Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Gurpreet K, Singhera"'
Autor:
Samuel James Brake, Wenying Lu, Collin Chia, Greg Haug, Josie Larby, Ashutosh Hardikar, Gurpreet K. Singhera, Tillie L. Hackett, Mathew Suji Eapen, Sukhwinder Singh Sohal
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundCOPD is a common disease characterized by respiratory airflow obstruction. TGF-β1 and SMAD pathway is believed to play a role in COPD pathogenesis by driving epithelial mesenchymal transition (EMT).MethodsWe investigated TGF-β1 signalling
Externí odkaz:
https://doaj.org/article/1785ac62c9de46619da72af6e7aa262d
Publikováno v:
Viruses, Vol 15, Iss 8, p 1655 (2023)
The airway epithelium, which lines the conducting airways, is central to the defense of the lungs against inhaled particulate matter and pathogens such as SARS-CoV-2, the virus that causes COVID-19. Recognition of pathogens results in the activation
Externí odkaz:
https://doaj.org/article/53dd9de1d8f546c7874f7020fb2a0712
Autor:
Nan Yang, Gurpreet K. Singhera, Yi Xuan Yan, Michael P. Pieper, Janice M. Leung, Don D. Sin, Delbert R. Dorscheid
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-11 (2021)
Abstract Background Airway inflammation is a key feature of chronic obstructive pulmonary disease (COPD) and inhaled corticosteroids (ICS) remain the main treatment for airway inflammation. Studies have noted the increased efficacy of ICS and long-ac
Externí odkaz:
https://doaj.org/article/4a2612dc4d8a4f9d86f3aef858016673
Hedgehog Signaling as a Therapeutic Target for Airway Remodeling and Inflammation in Allergic Asthma
Autor:
Anthony Tam, Emmanuel Twumasi Osei, Chung Y. Cheung, Michael Hughes, Chen X. Yang, Kelly M. McNagny, Delbert R. Dorscheid, Gurpreet K. Singhera, Teal S. Hallstrand, Stephanie Warner, James C. Hogg, Tillie L. Hackett, Chinten J. Lim, Don D. Sin
Publikováno v:
Cells, Vol 11, Iss 19, p 3016 (2022)
Genome-wide association studies (GWAS) have shown that variants of patched homolog 1 (PTCH1) are associated with lung function abnormalities in the general population. It has also been shown that sonic hedgehog (SHH), an important ligand for PTCH1, i
Externí odkaz:
https://doaj.org/article/dd1914f393004b81bde0752df491967b
Autor:
Luka Culibrk, Carys A. Croft, Amreen Toor, S. Jasemine Yang, Gurpreet K. Singhera, Delbert R. Dorscheid, Margo M. Moore, Scott J. Tebbutt
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Aspergillus fumigatus is an opportunistic fungal pathogen capable of causing severe infection in humans. One of the limitations in our understanding of how A. fumigatus causes infection concerns the initial stages of infection, notably the initial in
Externí odkaz:
https://doaj.org/article/2a73000fcaec47289cdb1e7974060575
Autor:
Rogerio Pezato, Aldo Cassol Stamm, Richard Douglas, Joseph K. Han, Philip G. Chen, Carlos Diógenes Pinheiro Neto, Miguel Soares Tepedino, Narinder Singh, Leonardo Balsalobre, Chang Hwan Ryu, Luciano Gregório, Sharif Amatrafi, Alexandre Wady Debes Felippu, Enrique Iturriaga, Ronaldo Nunes Toledo, Filippo Cascio, Camilla Dassi, Feras Alkholaiwi, Thiago Freire Pinto Bezerra, Amin Javer, Daniel Lorena Dutra, Alkis James Psaltis, Débora Petrungaro Migueis, Nasser Almutari, Melissa Ameloti Gomes Avelino, Dakshika Abeydeera Gunaratne, Alexandre Felippu, Fábio de Rezende Pinna, Márcio Nakanishi, Claudina A. Perez‐Novo, Gurpreet K. Singhera, Garret Choby, Eric W. Wang, Zara M. Patel, Andrew Thamboo
Publikováno v:
International Forum of Allergy & Rhinology
International forum of allergy & rhinology
International forum of allergy & rhinology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c7e94f46eecabddf20a48d283a320b
https://doi.org/10.1002/alr.23150
https://doi.org/10.1002/alr.23150
Autor:
Ling Vicky Li, Dominik Witzigmann, Gurpreet K. Singhera, Chen X. Yang, Tillie-Louise Hackett, James C. Hogg, Pascal Leclair, Jayesh A. Kulkarni, Pieter R. Cullis, Xuan Li, Delbert R. Dorscheid, Don D. Sin, Chinten James Lim, Anthony Tam
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 321:L377-L391
Genome-wide association studies have shown that a gene variant in the Family with sequence similarity 13, member A (FAM13A) is strongly associated with reduced lung function and the appearance of respiratory symptoms in patients with chronic obstruct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2260812509351341d8be551a444a1234
https://doi.org/10.1152/ajplung.00477.2020
https://doi.org/10.1152/ajplung.00477.2020
Autor:
Amreen Toor, Luka Culibrk, Gurpreet K Singhera, Kyung-Mee Moon, Anna Prudova, Leonard J Foster, Margo M Moore, Delbert R Dorscheid, Scott J Tebbutt
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0209652 (2018)
Aspergillus fumigatus (A. fumigatus) is a wide-spread fungus that is a potent allergen in hypersensitive individuals but also an opportunistic pathogen in immunocompromised patients. It reproduces asexually by releasing airborne conidiospores (conidi
Externí odkaz:
https://doaj.org/article/5fe443b3cb4847f19404f9779be421f7
Autor:
Wenying Lu, Colllin Chia, Mathew Suji Eapen, James Markos, Greg Haug, Tillie L. Hackett, Josie Larby, Sukhwinder Singh Sohal, Gurpreet K. Singhera, Ashutosh Hardikar
Publikováno v:
Molecular pathology and functional genomics.
Aim: We previously provided evidence that EMT is active in patients with chronic airflow limitation. We now illustrate EMT changes in a wider demographic patient group consisting of COPD current and ex-smokers (COPD-CS, COPD-ES), small airway disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b1c3abc3ed62f09296509ffc75d3e2b
https://doi.org/10.1183/13993003.congress-2021.pa2382
https://doi.org/10.1183/13993003.congress-2021.pa2382
Autor:
James Markos, Andrew Williams, Wenying Lu, Prem Bhattarai, Gurpreet K. Singhera, Greg Haug, Josie Larby, Surajit Dey, Collin Chia, Mathew Suji Eapen, Tillie L. Hackett, Sukhwinder Singh Sohal, Stephen Myers, Archana Vijay Gaikwad, Ashutosh Hardikar
Publikováno v:
Molecular pathology and functional genomics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92f70c4326980da77fa821afac1e4b5d
https://doi.org/10.1183/13993003.congress-2021.oa1216
https://doi.org/10.1183/13993003.congress-2021.oa1216