Accelerated waning of the humoral response to COVID-19 vaccines in obesity.

Autor: van der Klaauw AA; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-Medical Research Council (MRC) Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Horner EC; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Pereyra-Gerber P; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Agrawal U; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Foster WS; Babraham Institute, Babraham Research Campus, Cambridge, UK., Spencer S; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Vergese B; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-Medical Research Council (MRC) Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; NIHR Cambridge Clinical Research Facility, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Smith M; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-Medical Research Council (MRC) Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Henning E; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-Medical Research Council (MRC) Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Ramsay ID; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK.; Department of Infectious Diseases, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Smith JA; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Guillaume SM; Babraham Institute, Babraham Research Campus, Cambridge, UK., Sharpe HJ; Babraham Institute, Babraham Research Campus, Cambridge, UK., Hay IM; Babraham Institute, Babraham Research Campus, Cambridge, UK.; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK., Thompson S; Babraham Institute, Babraham Research Campus, Cambridge, UK., Innocentin S; Babraham Institute, Babraham Research Campus, Cambridge, UK., Booth LH; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Robertson C; Department of Mathematics and Statistics, University of Strathclyde, Glasgow, UK., McCowan C; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Kerr S; Usher Institute, University of Edinburgh, Edinburgh, UK., Mulroney TE; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., O'Reilly MJ; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Gurugama TP; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Gurugama LP; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Rust MA; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Ferreira A; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Ebrahimi S; Immunology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Clinical Biochemistry, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Ceron-Gutierrez L; Immunology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Clinical Biochemistry, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Scotucci J; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-Medical Research Council (MRC) Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Kronsteiner B; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Dunachie SJ; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; NDM Centre for Global Health Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Translational Gastroenterology Unit, University of Oxford, Oxford, UK.; Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand., Klenerman P; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; NDM Centre for Global Health Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Translational Gastroenterology Unit, University of Oxford, Oxford, UK., Park AJ; Clinical Biochemistry, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Rubino F; Department of Diabetes, King's College London and King's College Hospital NHS Foundation Trust, London, UK., Lamikanra AA; NHS Blood and Transplant, Oxford, UK.; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Stark H; NIHR BioResource, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Kingston N; NIHR BioResource, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Estcourt L; NHS Blood and Transplant, Oxford, UK.; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Harvala H; NHS Blood and Transplant, London, UK., Roberts DJ; NHS Blood and Transplant, Oxford, UK.; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Doffinger R; Immunology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Clinical Biochemistry, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Linterman MA; Babraham Institute, Babraham Research Campus, Cambridge, UK., Matheson NJ; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK.; Department of Infectious Diseases, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; NHS Blood and Transplant, Cambridge, UK., Sheikh A; Usher Institute, University of Edinburgh, Edinburgh, UK. aziz.sheikh@ed.ac.uk., Farooqi IS; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-Medical Research Council (MRC) Institute of Metabolic Science, University of Cambridge, Cambridge, UK. isf20@cam.ac.uk., Thaventhiran JED; MRC Toxicology Unit, University of Cambridge, Cambridge, UK. jedt2@cam.ac.uk.

Publikováno v: Nature medicine [Nat Med] 2023 May; Vol. 29 (5), pp. 1146-1154. Date of Electronic Publication: 2023 May 11.