Výsledky vyhledávání - "Guru Ramamoorthy"

Abstract 2572: A novel strategy for PLK1 kinase inhibition by allosterically targeting the Polo Box Domain

Autor: Danda Chapagai, Merissa Baxter, Sandra Craig, Guru Ramamoorthy, Jessy Stafford, Sikirzhytski Vitali, Elmar Nurmemmedov, Campbell McInnes, Michael D. Wyatt

Publikováno v: Cancer Research. 82:2572-2572

Polo Like Kinase 1 (PLK1) is only expressed in dividing cells and plays a critical role in several stages of mitosis. PLK1 is overexpressed in many tumor types. PLK1 inhibition selectively kills cancer cells because they are dependent on the mitotic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::819a92c8aff3c9b63b0ee0197c56f064
https://doi.org/10.1158/1538-7445.am2022-2572

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Abstract 1241: Converting high affinity peptides to non-peptidic inhibitors via REPLACE: Novel and new strategies in targeting PLK1 Polo Box Domain (PBD) for anti-cancer therapy

Autor: Michael D. Wyatt, Sandra Craig, Elmar Nurmemmedov, McInnes Campbell, Danda Chapagai, Merissa Baxter, Guru Ramamoorthy

Publikováno v: Cancer Research. 81:1241-1241

Polo Like Kinase 1 (PLK1) is only expressed in dividing cells and plays a critical role in several stages of mitosis. PLK1 is highly expressed in tumors of various origins while its expression is largely absent in normal tissues. PLK1 inhibition sele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14e5be833e71e108181b7a18994d63b2
https://doi.org/10.1158/1538-7445.am2021-1241

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