Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Gurumoorthy, Krishnamoorthy"'
Autor:
Mathangi Janakiraman, Alexei Leliavski, Jeeva Varadarajulu, Dieter Jenne, Gurumoorthy Krishnamoorthy
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract Current effective therapies for autoimmune diseases rely on systemic immunomodulation that broadly affects all T and/or B cell responses. An ideal therapeutic approach would combine autoantigen-specific targeting of both T and B cell effecto
Externí odkaz:
https://doaj.org/article/30973964cd2c4447b73df3c03454c454
Autor:
Clemens Gödel, Birgit Kunkel, Alireza Kashani, Hans Lassmann, Manimozhiyan Arumugam, Gurumoorthy Krishnamoorthy
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-6 (2020)
Abstract The gut microbiota regulates the host immune and nervous systems and plays an important role in the pathogenesis of autoimmune neurological disease multiple sclerosis (MS). There are considerable efforts currently being undertaken to develop
Externí odkaz:
https://doaj.org/article/6dfb79fa0edc46d5a579fa1e52aa5458
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0266589 (2022)
T cells express co-receptors CD4 and CD8, which are involved in the recognition of antigen presented to T cell receptors. The expression of CD4 in thymic hematopoietic cells is crucial for the thymic development and selection of T cells. In this stud
Externí odkaz:
https://doaj.org/article/7dd21b6d3b8c406586069c5fc2881919
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
There is a great interest in developing antigen-specific therapeutic approaches for the treatment of autoimmune diseases without compromising normal immune function. The key challenges are to control all antigen-specific lymphocyte populations that c
Externí odkaz:
https://doaj.org/article/c7c1dda8c7cf435294b88de3f19b6d30
Autor:
Hans Faber, Dunja Kurtoic, Gurumoorthy Krishnamoorthy, Peter Weber, Benno Pütz, Bertram Müller-Myhsok, Frank Weber, Till F. M. Andlauer
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Recent genome-wide association studies have identified over 230 genetic risk loci for multiple sclerosis. Current experimental autoimmune encephalomyelitis (EAE) models requiring active induction of disease may not be optimally suited for the charact
Externí odkaz:
https://doaj.org/article/66a230a0036f44dfb36f3f35c7e1fd08
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Commensal gut microbiota exerts multifarious effects on intestinal and extra-intestinal immune homeostasis. A disruption in the microbial composition of the gut has been associated with many neurological disorders with inflammatory components. Here w
Externí odkaz:
https://doaj.org/article/3f37f81858294005870a73437c9b7235
Autor:
Bärbel Edelmann-Stephan, Andreas Hochhaus, Sabine Brandt, Nicolas Schröder, Florian Perner, Gurumoorthy Krishnamoorthy, Iain Coldham, Amit U. Sinha, Claudia Waskow, Lars Bullinger, Stefanie Jilg, Philipp J. Jost, Martin Ungelenk, Francesca Palandri, Matthias Mann, Rebecca Austin, Frank Edlich, Tina M. Schnöder, Susann Rahmig, Carolin Herzog, Robert Zeiser, Steven W. Lane, Arno Meiler, Thomas Ernst, Christian A. Hübner, Juliane Mohr, Ashok Kumar Jayavelu, Peter R. Mertens, Nicolas Huber, Florian H. Heidel, Ann Mullally, Berend Isermann
Publikováno v:
Nature
Janus kinases (JAKs) mediate responses to cytokines, hormones and growth factors in haematopoietic cells1,2. The JAK gene JAK2 is frequently mutated in the ageing haematopoietic system3,4 and in haematopoietic cancers5. JAK2 mutations constitutively
Publikováno v:
Cancer Immunology, Immunotherapy
The gut microbiota has not only been implicated in the development of some cancers but has also been shown to modulate the efficacy of cancer therapeutics. Although the microbiota is an attractive target in cancer therapy, there is limited data avail
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87876 (2014)
Myelin-specific, pro-inflammatory TH17 cells are widely regarded as the drivers of experimental autoimmune encephalomyelitis (EAE), an animal model for Multiple sclerosis (MS). The factors, responsible for the generation and maintenance of TH17 cells
Externí odkaz:
https://doaj.org/article/a8cf50554cf14bb0b0ad99a01247c5a7
Publikováno v:
Neuromethods ISBN: 9781071612125
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39df7f1db9ce65c5bae93ffc22bd9c8a
https://doi.org/10.1007/978-1-0716-1213-2_7
https://doi.org/10.1007/978-1-0716-1213-2_7