Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Gurol Tuncman"'
Autor:
Idit Ron, Ediz S. Calay, Amir Tirosh, Rinat Livne, Amit Tirosh, Sophie Ron, Moran Rathaus, Abdullah Yalcin, Yankun G. Lee, Gurol Tuncman, Gökhan S. Hotamisligil, Ana Paula Arruda, Neri Minsky
Publikováno v:
Cell Metab
Endoplasmic reticulum stress (ERS) has a pathophysiological role in obesity-associated insulin resistance. Yet, the coordinated tissue response to ERS remains unclear. Increased connexin 43 (Cx43)-mediated intercellular communication has been implica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea9ed2125c6831fd7dd6fee22672242d
https://doi.org/10.1016/j.cmet.2021.07.005
https://doi.org/10.1016/j.cmet.2021.07.005
Autor:
Ediz S. Calay, Amir Tirosh, Idit Ron, Iris Shai, Rajesh Garg, Lu Qi, Karen Inouye, Kathryn Claiborn, Michael A.D. Alcala, Gurol Tuncman, Gökhan S. Hotamisligil, Kosei Eguchi, Rinat Livne, Yoriko Heianza, Kenneth Hollander, Moran Rathaus
Publikováno v:
Science Translational Medicine. 11
The short-chain fatty acid propionate is a potent inhibitor of molds that is widely used as a food preservative and endogenously produced by gut microbiota. Although generally recognized as safe by the U.S. Food and Drug Administration, the metabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71081d5f65d685fd3d673e4502ea9b2
https://doi.org/10.1126/scitranslmed.aav0120
https://doi.org/10.1126/scitranslmed.aav0120
Autor:
Presila Bejo, Eric B. Rimm, Nurdan Dagtekin, Eric Vaillancourt, Gurol Tuncman, Gökhan S. Hotamisligil, M. Furkan Burak, Cem Z. Görgün, Lydia Liu
Publikováno v:
Journal of the Endocrine Society
Asthma is a chronic inflammatory disease of the airways with an increasing prevalence but limited treatment options. Although the pathogenesis is not fully understood, it has a major immunometabolic component including contribution of lipid mediators
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93af9ad5cf3816898a534f263fa2a94e
https://doi.org/10.1210/js.2019-or01-1
https://doi.org/10.1210/js.2019-or01-1
Autor:
Kosei Eguchi, Hanna Hailu, Helen Neale, Geofrey Odede, Alexandra Lee, Amir Tirosh, Ediz S. Calay, Gabriel Birrane, Louise Howells, Carl Brendan Doyle, Shauna West, Adrian Moore, Ariel White, Karen Inouye, Gökhan S. Hotamisligil, Daniel John Lightwood, Rachel Garlish, Gurol Tuncman, Motohiro Sekiya, M. Furkan Burak
Publikováno v:
Science Translational Medicine. 7
The lipid chaperone aP2/FABP4 has been implicated in the pathology of many immunometabolic diseases, including diabetes in humans, but aP2 has not yet been targeted for therapeutic applications. aP2 is not only an intracellular protein but also an ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2aa3c865643cc9ad4076c128a1871f
https://doi.org/10.1126/scitranslmed.aac6336
https://doi.org/10.1126/scitranslmed.aac6336
Autor:
Gökhan S. Hotamisligil, Giovanni Solinas, Lufen Chang, Michael Karin, Jiro Hirosumi, Gurol Tuncman
Publikováno v:
Proceedings of the National Academy of Sciences. 103:10741-10746
The c-Jun N-terminal kinases (JNKs) are key regulators of inflammation and interfere with insulin action in cultured cells and whole animals. Obesity increases total JNK activity, and JNK1, but not JNK2, deficiency results in reduced adiposity and im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2da41e01ae0e2826d3234eaeb95c946
https://doi.org/10.1073/pnas.0603509103
https://doi.org/10.1073/pnas.0603509103
Autor:
Gurol Tuncman, Qiong Cao, Umut Ozcan, Laurie H. Glimcher, Ann-Hwee Lee, Cem Z. Görgün, Gökhan S. Hotamisligil, Neal N. Iwakoshi, Erkan Yilmaz, Esra Özdelen
Publikováno v:
Science. 306:457-461
Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell culture and mouse models, we show that obesity causes endoplasmic reticulum (ER) stress. This stress in turn leads to suppressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2db8c1bc06610ce62994a440d73932
https://doi.org/10.1126/science.1103160
https://doi.org/10.1126/science.1103160
Autor:
Işık Bökesoy, Rivka Yona, Gurol Tuncman, Ajlan Tükün, Varda Rotter, Miron Prokocimer, Shoshana Peller, Akin Uysal, Yulia Kopilova, Naomi Goldfinger, Halil Gürhan Karabulut
Publikováno v:
Genes, Chromosomes and Cancer. 21:2-7
The TP53 gene has been extensively studied in patients with chronic myeloid leukemia (CML), both in chronic phase and in blast crisis. Mutations in the gene were found in up to 30% of the patients, especially among those in blast crisis. We report th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a68356464876dadc620ea37e06038c0
https://doi.org/10.1002/(sici)1098-2264(199801)21:1<2::aid-gcc2>3.0.co
https://doi.org/10.1002/(sici)1098-2264(199801)21:1<2::aid-gcc2>3.0.co
Autor:
Lisa M. Rickey, Masato Furuhashi, Karen Inouye, Jared R. Mayers, Baris C. Ercal, Haiming Cao, Meric Erikci Ertunc, Ariel White, M. Furkan Burak, Gurol Tuncman, Gökhan S. Hotamisligil, Motohiro Sekiya
SummaryProper control of hepatic glucose production is central to whole-body glucose homeostasis, and its disruption plays a major role in diabetes. Here, we demonstrate that although established as an intracellular lipid chaperone, aP2 is in fact ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae65e540a31c5124f9769804b1379d3
https://europepmc.org/articles/PMC3755450/
https://europepmc.org/articles/PMC3755450/
Autor:
Gökhan S. Hotamisligil, Haiming Cao, Raquel Fucho, Cem Z. Görgün, Masato Furuhashi, Gurol Tuncman
Adipose tissue inflammation is a characteristic of obesity. However, the mechanisms that regulate this inflammatory response and link adipose inflammation to systemic metabolic consequences are not fully understood. In this study, we have taken advan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bece07c3e484d39466431e3f501ed7a0
https://europepmc.org/articles/PMC2423863/
https://europepmc.org/articles/PMC2423863/
Autor:
Eric B. Rimm, Gökhan S. Hotamisligil, X. Hom, Ebru Erbay, I. De Vivo, Hannia Campos, Gurol Tuncman
Obesity and the associated pathologies including dyslipidemia, insulin resistance, type 2 diabetes, and cardiovascular disease constitute a major threat to global human health. Yet, the genetic factors that differentially predispose individuals to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c826037984c2de3077ba348e5b351e1c
https://europepmc.org/articles/PMC1447594/
https://europepmc.org/articles/PMC1447594/