Dysregulation of cholesterol homeostasis is an early signal of β-cell proteotoxicity characteristic of type 2 diabetes.

Autor: Gurlo T; Larry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States., Liu R; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California, United States., Wang Z; Larry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States., Hoang J; Larry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States., Ryazantsev S; Electron Imaging Center, California Nano Systems Institute, University of California, Los Angeles, Los Angeles, California, United States., Daval M; Larry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States., Butler AE; Larry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States., Yang X; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California, United States.; Molecular, Cellular, and Integrative Physiology Interdepartmental Program, University of California, Los Angeles, Los Angeles, California, United States., Blencowe M; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California, United States.; Molecular, Cellular, and Integrative Physiology Interdepartmental Program, University of California, Los Angeles, Los Angeles, California, United States., Butler PC; Larry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States.

Publikováno v: Physiological genomics [Physiol Genomics] 2024 Sep 01; Vol. 56 (9), pp. 621-633. Date of Electronic Publication: 2024 Jul 01.

Application of fluorescence lifetime imaging microscopy to monitor glucose metabolism in pancreatic islets in vivo .

Autor: Wang Z; Larry L. Hillblom Islet Research Center, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA 90095, USA., Archang M; Larry L. Hillblom Islet Research Center, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA 90095, USA., Gurlo T; Larry L. Hillblom Islet Research Center, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA 90095, USA., Wong E; Larry L. Hillblom Islet Research Center, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA 90095, USA., Fraser SE; Department of Biological Sciences, Bridge Institute, David Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA 90089, USA., Butler PC; Larry L. Hillblom Islet Research Center, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA 90095, USA.

Publikováno v: Biomedical optics express [Biomed Opt Express] 2023 Jul 19; Vol. 14 (8), pp. 4170-4178. Date of Electronic Publication: 2023 Jul 19 (Print Publication: 2023).

In the Setting of Beta Cell Stress, the Pancreatic Duct Gland Transcriptome Shows Characteristics of an Activated Regenerative Response

Autor: Butler, AE, Kirakossian, D, Gurlo, T, Gao, F, Coppola, G, Butler, PC

Publikováno v: Butler, AE; Kirakossian, D; Gurlo, T; Gao, F; Coppola, G; & Butler, PC. (2018). In the Setting of Beta Cell Stress, the Pancreatic Duct Gland Transcriptome Shows Characteristics of an Activated Regenerative Response.. American journal of physiology. Gastrointestinal and liver physiology. doi: 10.1152/ajpgi.00177.2018. UCLA: Retrieved from: http://www.escholarship.org/uc/item/87z0m3pr

The pancreatic duct gland (PDG) compartment has been proposed as a potential stem cell niche based on its coiled tubular structure embedded in mesenchyme, its proliferation and expansion in response to pancreatic injury, and the fact that it contains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::e53de6e7a5a87651edf1462de86f5d77
http://www.escholarship.org/uc/item/87z0m3pr

Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions.

Autor: Rivera, J. F.¹, Gurlo, T.¹, Daval, M.¹, Huang, C. J.¹, Matveyenko, A. V.¹, Butler, P. C.¹, Costes, S.¹ scostes@mednet.ucla.edu

Publikováno v: Cell Death & Differentiation. Mar2011, Vol. 18 Issue 3, p415-426. 12p. 8 Graphs.

IAPP-induced beta cell stress recapitulates the islet transcriptome in type 2 diabetes.

Autor: Blencowe M; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.; Molecular, Cellular, and Integrative Physiology Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, USA., Furterer A; Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA.; Larry L. Hillblom Islet Research Center, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA., Wang Q; Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA., Gao F; Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA., Rosenberger M; Larry L. Hillblom Islet Research Center, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA., Pei L; Larry L. Hillblom Islet Research Center, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA., Nomoto H; Larry L. Hillblom Islet Research Center, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA., Mawla AM; Department of Neurobiology, Physiology and Behavior, College of Biological Sciences, University of California, Davis, Davis, CA, USA., Huising MO; Department of Neurobiology, Physiology and Behavior, College of Biological Sciences, University of California, Davis, Davis, CA, USA., Coppola G; Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA.; Department of Neurology, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA., Yang X; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.; Molecular, Cellular, and Integrative Physiology Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, USA., Butler PC; Larry L. Hillblom Islet Research Center, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA., Gurlo T; Larry L. Hillblom Islet Research Center, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA. tgurlo@mednet.ucla.edu.

Publikováno v: Diabetologia [Diabetologia] 2022 Jan; Vol. 65 (1), pp. 173-187. Date of Electronic Publication: 2021 Sep 23.