Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Gurpanna Saggu"'
Autor:
Koshu Okubo, Michael D. Brenner, Xavier Cullere, Gurpanna Saggu, Myra L. Patchen, Nandita Bose, Saki Mihori, Zhou Yuan, Clifford A. Lowell, Cheng Zhu, Tanya N. Mayadas
Publikováno v:
Cell Reports, Vol 35, Iss 7, Pp 109142- (2021)
Summary: The interaction of the human FcγRIIA with immune complexes (ICs) promotes neutrophil activation and thus must be tightly controlled to avoid damage to healthy tissue. Here, we demonstrate that a fungal-derived soluble β-1,3/1,6-glucan bind
Externí odkaz:
https://doaj.org/article/9a4ac42e04014a60b236ae9a01a774d1
Autor:
Gurpanna Saggu, Koshu Okubo, Yunfeng Chen, Ravi Vattepu, Naotake Tsuboi, Florencia Rosetti, Xavier Cullere, Nathaniel Washburn, Suhail Tahir, Aaron M. Rosado, Steven M. Holland, Robert M. Anthony, Mehmet Sen, Cheng Zhu, Tanya N. Mayadas
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Deposited immune complexes (IC) promote neutrophil recruitment, but the fine tuning of this process is still unclear. Here the authors show that the cis interaction of the IC receptor, FcγRIIA and CD18 integrin, Mac-1, on the neutrophil surface modu
Externí odkaz:
https://doaj.org/article/94c549222fd542cf9308dbd596a1cb4c
Autor:
Adriana Patricia Granados Martinez, Patrícia Antonia Estima Abreu, Silvio de Arruda Vasconcellos, Paulo Lee Ho, Viviana P. Ferreira, Gurpanna Saggu, Angela Silva Barbosa, Lourdes Isaac
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Properdin (P) is a positive regulatory protein that stabilizes the C3 convertase and C5 convertase of the complement alternative pathway (AP). Several studies have suggested that properdin can bind directly to the surface of certain pathogens regardl
Externí odkaz:
https://doaj.org/article/fcda22c2f66e42f5b048706ac202455a
Autor:
Konrad Buscher, Huiyu Wang, Xueli Zhang, Paul Striewski, Benedikt Wirth, Gurpanna Saggu, Stefan Lütke-Enking, Tanya N. Mayadas, Klaus Ley, Lydia Sorokin, Jian Song
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
Neutrophils are critical in preventing the transition of acute peritoneal infection to sepsis. Here the authors show in three mouse models of peritonitis that neutrophils enter the abdominal cavity via high endothelial venules of the greater omentum,
Externí odkaz:
https://doaj.org/article/15cfcd382e7148ceb82297fa2012f9df
Autor:
Adam Z. Blatt, Gurpanna Saggu, Claudio Cortes, Andrew P. Herbert, David Kavanagh, Daniel Ricklin, John D. Lambris, Viviana P. Ferreira
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Platelet/granulocyte aggregates (PGAs) increase thromboinflammation in the vasculature, and PGA formation is tightly controlled by the complement alternative pathway (AP) negative regulator, Factor H (FH). Mutations in FH are associated with the prot
Externí odkaz:
https://doaj.org/article/09c0658794a54566a9b1dbb4da4cba14
Autor:
Serge Y. Fuchs, Dmitry I. Gabrilovich, Yulia Nefedova, Allison Berger, Gurpanna Saggu, Jose R. Conejo-Garcia, M. Andres Blanco, Daniel P. Beiting, Tara Lee Costich, Noreen McBrearty, Jun Gui, Fangxue Yan, Raghavendra Basavaraja, Jinyang Li, Vivek S. Tomar, Hongru Zhang
Supplementary Tables 1, 2, and 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546bad13fd141f8f1defa7dae784bf9e
https://doi.org/10.1158/2326-6066.22545902
https://doi.org/10.1158/2326-6066.22545902
Autor:
Serge Y. Fuchs, Dmitry I. Gabrilovich, Yulia Nefedova, Allison Berger, Gurpanna Saggu, Jose R. Conejo-Garcia, M. Andres Blanco, Daniel P. Beiting, Tara Lee Costich, Noreen McBrearty, Jun Gui, Fangxue Yan, Raghavendra Basavaraja, Jinyang Li, Vivek S. Tomar, Hongru Zhang
Fragility of regulatory T (Treg) cells manifested by the loss of neuropilin-1 (NRP1) and expression of IFNγ undermines the immune suppressive functions of Treg cells and contributes to the success of immune therapies against cancers. Intratumoral Tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b2160ed088e90c87fe5fb79aaab1bd
https://doi.org/10.1158/2326-6066.c.6551048.v1
https://doi.org/10.1158/2326-6066.c.6551048.v1
Autor:
Serge Y. Fuchs, Dmitry I. Gabrilovich, Yulia Nefedova, Allison Berger, Gurpanna Saggu, Jose R. Conejo-Garcia, M. Andres Blanco, Daniel P. Beiting, Tara Lee Costich, Noreen McBrearty, Jun Gui, Fangxue Yan, Raghavendra Basavaraja, Jinyang Li, Vivek S. Tomar, Hongru Zhang
Supplementary Figure from Protection of Regulatory T Cells from Fragility and Inactivation in the Tumor Microenvironment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569162bd4707629449e8049aabe81276
https://doi.org/10.1158/2326-6066.22545905
https://doi.org/10.1158/2326-6066.22545905
Autor:
Serge Y. Fuchs, Dmitry I. Gabrilovich, Yulia Nefedova, Allison Berger, Gurpanna Saggu, Jose R. Conejo-Garcia, M. Andres Blanco, Daniel P. Beiting, Tara Lee Costich, Noreen McBrearty, Jun Gui, Fangxue Yan, Raghavendra Basavaraja, Jinyang Li, Vivek S. Tomar, Hongru Zhang
Supplementary Data from Protection of Regulatory T Cells from Fragility and Inactivation in the Tumor Microenvironment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ebcb7cdb23f17e6ced8aaf06d2b8c0
https://doi.org/10.1158/2326-6066.22545911.v1
https://doi.org/10.1158/2326-6066.22545911.v1
Autor:
Hongru Zhang, Vivek S. Tomar, Jinyang Li, Raghavendra Basavaraja, Fangxue Yan, Jun Gui, Noreen McBrearty, Tara Lee Costich, Daniel P. Beiting, M. Andres Blanco, Jose R. Conejo-Garcia, Gurpanna Saggu, Allison Berger, Yulia Nefedova, Dmitry I. Gabrilovich, Serge Y. Fuchs
Publikováno v:
Cancer Immunol Res
Fragility of regulatory T (Treg) cells manifested by the loss of neuropilin-1 (NRP1) and expression of IFNγ undermines the immune suppressive functions of Treg cells and contributes to the success of immune therapies against cancers. Intratumoral Tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a20922e070b73ffc8481106619e1a90b
https://europepmc.org/articles/PMC9722544/
https://europepmc.org/articles/PMC9722544/