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Bioactive fraction of Musa balbisiana seed mitigates D-galactose-induced brain aging via SIRT1/PGC-1α/FoxO3a activation and intestinal barrier dysfunction by modulating gut microbiota and core metabolites.

Autor: Gurumayum N; Life Sciences Division, Institute of Advanced Study in Science and Technology (IASST), Guwahati-781035, Assam, India; Department of Zoology, Gauhati University, Guwahati, 781014, India., Devi MB; Life Sciences Division, Institute of Advanced Study in Science and Technology (IASST), Guwahati-781035, Assam, India; Department of Biotechnology, Gauhati University, Guwahati, 781014, India., Khound P; Life Sciences Division, Institute of Advanced Study in Science and Technology (IASST), Guwahati-781035, Assam, India; Department of Zoology, Gauhati University, Guwahati, 781014, India., Bhattacharya A; Life Sciences Division, Institute of Advanced Study in Science and Technology (IASST), Guwahati-781035, Assam, India., Sarma H; Life Sciences Division, Institute of Advanced Study in Science and Technology (IASST), Guwahati-781035, Assam, India., Khan MR; Life Sciences Division, Institute of Advanced Study in Science and Technology (IASST), Guwahati-781035, Assam, India. Electronic address: mojibur.khan@iasst.gov.in., Devi R; Life Sciences Division, Institute of Advanced Study in Science and Technology (IASST), Guwahati-781035, Assam, India; Department of Zoology, Gauhati University, Guwahati, 781014, India. Electronic address: rajiasst@gmail.com.

Publikováno v: Free radical biology & medicine [Free Radic Biol Med] 2024 Nov 12; Vol. 226, pp. 43-55. Date of Electronic Publication: 2024 Nov 12.