Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Guran Yu"'
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 24, Iss 1, Pp 1-23 (2024)
Abstract Context Bu-shen-yi-jing-fang (BSYJF) has been reported to reduce amyloid-β (Aβ)1–42 deposition in the brain of APP/PS1 mice and ameliorate cognitive function. However, its neuroprotective mechanism remains unclear. Objective This study a
Externí odkaz:
https://doaj.org/article/755351e509bb48328235968722574240
Publikováno v:
Journal of Zhejiang University (Medical Sciences). 50:553-560
Publikováno v:
Zhejiang Da Xue Xue Bao Yi Xue Ban
OBJECTIVE: To investigate the effects of Radix Rehmanniae on behavior and blood brain barrier (BBB) in Alzheimer’s disease mice. METHODS: Thirty-eight 4-month-old APP/PS1 double transgenic mice were randomly divided into three groups: model group,
Publikováno v:
European Journal of Pharmacology. 834:295-304
Amyloid-β peptide (Aβ) plays a causal role in the development and progression of Alzheimer's disease (AD). Oxidative stress and activation of mitogen-activated protein kinase (MAPK) are involved in Aβ-induced neurotoxicity. Morroniside, one active
Publikováno v:
Phytotherapy Research. 32:1047-1055
Excessive amyloid beta (Aβ) deposition in brain is mainly responsible for cell damage and blood-brain barrier (BBB) disruption in Alzheimer's disease (AD). Catalpol, an iridoid glucoside extracted from the root of Rehmannia glutinosa Libosch, has ne
Publikováno v:
Neural Regeneration Research
Mounting evidence indicates that amyloid β protein (Aβ) exerts neurotoxicity by disrupting the blood-brain barrier (BBB) in Alzheimer's disease. Hyperoside has neuroprotective effects both in vitro and in vivo against Aβ. Our previous study found
Publikováno v:
Chemico-Biological Interactions. 348:109653
Angiotensin II, the effector peptide of the renin-angiotensin system, is not only a pivotal peptide implicated in the regulation of blood pressure but also a key mediator of the inflammatory processes that play an important role in the pathology of h
Publikováno v:
European journal of pharmacology. 834
Amyloid-β peptide (Aβ) plays a causal role in the development and progression of Alzheimer's disease (AD). Oxidative stress and activation of mitogen-activated protein kinase (MAPK) are involved in Aβ-induced neurotoxicity. Morroniside, one active
Publikováno v:
Phytotherapy research : PTR. 32(6)
Excessive amyloid beta (Aβ) deposition in brain is mainly responsible for cell damage and blood-brain barrier (BBB) disruption in Alzheimer's disease (AD). Catalpol, an iridoid glucoside extracted from the root of Rehmannia glutinosa Libosch, has ne
Publikováno v:
Psychogeriatrics. 12:215-225
Background: Both in vitro and in vivo, overexpression of the sortilin-related VPS10 domain containing receptor 1 (SORCS1) protein lowers amyloid-β generation. Recent studies have shown that SORCS1 variations in intron 1 are associated with sporadic