Kovanda, Charles, Van Sant, Frank, Malinoski, Shite, Sebastian, George, Siber, Richard, Malley
Publikováno v:
Vaccine. 40:4190-4198
Pneumococcal diseases remain prevalent despite available polysaccharide and conjugate vaccines. This phase 1/2 study evaluated safety/tolerability and immunogenicity of a novel 24-valent pneumococcal vaccine (ASP3772) based on high-affinity complexin
Autor:
Syd Johnson, Ezio Bonvini, Jennie Mather, Scott Koenig, Francine Z. Chen, Jennifer G. Brown, Douglas H. Smith, Liqin Liu, Gurunadh R. Chichili, Deryk Loo, Arash Adami, Peter Young, Kathy L. King, Sergey Gorlatov, Monica Licea, Ann Easton, Jeff Hooley, Claudia B. Fieger, Hua Li, Valentina Ciccarone, Steve Burke, Jonathan C. Li, Daorong Liu, Vatana Long, Penny Roberts, Ralph Alderson, Yinhua Yang, Kalpana Shah, Paul A. Moore
We have developed MGD007 (anti-glycoprotein A33 x anti-CD3), a DART protein designed to redirect T cells to target gpA33 expressing colon cancer. The gpA33 target was selected on the basis of an antibody-based screen to identify cancer antigens unive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ba6d82666632826560f5e8ab30de076
https://doi.org/10.1158/1535-7163.c.6538044.v1
https://doi.org/10.1158/1535-7163.c.6538044.v1
Autor:
Syd Johnson, Ezio Bonvini, Jennie Mather, Scott Koenig, Francine Z. Chen, Jennifer G. Brown, Douglas H. Smith, Liqin Liu, Gurunadh R. Chichili, Deryk Loo, Arash Adami, Peter Young, Kathy L. King, Sergey Gorlatov, Monica Licea, Ann Easton, Jeff Hooley, Claudia B. Fieger, Hua Li, Valentina Ciccarone, Steve Burke, Jonathan C. Li, Daorong Liu, Vatana Long, Penny Roberts, Ralph Alderson, Yinhua Yang, Kalpana Shah, Paul A. Moore
Supplementary Table 1: Sixteen-locus STR analysis of tumor tissue and banked CSLC lines Supplementary Table 2: CSLC derivation and characteristics Supplementary Table 3: Immunohistochemical Analysis of Colorectal Cancer Tumor Specimens Supplementary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27335580a8bd3d29129ed45c0ef17bde
https://doi.org/10.1158/1535-7163.22505397
https://doi.org/10.1158/1535-7163.22505397
Autor:
Donald E. Mager, Jean-Michel Scherrmann, Ralph Alderson, Hua Li, Gurunadh R. Chichili, Marylore Chenel, Sylvain Fouliard, Audrey Delmas, Olivia Campagne
Purpose: Flotetuzumab (MGD006 or S80880) is a bispecific molecule that recognizes CD3 and CD123 membrane proteins, redirecting T cells to kill CD123-expressing cells for the treatment of acute myeloid leukemia. In this study, we developed a mathemati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6618cc251164c619f888673f37fe36
https://doi.org/10.1158/1078-0432.c.6525771
https://doi.org/10.1158/1078-0432.c.6525771
Autor:
Donald E. Mager, Jean-Michel Scherrmann, Ralph Alderson, Hua Li, Gurunadh R. Chichili, Marylore Chenel, Sylvain Fouliard, Audrey Delmas, Olivia Campagne
Supplementary figures and tables Figure S1 PK/PD experimental design. This figure details the dose and sampling strategies for the PK/PD endpoints for all animal groups. Figure S2 Detailed structural PK/PD model of MGD006 administrated in cynomolgus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f7c0b9f0ad0394860f380d2dc48fdb
https://doi.org/10.1158/1078-0432.22464651.v1
https://doi.org/10.1158/1078-0432.22464651.v1
Autor:
Justine Calise, Hannah DeBerg, Nahir Garabatos, Sugandhika Khosa, Veronique Bajzik, Lorena Botero Calderon, Kelly Aldridge, Mario Rosasco, Brian C. Ferslew, Tong Zhu, Ronald Smulders, Lisa M. Wheatley, Tanya M. Laidlaw, Tielin Qin, Gurunadh R. Chichili, Daniel C. Adelman, Mary Farrington, David Robinson, David Jeong, Stacie M. Jones, Srinath Sanda, David Larson, William W. Kwok, Carolyn Baloh, Gerald T. Nepom, Erik Wambre, Edwin H. Kim, Kari C. Nadeau, Anna Nowak-Wegrzyn, Robert A. Wood, Hugh A. Sampson, Amy M. Scurlock, Sharon Chinthrajah, Julie Wang, Robert D. Pesek, Sayantani B. Sindher, Mike Kulis, Jacqueline Johnson, Katharine Spain, Denise C. Babineau, Hyunsook Chin, Joy Laurienzo-Panza, null Rachel Yan, null Tielin Qin, Don Whitehouse, Michelle L. Sever, Marshall Plaut, A. Wesley Burks, Gina Marchesini, Kavitha Gilroy, Sylvia Posso, Sabrina Skiba, Thien-Son Nguyen, Adam Wojno, Tuan Nguyen, Vivian Gersuk, Quynh-Anh Nguyen, Jessica Garber, Kimberly O’Brien, Brandon Larson, C. Cousens-Jacobs, Alex Hu
Publikováno v:
Journal of Allergy and Clinical Immunology.
Publikováno v:
Vitamins and hormones. 75
Vitamin A and its active metabolite retinoic acid (RA)(1) play a major role in development, differentiation, and support of various tissues and organs of numerous species. To assure the supply of target tissues with vitamin A, long-lasting stores are
Autor:
Gurunadh R, Chichili, Donatus, Nohr, Jürgen, Frank, Andrea, Flaccus, Paul D, Fraser, Eugenia M A, Enfissi, Hans K, Biesalski
Publikováno v:
The British journal of nutrition. 96(4)
Epidemiological studies show that dietary products rich in carotenoids delay the progression of age-related macular degeneration. Experimental evidence from cellular studies on the antioxidant actions of carotenoids in the retinal pigment epithelium