Pharmacokinetics and distribution of 2-hydroxypropyl-β-cyclodextrin following a single intrathecal dose to cats.

Autor: Kao ML; Janssen Research & Development, LLC, Raritan, New Jersey., Stellar S; Janssen Research & Development, LLC, Raritan, New Jersey., Solon E; Madrigal Pharmaceuticals, West Conshohocken, Pennsylvania., Lordi A; XenoBiotic Laboratories, Inc, Plainsboro, New Jersey., Kasica N; Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Swain G; Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Bagel JH; Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Gurda BL; Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Vite CH; Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Publikováno v: Journal of inherited metabolic disease [J Inherit Metab Dis] 2020 May; Vol. 43 (3), pp. 618-634. Date of Electronic Publication: 2019 Dec 15.

In Situ Hybridization for Detection of AAV-Mediated Gene Expression.

Autor: Hunter JE; Research Institute of the Children's Hospital of Philadelphia, Philadelphia, PA, USA., Gurda BL; Research Institute of the Children's Hospital of Philadelphia, Philadelphia, PA, USA., Yoon SY; Research Institute of the Children's Hospital of Philadelphia, Philadelphia, PA, USA.; W.F. Goodman Center for Comparative Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA., Castle MJ; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA., Wolfe JH; Research Institute of the Children's Hospital of Philadelphia, Philadelphia, PA, USA. jhwolfe@vet.upenn.edu.; W.F. Goodman Center for Comparative Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA. jhwolfe@vet.upenn.edu.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. jhwolfe@vet.upenn.edu.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2019; Vol. 1950, pp. 107-122.

Wnt10b and Dkk-1 gene therapy differentially influenced trabecular bone architecture, soft tissue integrity, and osteophytosis in a skeletally mature rat model of osteoarthritis.

Autor: Mason JB; a Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine , University of Pennsylvania , Philadelphia , PA , USA.; b Department of Animal, Dairy and Veterinary Sciences, Center for Integrated BioSystems, School of Veterinary Medicine , Utah State University , Logan , UT , USA., Gurda BL; c Gene Therapy Program, School of Medicine , University of Pennsylvania , Philadelphia , PA , USA., Hankenson KD; a Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine , University of Pennsylvania , Philadelphia , PA , USA., Harper LR; d Department of Veterinary Population Medicine, College of Veterinary Medicine , University of Minnesota , St. Paul , MN , USA., Carlson CS; d Department of Veterinary Population Medicine, College of Veterinary Medicine , University of Minnesota , St. Paul , MN , USA., Wilson JM; c Gene Therapy Program, School of Medicine , University of Pennsylvania , Philadelphia , PA , USA., Richardson DW; a Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine , University of Pennsylvania , Philadelphia , PA , USA.

Publikováno v: Connective tissue research [Connect Tissue Res] 2017 Nov; Vol. 58 (6), pp. 542-552. Date of Electronic Publication: 2016 Dec 09.

Delivery and evaluation of recombinant adeno-associated viral vectors in the equine distal extremity for the treatment of laminitis.

Autor: Mason JB; Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, USA., Gurda BL; Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA., Van Wettere A; Utah Veterinary Diagnostic Laboratory, School of Veterinary Medicine, Utah State University, Logan, USA., Engiles JB; Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, USA., Wilson JM; Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA., Richardson DW; Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, USA.

Publikováno v: Equine veterinary journal [Equine Vet J] 2017 Jan; Vol. 49 (1), pp. 79-86. Date of Electronic Publication: 2016 Jan 16.

Neonatal Systemic AAV Induces Tolerance to CNS Gene Therapy in MPS I Dogs and Nonhuman Primates.

Autor: Hinderer C; Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Bell P; Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Louboutin JP; Section of Anatomy, Department of Basic Medical Sciences, University of West Indies, Kingston, Jamaica., Zhu Y; Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Yu H; Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Lin G; Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Choa R; Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Gurda BL; Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA; Current address: School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Bagel J; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., O'Donnell P; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Sikora T; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Ruane T; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Wang P; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Tarantal AF; Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases, California National Primate Research Center, School of Medicine, University of California, Davis, California, USA; Department of Pediatrics, School of Medicine, University of California, Davis, California, USA; Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, California, USA., Casal ML; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Haskins ME; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Wilson JM; Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. Electronic address: wilsonjm@mail.med.upenn.edu.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2015 Aug; Vol. 23 (8), pp. 1298-1307. Date of Electronic Publication: 2015 May 29.