Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Gurulingappa Hallur"'
Autor:
Chandru Gajendran, Shoichi Fukui, Naveen M. Sadhu, Mohammed Zainuddin, Sridharan Rajagopal, Ramachandraiah Gosu, Sarah Gutch, Saeko Fukui, Casey E. Sheehy, Long Chu, Santosh Vishwakarma, D. A. Jeyaraj, Gurulingappa Hallur, Denisa D. Wagner, Dhanalakshmi Sivanandhan
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Protein arginine deiminases (PAD) 4 is an enzyme that catalyzes citrullination of protein and its role in autoimmune diseases has been established through clinical genetics and gene knock out studies in mice. Further, studies with PAD4 – d
Externí odkaz:
https://doaj.org/article/6dafa58388074e5abe4049b5154399a4
Publikováno v:
The Journal of organic chemistry. 86(17)
A straightforward and feasible palladium-catalyzed direct α-arylation of indane-1,3-dione to 2-substituted aryl/heteroaryl indene-1,3-diones has been disclosed for the first time. Optimization of reaction conditions identified tBu-XPhos as a preferr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e693455e5dd090e6cdbdf40da03749
https://pubmed.ncbi.nlm.nih.gov/34406781
https://pubmed.ncbi.nlm.nih.gov/34406781
Autor:
Brion W. Murray, Anjali Pandey, Bruce Roth, Tracy Saxton, Daniel J. Estes, Himanshu Agrawal, Santosh Vishwakarma, Gurulingappa Hallur, Ishtiyaque Ahmad, Ravi Trivedi, Helen Jenkins, Paul G. Pearson
Publikováno v:
Cancer Research. 82:3332-3332
Exon 20 insertion mutations (Ex20ins) are the third most common type of EGFR oncogenic mutation in lung cancer patients. While several small molecules have been approved (mobocertinib) or are in clinical development (e.g. CLN-081, BDTX-189) none have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c98fba1e1834e4220525f131f5f82db
https://doi.org/10.1158/1538-7445.am2022-3332
https://doi.org/10.1158/1538-7445.am2022-3332
Autor:
Paul G. Pearson, Anjali Pandey, Bruce Roth, Tracy Saxton, Daniel J. Estes, Ravi Trivedi, Himanshu Agrawal, Gurulingappa Hallur, Ishtiyaque Ahmad, Helen Jenkins, Brion W. Murray
Publikováno v:
Cancer Research. 82:3261-3261
Exon 20 insertion mutations (Ex20ins) are the 3rd most common type of EGFR oncogenic mutation in lung cancer patients and are often associated with brain metastases. While several small molecules have been approved (mobocertinib) or are in clinical d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4554fcb2ad8096165b4f8e4ac43d1dd8
https://doi.org/10.1158/1538-7445.am2022-3261
https://doi.org/10.1158/1538-7445.am2022-3261
Autor:
Dhanalakshmi Sivanandhan, Sridharan Rajagopal, Chandru G, Mohd Zainuddin, Naveen Sadhu, Ramachandraiah Gosu, Luca Rastelli, Amir Siddiqui, Sharad Singh, Rudresh G, Sadanand Mullurwar, Saravanan Kandan, Santosh Vishwakarma, Gurulingappa Hallur, Ravi Trivedi, Jeyaraj D A
Publikováno v:
Cancer Research. 82:2646-2646
Background: Peptidyl Arginine Deiminase 4 (PAD4/PADI4) is an enzyme that converts protein arginine or mono-methylarginine to citrulline. The PAD4-mediated hyper citrullination reaction in neutrophils causes the release of nuclear chromatin to form a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c50b8221b2e067934dbf32182a1d0d8d
https://doi.org/10.1158/1538-7445.am2022-2646
https://doi.org/10.1158/1538-7445.am2022-2646
Autor:
Umesh Todmal, Gurulingappa Hallur, Ramesh Mullangi, Sridharan Rajagopal, Suresh P. Sulochana, Ravi Kanth Bhamidipati, Swapan Kumar Samanta, Mohd Zainuddin, Sriram Rajagopal
Publikováno v:
Chromatographia. 81:457-468
A sensitive and rapid LC–MS/MS method was developed and validated for the simultaneous quantitation of five selective KCNQ channel openers, namely ICA-27243, ML-213, PF-05020182, SF-0034 and flupirtine in mice plasma as per regulatory guideline. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc1ef7004177cd1b0e45d532fbab906f
https://doi.org/10.1007/s10337-018-3472-x
https://doi.org/10.1007/s10337-018-3472-x
Autor:
Dhanalakshmi Sivanandhan, Rajendra Kristam, Ramesh Mullangi, Gurulingappa Hallur, Suresh P. Sulochana, Natarajan Tamizharasan, Chandru Gajendran, Palaniswamy Suresh, Logesh Mathivathanan
Publikováno v:
Bioorganic chemistry. 99
Aurora B plays critical role in the process of chromosome condensation and chromosome orientation during the regulation of mitosis. The overexpression of Aurora B has been observed in several tumor types. As a part of our ongoing effort to develop Au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5b0da0914051e6c96c16978172c932
https://pubmed.ncbi.nlm.nih.gov/32283344
https://pubmed.ncbi.nlm.nih.gov/32283344
Autor:
Sreekanth Dittakavi, Vinay Kiran, Ashok Zakkula, Ramesh Mullangi, Buchi Reddy Purra, Gurulingappa Hallur
Publikováno v:
Drug research. 70(1)
Enasidenib is a selective mutant isocitrate dehydrogenase 2 inhibitor approved for the treatment of relapsed and refractory acute myeloid leukemia patients. A sensitive and rapid method has been developed and validated as per regulatory guideline for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300b1f77407ca128318aec68196a10b1
https://pubmed.ncbi.nlm.nih.gov/31652462
https://pubmed.ncbi.nlm.nih.gov/31652462
Autor:
Neeraj Kumar Saini, Suresh P. Sulochana, Buchi Reddy Purra, Prasanthi Daram, Ramesh Mullangi, Gurulingappa Hallur, Mohd Zainuddin
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 153
A sensitive, specific, selective and rapid LC-ESI-MS/MS method has been developed and validated for the quantification of apalutamide in mice plasma using apalutamide-d3 as an internal standard (I.S.). Sample preparation was accomplished through a si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8e321ecf3e9702cfd09d87a664cfd4
https://pubmed.ncbi.nlm.nih.gov/29518645
https://pubmed.ncbi.nlm.nih.gov/29518645
Autor:
Ramesh Mullangi, Gurulingappa Hallur, Rudresh Gangaiah, Mohd Zainuddin, Jeyaraj Duraiswamy A, Pavan Kumar Nagasuri Vsp, Buchi Reddy Purra, Suresh Sulochana P, Sriram Rajagopal
Publikováno v:
Pharmaceutical Analytical Chemistry: Open Access.
A simple, specific, sensitive and rapid LC-ESI-MS/MS method has been developed and validated for the quantification of GSK-199 in mice plasma using warfarin as an internal standard (IS). Sample preparation was accomplished through a liquid-liquid ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::169ee75e7e46fd76b5cf81efb67f9eda
https://doi.org/10.4172/2471-2698.1000124
https://doi.org/10.4172/2471-2698.1000124