Výsledky vyhledávání - "Gursev S Dhaunsi"

Akademický článek

Association of protein tyrosine phosphatase non-receptor type 22 gene functional variant C1858T, HLA-DQ/DR genotypes and autoantibodies with susceptibility to type-1 diabetes mellitus in Kuwaiti Arabs.

Autor: Mohammad Z Haider, Majedah A Rasoul, Maria Al-Mahdi, Hessa Al-Kandari, Gursev S Dhaunsi

Publikováno v: PLoS ONE, Vol 13, Iss 6, p e0198652 (2018)

The incidence of type-1 Diabetes Mellitus (T1DM) has increased steadily in Kuwait during recent years and it is now considered amongst the high-incidence countries. An interaction between susceptibility genes, immune system mediators and environmenta

Externí odkaz: https://doaj.org/article/07c155dd901f452981bb00005a9c61fc

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Akademický článek

Transactivation of ErbB Family of Receptor Tyrosine Kinases Is Inhibited by Angiotensin-(1-7) via Its Mas Receptor.

Autor: Saghir Akhtar, Bindu Chandrasekhar, Sreeja Attur, Gursev S Dhaunsi, Mariam H M Yousif, Ibrahim F Benter

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0141657 (2015)

Transactivation of the epidermal growth factor receptor (EGFR or ErbB) family members, namely EGFR and ErbB2, appears important in the development of diabetes-induced vascular dysfunction. Angiotensin-(1-7) [Ang-(1-7)] can prevent the development of

Externí odkaz: https://doaj.org/article/c133290b35db4e68aa2f3e080bf07c45

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Akademický článek

Enzymatic testing for mucopolysaccharidosis type I in Kuwaiti newborns: a preliminary study toward newborn screening

Autor: Hind Alsharhan, Mohammad Z. Haider, Bann Qadoura, Mariam Ayed, Gursev S. Dhaunsi, Hessa Alkandari

Publikováno v: Frontiers in Pediatrics, Vol 12 (2024)

Mucopolysaccharidosis type I (MPS I) is an autosomal recessive lysosomal storage disorder characterized by deficient or absent α-L-iduronidase (IDUA) enzyme activity due to pathogenic variants in the IDUA gene. Early treatment with hematopoietic ste

Externí odkaz: https://doaj.org/article/55229be0408f4bd5805919feb32bcfde

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Akademický článek

Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction.

Autor: Saghir Akhtar, Mariam H M Yousif, Gursev S Dhaunsi, Fatma Sarkhouh, Bindu Chandrasekhar, Sreeja Attur, Ibrahim F Benter

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e67813 (2013)

Diabetes mellitus leads to vascular complications but the underlying signalling mechanisms are not fully understood. Here, we examined the role of ErbB2 (HER2/Neu), a transmembrane receptor tyrosine kinase of the ErbB/EGFR (epidermal growth factor re

Externí odkaz: https://doaj.org/article/9828ec605115477086f99b23630bf5c1

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Selective receptor-mediated impairment of growth factor activity in neonatal- and X-linked adrenoleukodystrophy patients

Autor: Mazen Al-Essa, Gursev S. Dhaunsi

Publikováno v: Journal of Pediatric Endocrinology and Metabolism. 32:733-738

Background Neonatal adrenoleukodystrophy (n-ALD) and X-linked ALD (X-ALD) patients present with demyelination, poor growth and progressive mental retardation. Growth factors are known to play a vital role in the development of children. Objective To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c5e2a76db2868f889dd1d5769e52e6
https://doi.org/10.1515/jpem-2018-0540

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Receptor-mediated attenuation of insulin-like growth factor-1 activity by galactose-1-phosphate in neonate skin fibroblast cultures: Galactosemia pathogenesis

Autor: Gursev S. Dhaunsi, Mazen Al-Essa

Publikováno v: Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 29(4)

BACKGROUND The pathogenesis of classical galactosemia, a rare metabolic disorder associated with developmental complications in neonates and children due to inherited deficiency of galactose-1-phosphate (Gal-1-P) uridylyltransferase (GALT), is known

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89dbc76ee7a0a941a11b08572536c90
https://pubmed.ncbi.nlm.nih.gov/32356415

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IgA Enhances IGF-1 Mitogenic Activity Via Receptor Modulation in Glomerular Mesangial Cells: Implications for IgA-Induced Nephropathy

Autor: Gursev S. Dhaunsi, Amal Al-Eisa

Publikováno v: Kidney & Blood Pressure Research, Vol 42, Iss 3, Pp 391-397 (2017)

Background/Aim: Glomerulonephritis due to mesangial proliferation is responsible for renal dysfunction in IgA nephropathy (IgAN), however molecular mechanisms of pathogenesis are not well known. We examined the effect of IgA on Insulin-like Growth Fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6210060a9b379a23d2208e0cad6fd638
http://www.karger.com/Article/FullText/478736

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Relationship of four vitamin D receptor gene polymorphisms with type 1 diabetes mellitus susceptibility in Kuwaiti children

Autor: Maria Al-Mahdi, Gursev S. Dhaunsi, Hessa Al-Kandari, Majedah A. Rasoul, Mohammad Z. Haider

Publikováno v: BMC Pediatrics, Vol 19, Iss 1, Pp 1-13 (2019)
BMC Pediatrics

Background The incidence of type 1 diabetes mellitus (T1DM) in Kuwait is amongst the highest in the world. Vitamin D is considered to be involved in immune modulation and its deficiency contribute to autoimmune destruction of insulin producing beta c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2e4518446b355c6c04266ba5d4975d
https://doi.org/10.1186/s12887-019-1448-0

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