Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Guranda Chitadze"'
Autor:
Miriam Kelm, Franziska Darzentas, Nikos Darzentas, Michaela Kotrova, Wiebke Wessels, Sonja Bendig, Claudia D. Baldus, Marcus Lettau, Nicola Gökbuget, Dieter Kabelitz, Monika Brüggemann, Guranda Chitadze
Publikováno v:
HemaSphere, Vol 7, Iss 9, p e948 (2023)
Externí odkaz:
https://doaj.org/article/521747568a5d4e879b2f590e55e36e39
Signal strength of STING activation determines cytokine plasticity and cell death in human monocytes
Autor:
Dieter Kabelitz, Michal Zarobkiewicz, Michelle Heib, Ruben Serrano, Monika Kunz, Guranda Chitadze, Dieter Adam, Christian Peters
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract The cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway is a cytosolic sensor of microbial and host-derived DNA and plays a key role in innate immunity. Activation of STING by cyclic dinucleotide (CDN) ligands in hu
Externí odkaz:
https://doaj.org/article/3035c3c9a9fd416a90405d012622c74c
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 2, p e1008702 (2021)
Intratumour heterogeneity is increasingly recognized as a frequent problem for cancer treatment as it allows for the evolution of resistance against treatment. While cancer genotyping becomes more and more established and allows to determine the gene
Externí odkaz:
https://doaj.org/article/4a7d6e99a78d423f96f8def272f6298b
Autor:
Jaydeep Bhat, Samuel Dubin, Alexandra Dananberg, Elgar Susanne Quabius, Juergen Fritsch, C. Marie Dowds, Ankit Saxena, Guranda Chitadze, Marcus Lettau, Dieter Kabelitz
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The functional plasticity and anti-tumor potential of human γδ T cells have been widely studied. However, the epigenetic regulation of γδ T-cell/tumor cell interactions has been poorly investigated. In the present study, we show that treatment wi
Externí odkaz:
https://doaj.org/article/68e6aa2d09404ae286c0bba6866dc74d
Autor:
Guranda Chitadze, Charlotte Flüh, Elgar Susanne Quabius, Sandra Freitag-Wolf, Christian Peters, Marcus Lettau, Jaydeep Bhat, Daniela Wesch, Hans-Heinrich Oberg, Stefanie Luecke, Ottmar Janssen, Michael Synowitz, Janka Held-Feindt, Dieter Kabelitz
Publikováno v:
OncoImmunology, Vol 6, Iss 11 (2017)
Despite aggressive treatment regimens based on surgery and radiochemotherapy, the prognosis of patients with grade IV glioblastoma multiforme (GBM) remains extremely poor, calling for alternative options such as immunotherapy. Immunological mechanism
Externí odkaz:
https://doaj.org/article/2b83e49bb3d54e9099b1ad92a449de09
Autor:
Guranda Chitadze, Anna Stengel, Cathrin John-Klaua, Julien Bruckmüller, Heiko Trautmann, Michaela Kotrova, Franziska Darzentas, Miriam Kelm, Karol Pal, Nikos Darzentas, Lorenz Bastian, Britta Kehden, Wiebke Wessels, Aeint-Steffen Ströh, Hans-Heinrich Oberg, Philipp M. Altrock, Constance Baer, Manja Meggendorfer, Nicola Gökbuget, Claudia D. Baldus, Claudia Haferlach, Monika Brüggemann
Publikováno v:
Blood
Autor:
Dieter Kabelitz, Guranda Chitadze
Publikováno v:
Scandinavian Journal of Immunology. 96
Glioblastoma, formerly known as glioblastoma multiforme (GBM), is the most frequent and most aggressive brain tumour in adults. The brain is an immunopriviledged organ, and the blood-brain barrier shields the brain from immune surveillance. In this r
Autor:
Christian Peters, Charlotte Flüh, Janka Held-Feindt, Elgar Susanne Quabius, Michael Synowitz, Marcus Lettau, Dieter Kabelitz, Stefanie Luecke, Guranda Chitadze
Publikováno v:
Cytometry Part B: Clinical Cytometry. 102:228-238
Background The activating Natural killer group 2 member D (NKG2D) receptor is typically expressed on NK cells, CD8 T lymphocytes, γδ T cells and small subsets of CD4 T lymphocytes. During the course of an extensive flow cytometry phenotyping of imm
Autor:
Frederik Johannsen, Guranda Chitadze
Publikováno v:
InFo Hämatologie + Onkologie. 25:28-29
Autor:
Claudia Schwinghammer, Johannes Koopmann, Guranda Chitadze, Leonid Karawajew, Monika Brüggemann, Cornelia Eckert
Publikováno v:
The Journal of molecular diagnostics : JMD. 24(8)
Real-time quantitative PCR (qPCR) using immunoglobulin/T-cell receptor gene rearrangements has been used as the gold standard for minimal residual disease (MRD) monitoring in acute lymphoblastic leukemia (ALL) for20 years. Recently, new PCR-based tec