Zobrazeno 1 - 10
of 829
pro vyhledávání: '"Guru Sonpavde"'
Autor:
Ninet Sinaii, Guru Sonpavde, Amin H Nassar, Min Yuen Teo, Andrea B Apolo, Jonathan E Rosenberg, Giovanni Maria Iannantuono, Elias B A Chandran, Saad O Atiq, Dilara Akbulut, Nicholas I Simon, Abdul Rouf Banday, Salah Boudjadi, Sandeep Gurram, Gisela Butera, Jonathan A Coleman
Publikováno v:
BMJ Oncology, Vol 3, Iss 1 (2024)
Background Mismatch repair deficiency (dMMR) and microsatellite instability-high (MSI-H) occur in a subset of cancers and have been shown to confer sensitivity to immune checkpoint inhibition (ICI); however, there is a lack of prospective data in uro
Externí odkaz:
https://doaj.org/article/d3920c29bad4423893885de5201f3040
Autor:
Lucia Kwak, So Yeon Kim, Guru Sonpavde, Elad Sharon, Abdul Rafeh Naqash, Alessio Cortellini, Rana R McKay, Toni K Choueiri, Thomas Marron, Amin H Nassar, Jeffrey A Sparks, Kaushal Parikh, Frank Aboubakar Nana, Jenny Linnoila, Shruti Gupta, Nicole R LeBoeuf, Elio Adib, Ahmad Al-Hader, Edward El-Am, Dory Freeman, Ahmed Bilal Khalid, Marita Salame, Elias Bou Farhat, Arjun Ravishankar, Bachar Ahmad, David Kaldas, Andrea Malgeri, Ole-Petter R Hamnvik, Thomas Dilling, Elie Najem, Talal El Zarif, Serena Rahme, Caiwei Zhong, Tarek H Mouhieddine
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 3 (2024)
Background Patients with paraneoplastic syndromes (PNS) are excluded from clinical trials involving immune checkpoint inhibitors (ICIs) due to safety concerns. Moreover, real-world data on efficacy and safety is scarce.Methods In this retrospective s
Externí odkaz:
https://doaj.org/article/e3a36a44dc60429b90c5ae6bfb360660
Autor:
Guru Sonpavde, Bradley A McGregor, Charlene Mantia, Praful Ravi, Arvind Ravi, Hans-Dieter Zucht, Petra Budde, Dory Freeman, Jonathan Thomas, Jacob E Berchuck, Ilana Epstein, Behnaz Ahangarian Abhari, Elena Rupieper, Jana Gajewski, Ann-Sophie Schubert, Annika L Kilian, Manuel Bräutigam
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 2 (2024)
Background Comprehensive profiling of autoantibodies (AAbs) in metastatic urothelial cancer (mUC) has not been performed to date. This may aid in diagnosis of UC, uncover novel therapeutic targets in this disease as well as identify associations betw
Externí odkaz:
https://doaj.org/article/97de1e47561e4ef69d8131e83e69bf41
Autor:
Song Gao, Shuaibin Wang, Zhiying Zhao, Chao Zhang, Zhicao Liu, Ping Ye, Zhifang Xu, Baozhu Yi, Kai Jiao, Gurudatta A. Naik, Shi Wei, Soroush Rais-Bahrami, Sejong Bae, Wei-Hsiung Yang, Guru Sonpavde, Runhua Liu, Lizhong Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The β-tubulin family protein TUBB4A is highly expressed in cancer but it’s molecular role is unclear. Here, the authors show that TUBB4A is required to protect the nucleus from genomic instability during migration and that it’s over expression p
Externí odkaz:
https://doaj.org/article/79bf81b74d7341229937c236600eaec4
Autor:
Hasibur Rehman, Darshan S. Chandrashekar, Chakravarthi Balabhadrapatruni, Saroj Nepal, Sai Akshaya Hodigere Balasubramanya, Abigail K. Shelton, Kasey R. Skinner, Ai-Hong Ma, Ting Rao, Sumit Agarwal, Marie-Lisa Eich, Alyncia D. Robinson, Gurudatta Naik, Upender Manne, George J. Netto, C. Ryan Miller, Chong-xian Pan, Guru Sonpavde, Sooryanarayana Varambally, James E. Ferguson III
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
Metastatic urothelial carcinoma is generally incurable with current systemic therapies. Chromatin modifiers are frequently mutated in bladder cancer, with ARID1A-inactivating mutations present in about 20% of tumors. EZH2, a histone methyltransferase
Externí odkaz:
https://doaj.org/article/8e79799b8d1942819fca44a09858150e
Autor:
Antonio Machado Alencar, Guru Sonpavde
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Advances in the treatment of rare tumors like penile cancer were always hampered by the lack of deep comprehension of the molecular biology and genomic and epigenomic alterations involved in carcinogenesis and tumor progression, as well as by the dif
Externí odkaz:
https://doaj.org/article/d73190620590447084d8ac36048b7909
Autor:
Suryadipto Sarkar, Kong Min, Waleed Ikram, Ryan W. Tatton, Irbaz B. Riaz, Alvin C. Silva, Alan H. Bryce, Cassandra Moore, Thai H. Ho, Guru Sonpavde, Haidar M. Abdul-Muhsin, Parminder Singh, Teresa Wu
Publikováno v:
Cancers, Vol 15, Iss 6, p 1673 (2023)
Accurate clinical staging of bladder cancer aids in optimizing the process of clinical decision-making, thereby tailoring the effective treatment and management of patients. While several radiomics approaches have been developed to facilitate the pro
Externí odkaz:
https://doaj.org/article/da6a23fb62a04e07a4317c82410a7ae4
Autor:
Guru Sonpavde, Na Li, Zheng Zhu, Fan Cheng, Shaoming Zhu, A-Hong Ma, Elio Adib, Ting Rao, Kaiyuan Ni, Veera Chandra Sekhar Reddy Chittepu, Rao Prabhala, Juan Garisto Risco, David Kwiatkowski, Kent Mouw, Chong-xian Pan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 11 (2021)
Externí odkaz:
https://doaj.org/article/934d422d19464781b6e424dfea9fbd98
Autor:
Pooja Ghatalia, Jennifer Gordetsky, Fengshen Kuo, Essel Dulaimi, Kathy Q. Cai, Karthik Devarajan, Sejong Bae, Gurudatta Naik, Timothy A. Chan, Robert Uzzo, A. Ari Hakimi, Guru Sonpavde, Elizabeth Plimack
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)
Abstract Background The tumor immune microenvironment has become the focus of research in clear cell renal cell carcinoma (ccRCC) due to its important role in immune surveillance post nephrectomy. This study investigates the correlation of tumor infi
Externí odkaz:
https://doaj.org/article/bbcccb8b0e2a4e59abb6e184d36b4fe3
Autor:
Jonathan Thomas, Guru Sonpavde
Publikováno v:
Cancers, Vol 14, Iss 7, p 1795 (2022)
Despite the introduction of immune checkpoint inhibitors and antibody–drug conjugates to the management of advanced urothelial carcinoma, the disease is generally incurable. The increasing incorporation of next-generation sequencing of tumor tissue
Externí odkaz:
https://doaj.org/article/0fba8f0c66c64eb0815e8892bbd1d052